{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:06:21Z","timestamp":1777957581993,"version":"3.51.4"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have explored the application of non-invasive biomarkers of language dysfunction for the early detection of Alzheimer's disease (AD). However, language dysfunction over time may be quite heterogeneous within different diagnostic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patient demographics and clinical data were retrieved from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database for the participants without dementia who had measures of cerebrospinal fluid (CSF) biomarkers and language dysfunction. We analyzed the effect of longitudinal neuropathological and clinical correlates in the pathological process of semantic fluency and confrontation naming. The mediation effects of AD biomarkers were also explored by the mediation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>There were 272 subjects without dementia included in this analysis. Higher rates of decline in semantic fluency and confrontation naming were associated with a higher risk of progression to MCI or AD, and a greater decline in cognitive abilities. Moreover, the rate of change in semantic fluency was significantly associated with A\u03b2 deposition, while confrontation naming was significantly associated with both amyloidosis and tau burden. Mediation analyses revealed that both confrontation naming and semantic fluency were partially mediated by the A\u03b2 aggregation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the changes in language dysfunction may partly stem from the A\u03b2 deposition, while confrontation naming can also partly originate from the increase in tau burden. Therefore, this study sheds light on how language dysfunction is partly constitutive of mild cognitive impairment and dementia and therefore is an important clinical predictor.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1051382","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:46:18Z","timestamp":1684302378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Language dysfunction correlates with cognitive impairments in older adults without dementia mediated by amyloid pathology"],"prefix":"10.3389","volume":"14","author":[{"given":"Chunchen","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jalz.2017.12.006","article-title":"The cost of Alzheimer's disease in China and re-estimation of costs worldwide","volume":"14","author":"Jia","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S1474-4422(19)30290-X","article-title":"Dementia in China: epidemiology, clinical management, and research advances","volume":"19","author":"Jia","year":"2020","journal-title":"Lancet Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"l6217","DOI":"10.1136\/bmj.l6217","article-title":"Cognitive symptoms of Alzheimer's disease: clinical management and prevention","volume":"367","author":"Joe","year":"2019","journal-title":"BMJ."},{"key":"B4","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/ijnp\/pyx012","article-title":"Discontinuation, efficacy, and safety of cholinesterase inhibitors for Alzheimer's disease: a meta-analysis and meta-regression of 43 randomized clinical trials enrolling 16,106 patients","volume":"20","author":"Blanco-Silvente","year":"2017","journal-title":"Int J Neuropsychopharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/s41582-018-0070-3","article-title":"Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease","volume":"14","author":"Kivipelto","year":"2018","journal-title":"Nat Rev Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13195-017-0297-z","article-title":"Alzheimer's disease prevention: from risk factors to early intervention","volume":"9","author":"Crous-Bou","year":"2017","journal-title":"Alzheimers Res Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41582-021-00520-w","article-title":"Jr, Vergallo A. 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