{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:50:31Z","timestamp":1792605031892,"version":"4.5.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The optic nerve sheath diameter (ONSD)\/eyeball transverse diameter (ETD) ratio has been suggested in the evaluation of intracranial pressure (ICP). The aim of this study was to evaluate the predictive value of ONSD and ONSD\/ETD in relation to risk for secondary malignant middle cerebral artery infarction (MMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 91 patients with MCA occlusion were included in this study. Data were divided into two groups based on development of MMI or not. ONSD and ETD were measured by unenhanced computed tomography (CT). The differences in ONSD and the ONSD\/ETD ratios between the MMI and non-MMI groups were compared. Receiver operating characteristic curve analyses were used to test the diagnostic value of ONSD and ONSD\/ETD independently, to predict MMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ONSD in the MMI group and non-MMI group were 5.744 \u00b1 0.140 mm and 5.443 \u00b1 0.315 mm, respectively (<jats:italic>P<\/jats:italic> = 0.001). In addition, the ONSD\/ETD ratios in the MMI group and non-MMI group were 0.258 \u00b1 0.008 and 0.245 \u00b1 0.006, respectively (<jats:italic>P<\/jats:italic> = 0.001). The receiver operating characteristic (ROC) curve demonstrated an area under the curve (AUC) for ONSD of 0.812 [95% confidence interval (CI): 0.718\u20130.906, <jats:italic>P<\/jats:italic> = 0.001], with a sensitivity of 97.4% and a specificity of 66.0% at the cut-off value of 5.520 mm. The AUC for ONSD\/ETD ratio in predicting occurrence of MMI was 0.895 (95% CI: 0.823\u20130.968, <jats:italic>P<\/jats:italic> = 0.001), with a sensitivity of 84.2% and a specificity of 92.5% at a cut-off value of 0.250.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In acute stroke patients with massive cerebral infarction, an increased ONSD or ONSD\/ETD ratio increases the odds of malignant progression and may be used as an indicator for emergent therapeutic interventions. In addition, the ONSD\/ETD ratio may be more valuable than ONSD in predicting the malignant progression of acute stroke patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2022.998389","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T09:07:57Z","timestamp":1662628077000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Optic nerve sheath diameter and optic nerve sheath diameter\/eyeball transverse diameter ratio in prediction of malignant progression in ischemic stroke"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxiong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daofeng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S1474-4422(09)70224-8","article-title":"Malignant middle cerebral artery infarction: clinical characteristics, treatment strategies, and future perspectives","volume":"8","author":"Huttner","year":"2009","journal-title":"Lancet Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1017\/S0317167100009471","article-title":"Repeated hemicraniectomy for malignant cerebral edema: getting it right first time","volume":"35","author":"Manawadu","year":"2008","journal-title":"Can J Neurol Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1474-4422(07)70036-4","article-title":"Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials","volume":"6","author":"Vahedi","year":"2007","journal-title":"Lancet Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1001\/archneur.1996.00550040037012","article-title":"'Malignant' middle cerebral artery territory infarction: clinical course and prognostic signs","volume":"53","author":"Hacke","year":"1996","journal-title":"Arch Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s001340050625","article-title":"Mortality of space-occupying ('malignant') middle cerebral artery infarction under conservative intensive care","volume":"24","author":"Berrouschot","year":"1998","journal-title":"Intensive Care Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1212\/WNL.45.7.1286","article-title":"Large hemispheric infarction, deterioration, and intracranial pressure","volume":"45","author":"Frank","year":"1995","journal-title":"Neurology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF01627611","article-title":"The subarachnoid space surrounding the optic nerves. 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