{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:26:38Z","timestamp":1788848798344,"version":"build-2803163510"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare different MRI diagnostic criteria for endolymphatic hydrops (EH) and to investigate the relation between audiovestibular and MRI findings in Meniere's disease (MD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Prospective cross-sectional cohort study in 2 referral centers included 76 patients with unilateral (<jats:italic>n<\/jats:italic> = 62) or bilateral (<jats:italic>n<\/jats:italic> = 14) MD. All patients underwent inner ear 3T-MRI 4 h (<jats:italic>n<\/jats:italic> = 52) or &amp;gt;24H (<jats:italic>n<\/jats:italic> = 24) following audiovestibular tests. T2-CISS and 3D-FLAIR images 4H after gadolinium were obtained. EH diagnosis was based on saccular morphology on coronal views (T2 and 3D-FLAIR), semi quantitative estimation of endolymphatic space enlargement, and saccule utricle ratio inversion (SURI) on 3D-FLAIR axial views.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SURI was the best criterion related to the disease side (43 SURI+ on symptomatic ears, <jats:italic>n<\/jats:italic> = 77, <jats:italic>vs<\/jats:italic>. 6 SURI+ on asymptomatic ears, <jats:italic>n<\/jats:italic> = 53, <jats:italic>p<\/jats:italic> &amp;lt; 0.0001, Chi-2). Same-day MRI revealed relation between EH, hearing loss and caloric weakness which could not be detected on delayed MRI: SURI was associated with a higher pure-tone average (43 \u00b1 4.1 dB in SURI+ ears, <jats:italic>n<\/jats:italic> = 42 <jats:italic>vs<\/jats:italic>. 23 \u00b1 2.6 SURI-, <jats:italic>n<\/jats:italic> = 62, <jats:italic>p<\/jats:italic> &amp;lt; 0.0001, unpaired t-test,), and a higher proportion of vestibular caloric weakness (23\/46 SURI+ ears <jats:italic>vs<\/jats:italic>. 4\/62 SURI-, <jats:italic>p<\/jats:italic> &amp;lt; 0.001, Chi-2). Among all criteria, SURI combined to caloric weakness was the best predictor of the affected side in a logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SURI had the strongest relation to the side the disease and audio vestibular findings for unilateral, probable and definite meniere disease. A short delay between MRI and audio vestibular tests improved the coherence between the findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1105461","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T05:52:05Z","timestamp":1674712325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Confrontation of endolymphatic hydrops diagnosis on 3-Tesla MRI to clinical and audiovestibular findings in Meniere's disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Sarah","family":"Diorflar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Guigou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Daguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Loup","family":"Bensimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Toupet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Bozorg-Grayeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.otorri.2015.05.005","article-title":"Classification committee of the barany society; japan society for equilibrium research; European academy of otology and neurotology (EAONO); equilibrium committee of the American academy of otolaryngology-head and neck surgery (AAO-HNS); Korean balance society. Diagnostic criteria for Meni\u00e8re's disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J Vestib Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00016489.2020.1749299","article-title":"Phonophobia and migraine features in patients with definite Meniere's disease: pentad or triad\/tetrad?","volume":"11","author":"Saberi","year":"2020","journal-title":"Acta Otolaryngol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3109\/00016488309139420","article-title":"Paroxysmal vertigo with and without cochlear symptoms","volume":"95","author":"Oosterveld","year":"1983","journal-title":"Acta Otolaryngol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meni\u00e8re's disease? A contemporary re-evaluation of endolymphatic hydrops","volume":"263","author":"G\u00fcrkov","year":"2016","journal-title":"J Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000346343","article-title":"Diagnostic usefulness of multifrequency tympanometry for M\u00e9ni\u00e8re's disease","volume":"18","author":"Sugasawa","year":"2013","journal-title":"Audiol Neurootol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1097\/MAO.0000000000000604","article-title":"Effects of body tilt on multifrequency admittance tympanometry","volume":"36","author":"Franco-Vidal","year":"2015","journal-title":"Otol Neurotol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/14992027.2019.1606947","article-title":"A systematic review and meta-analysis of extratympanic electrocochleography in M\u00e9ni\u00e8re's disease diagnosis","volume":"58","author":"Ayub","year":"2019","journal-title":"Int J Audiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3766\/jaaa.17.1.6","article-title":"Electrocochleography in the evaluation of patients with M\u00e9ni\u00e8re's disease\/endolymphatic hydrops","volume":"17","author":"Ferraro","year":"2006","journal-title":"J Am Acad Audiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1080\/000164800750045965","article-title":"Electrocochleography in the diagnosis of Meniere's disease","volume":"120","author":"Conlon","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/00016480902729827","article-title":"Grading of endolymphatic hydrops using magnetic resonance imaging","volume":"560","author":"Nakashima","year":"2009","journal-title":"Acta Otolaryngol Suppl."