{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:11Z","timestamp":1753891571448,"version":"3.41.2"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gait is one of the activities most affected by the symptoms of Parkinson\u2019s disease and may show a linear decline as the disease progresses. Early assessment of its performance through clinically relevant tests is a key factor in designing efficient therapeutic plans and procedures, which can be enhanced using simple and low-cost technological instruments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effectiveness of a two-dimensional gait assessment to identify the decline in gait performance associated with Parkinson\u2019s disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and seventeen people with Parkinson\u2019s disease, classified between early and intermediate stages, performed three clinical gait tests (Timed Up and Go, Dynamic Gait Index, and item 29 of the Unified Parkinson\u2019s Disease Rating Scale), in addition to a six-meter gait test recorded by a two-dimensional movement analysis software. Based on variables generated by the software, a gait performance index was created, allowing a comparison between its results with the results obtained by clinical tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were differences between sociodemographic variables directly related to the evolution of Parkinson\u2019s disease. Compared to clinical tests, the index proposed to analyze gait showed greater sensitivity and was able to differentiate the first three stages of disease evolution (Hoehn and Yahr I and II: <jats:italic>p<\/jats:italic>\u2009=\u20090.03; Hoehn and Yahr I and III: <jats:italic>p<\/jats:italic>\u2009=\u20090.00001; Hoehn and Yahr II and III: <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the index provided by a two-dimensional movement analysis software that uses kinematic gait variables, it was possible to differentiate the gait performance decline among the three first stages of Parkinson\u2019s disease evolution. This study offers a promising possibility of early identification of subtle changes in an essential function of people with Parkinson\u2019s disease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1101650","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T09:17:06Z","timestamp":1681895826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["A non-expensive bidimensional assessment can detect subtle alterations in gait performance in people in the early stages of Parkinson\u2019s disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Matheus Silva","family":"d'Alencar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Venas","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Fraz\u00e3o","family":"Helene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos","family":"Roque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Garcia Vivas","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elisa Pimentel","family":"Piemonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/mds.24973","article-title":"Motor signs in the prodromal phase of Parkinson's disease","volume":"27","author":"Maetzler","year":"2012","journal-title":"Mov Disord"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S1474-4422(19)30044-4","article-title":"Gait impairments in Parkinson's disease","volume":"18","author":"Mirelman","year":"2019","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S1474-4422(11)70143-0","article-title":"Freezing of gait: moving forward on a mysterious clinical phenomenon","volume":"10","author":"Nutt","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.parkreldis.2016.02.006","article-title":"Identifying clinical measures that most accurately reflect the progression of disability in Parkinson disease","volume":"25","author":"Ellis","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000488780","article-title":"Estimating the evolution of disease in the Parkinson's progression markers initiative","volume":"18","author":"Iddi","year":"2018","journal-title":"Neurodegener Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1212\/01.wnl.0000183359.50822.f2","article-title":"Progression of motor impairment and disability in Parkinson disease: a population-based study","volume":"65","author":"Alves","year":"2005","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2340\/16501977-2254","article-title":"Assessing timed up and go in Parkinson's disease: reliability and validity of timed up and go assessment of biomechanical strategies","volume":"49","author":"da Silva","year":"2017","journal-title":"J Rehabil Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/mds.26572","article-title":"Movement disorders society rating scales committee. 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