{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:38:48Z","timestamp":1789141128436,"version":"build-2803163510"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIBP) were measured using a transcranial Doppler (TCD) and Finometer, followed by the calculation of cerebral hemodynamic parameters including CCP, resistance area product (RAP), pulsatility index (PI), and pulse pressure (PP). EPVS were graded separately in the basal ganglia (BG) and centrum semiovale (CSO), using a visual semiquantitative ordinal scale. Patients with EPVS &amp;gt;10 were classified into the severe BG-EPVS group and severe CSO-EPVS group, and the remainder into the mild BG-EPVS group and the mild CSO-EPVS group. Spearman\u2019s correlation and binary logistic regression analysis were performed to analyze the relationship between hemodynamic parameters and BG-EPVS and CSO-EPVS, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 107 patients were enrolled. The severe BG-EPVS group had higher CCP, mean arterial blood pressure (MABP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) than that in the mild BG-EPVS group (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.05). There was no statistical difference in hemodynamic parameters between the severe CSO-EPVS group and the mild CSO-EPVS group. Spearman\u2019s correlation analysis showed that CCP was positively associated with BG-EPVS (<jats:italic>rho<\/jats:italic> =\u20090.331, <jats:italic>p<\/jats:italic> &amp;lt;\u20090.001) and CSO-EPVS (<jats:italic>rho<\/jats:italic> =\u20090.154, <jats:italic>p<\/jats:italic> =\u20090.044). The binary logistic regression analysis showed that CCP was independently associated with severe BG-EPVS (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.05) and not with CSO-EPVS (<jats:italic>p<\/jats:italic> &amp;gt;\u20090.05) after adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CCP representing cerebrovascular tension was independently associated with BG-EPVS.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1165469","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:22:43Z","timestamp":1696512163000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiayi","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanrong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00234-021-02718-7","article-title":"Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular 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