},{"key":"B11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s41747-017-0020-7","article-title":"Imaging of the saccule for the diagnosis of endolymphatic hydrops in Meniere disease, using a three-dimensional T2-weighted steady state free precession sequence: accurate, fast, and without contrast material intravenous injection","volume":"1","author":"Venkatasamy","year":"2017","journal-title":"Eur Radiol Exp."},{"key":"B12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00234-019-02155-7","article-title":"The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meni\u00e8re's disease on MRI","volume":"61","author":"Bernaerts","year":"2019","journal-title":"Neuroradiology."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.otc.2010.06.001","article-title":"Magnetic resonance imaging of the inner Ear in Meniere's disease","volume":"43","author":"Pyykk\u00f6","year":"2010","journal-title":"Otolaryngol Clin North Am."},{"key":"B14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/MAO.0b013e31820e7614","article-title":"Reliability of magnetic resonance imaging performed after intratympanic administration of gadolinium in the identification of endolymphatic hydrops in patients with M\u00e9ni\u00e8re's disease","volume":"32","author":"Fiorino","year":"2011","journal-title":"Otol Neurotol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00405-010-1353-5","article-title":"performed after intratympanic gadolinium administration in patients with M\u00e9ni\u00e8re's disease: correlation with symptoms and signs","volume":"268","author":"Fiorino","year":"2011","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3109\/00016489.2010.548402","article-title":"Visualization of endolymphatic hydrops after administration of a standard dose of an intravenous gadolinium-based contrast agent","volume":"131","author":"Tanigawa","year":"2011","journal-title":"Acta Otolaryngol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3174\/ajnr.A3856","article-title":"Detection and grading of endolymphatic hydrops in Meni\u00e8re disease using MR imaging","volume":"35","author":"Bar\u00e1th","year":"2014","journal-title":"AJNR Am J Neuroradiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1007\/s00330-016-4701-z","article-title":"MRI of endolymphatic hydrops in patients with Meniere's disease: a case-controlled study with a simplified classification based on saccular morphology","volume":"27","author":"Atty\u00e9","year":"2017","journal-title":"Eur Radiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"647296","DOI":"10.3389\/fneur.2021.647296","article-title":"Intravenous delayed gadolinium-enhanced MR imaging of the endolymphatic space: a methodological comparative study","volume":"12","author":"Boegle","year":"2021","journal-title":"Front Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1007\/s00330-015-3712-5","article-title":"Recurrent peripheral vestibulopathy: Is MRI useful for the diagnosis of endolymphatic hydrops in clinical practice?","volume":"25","author":"Atty\u00e9","year":"2015","journal-title":"Eur Radiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1177\/000348948909801108","article-title":"Meniere's syndrome and endolymphatic hydrops. Double-blind temporal bone study","volume":"98","author":"Rauch","year":"1989","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3233\/VES-180646","article-title":"Systematic review of magnetic resonance imaging for diagnosis of Meniere disease","volume":"29","author":"Lopez-Escamez","year":"2019","journal-title":"J Vestib Res."},{"key":"B23","first-page":"1","article-title":"Electronystagmography","volume":"189","author":"Jongkees","year":"1964","journal-title":"Acta Otolaryngol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00405-010-1345-5","article-title":"Asymmetric vestibular evoked myogenic potentials in unilateral Meni\u00e8re patients","volume":"268","author":"Kingma","year":"2011","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1055\/s-0039-3402063","article-title":"Video head impulse testing: from bench to bedside","volume":"40","author":"Chen","year":"2020","journal-title":"Semin Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neurad.2017.01.059","article-title":"Endolymphatic hydrops imaging: why oving from semi-quantitative to anatomical-based evaluation","volume":"44","author":"Eliezer","year":"2017","journal-title":"J Neuroradiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"595038","DOI":"10.3389\/fneur.2020.595038","article-title":"The correlation of a 2d volume-referencing endolymphatic-hydrops grading system with extra-tympanic electrocochleography in patients with definite M\u00e9ni\u00e8re's disease","volume":"20","author":"He","year":"2021","journal-title":"Front Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.amjoto.2004.11.005","article-title":"Electrocochleography in patients with Meniere's disease","volume":"26","author":"Kim","year":"2005","journal-title":"Am J Otolaryngol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00005537-200203000-00019","article-title":"Augmentation of vestibular evoked myogenic potentials: an indication for distended saccular hydrops","volume":"112","author":"Young","year":"2002","journal-title":"Laryngoscope."