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High-intensity ultrasound can be used for thermal ablation by taking advantage of its high-energy characteristics. Low-intensity ultrasound, which produces low energy, can be used as a means to regulate the nervous system. The present review describes the current status of research on low-intensity transcranial ultrasound stimulation (LITUS) in the treatment of neurological disorders, such as epilepsy, essential tremor, depression, Parkinson's disease (PD), and Alzheimer's disease (AD). This review summarizes preclinical and clinical studies using LITUS to treat the aforementioned neurological disorders and discusses their underlying mechanisms.<\/jats:p>","DOI":"10.3389\/fneur.2023.1117188","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T05:20:10Z","timestamp":1678252810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic 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