{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:17:57Z","timestamp":1754558277676,"version":"3.41.2"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>We report a case of an emmetropic woman with excessive daytime sleepiness in alternation with insomnia consistent with the diagnosis criteria of a non-24 h sleep\u2013wake disorder. After being refractory to the usual non-pharmacologic and pharmacologic treatment, we detected a deficiency of vitamin B12, vitamin D3, and folic acid. Substitution of these treatments led to a return of a 24 h sleep\u2013wake rhythm though this remained independent from the external light\u2013dark cycle. The question arises whether the vitamin D deficiency could be regarded as an epiphenomenon or whether there is an up-to-date unknown connection to the inner zeitgeber.<\/jats:p>","DOI":"10.3389\/fneur.2023.1141835","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T05:27:19Z","timestamp":1681709239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin D deficiency promoting non-24 h sleep\u2013wake disorder: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Richard Friedrich","family":"Radlberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Baden","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"journal-title":"Chronobiology: Biological Timekeeping","year":"2004","author":"Dunlap","key":"B1"},{"volume-title":"The Circadian System Of Man: Results Of Experiments Under Temporal Isolation","year":"2013","author":"Wever","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.5664\/jcsm.5100","article-title":"Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). 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