},{"key":"B30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/00016489.2016.1217042","article-title":"Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease","volume":"137","author":"Morimoto","year":"2017","journal-title":"Acta Otolaryngol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clinimag.2014.09.014","article-title":"Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere's disease: correlation of quantitative measures of endolymphatic hydrops with hearing","volume":"39","author":"Sepahdari","year":"2015","journal-title":"Clin Imaging."},{"key":"B32","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/MAO.0000000000001094","article-title":"Focal endolymphatic hydrops as seen in the pars inferior of the human inner ear","volume":"37","author":"Nadol","year":"2016","journal-title":"Otol Neurotol."},{"key":"B33","first-page":"73","article-title":"Pathogenesis of Meniere's syndrome","volume-title":"M\u00e9ni\u00e8re's Disease","author":"Nadol","year":"1999"},{"key":"B34","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00401-018-1927-7","article-title":"Loffing J, Rauch SD, Nadol JB Jr, Liberman MC, Adams JC. Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease","volume":"137","author":"O'Malley","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","article-title":"Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?","volume":"26","author":"Merchant","year":"2005","journal-title":"Otol Neurotol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fneur.2016.00182","article-title":"Clinical subgroups in bilateral meniere disease","volume":"7","author":"Frejo","year":"2016","journal-title":"Front Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/lio2.115","article-title":"Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment","volume":"2","author":"Fukushima","year":"2017","journal-title":"Laryngoscope Investig Otolaryngol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1159\/000258681","article-title":"Relationship between the degree of endolymphatic hydrops and electrocochleography","volume":"15","author":"Yamamoto","year":"2010","journal-title":"Audiol Neurootol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e001555","DOI":"10.1136\/bmjopen-2012-001555","article-title":"Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops","volume":"3","author":"Pyykk\u00f6","year":"2013","journal-title":"BMJ Open."},{"key":"B40","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/MAO.0000000000001021","article-title":"Click stimulus electrocochleography vs. mri with intratympanic contrast in M\u00e9ni\u00e8re's disease: a systematic review","volume":"37","author":"Ziylan","year":"2016","journal-title":"Otol Neurotol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1097\/MAO.0b013e31825d9a95","article-title":"In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed M\u00e9ni\u00e8re's disease","volume":"33","author":"G\u00fcrkov","year":"2012","journal-title":"Otol Neurotol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ejrad.2018.10.023","article-title":"Three-tesla magnetic resonance imaging of the vestibular endolymphatic space: a systematic qualitative description in healthy ears","volume":"109","author":"Conte","year":"2018","journal-title":"Eur J Radiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00405-018-4865-z","article-title":"A comparison of semi-automated volumetric vs linear measurement of small vestibular schwannomas","volume":"275","author":"MacKeith","year":"2018","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.clineuro.2016.04.010","article-title":"Evaluating vestibular schwannoma size and volume on magnetic resonance imaging: an interand intra-rater agreement study","volume":"145","author":"Lawson McLean","year":"2016","journal-title":"Clin Neurol Neurosurg."},{"key":"B45","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1017\/S0022215114001972","article-title":"Endolymphatic hydrops and M\u00e9ni\u00e8re's disease: a lesion meta-analysis","volume":"128","author":"Pender","year":"2014","journal-title":"J Laryngol Otol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e48932","DOI":"10.7554\/eLife.48932.056","article-title":"Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T","volume":"8","author":"Sitek","year":"2019","journal-title":"Elife."},{"key":"B47","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/MAO.0000000000001242","article-title":"Ultra-High-Field Magnetic Resonance Imaging of the Human Inner Ear at 117 Tesla","volume":"38","author":"Thylur","year":"2017","journal-title":"Otol Neurotol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1118\/1.3077125","article-title":"MRI endoscopy using intrinsically localized probes","volume":"36","author":"Sathyanarayana","year":"2009","journal-title":"Med Phys."},{"key":"B49","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/jmri.24687","article-title":"Image reconstruction: an overview for clinicians","volume":"41","author":"Hansen","year":"2015","journal-title":"J Magn Reson Imaging."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1105461\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T05:52:08Z","timestamp":1674712328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1105461\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,26]]},"references-count":49,"alternative-id":["10.3389\/fneur.2023.1105461"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1105461","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,26]]},"article-number":"1105461"}}