{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:43:02Z","timestamp":1780497782720,"version":"3.54.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012990","name":"Universit\u00e0 degli Studi di Siena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to estimate the incidence of Vestibular neuritis (VN) in three different districts in Italy, its epidemiological features, and the prevalence of comorbidities associated with it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational prospective study of 198 patients referred to ENT departments in Siena, Grosseto, and Cuneo was carried out over a 2-year period. Each patient underwent a complete otoneurologic examination in the first 48 h from the onset of symptoms and a brain MRI in the early stages of the disease. The follow-up lasted for 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total VN incidence rate of the three municipalities was 48.497 (95% CI: 48.395\u201348.598) and its standardized value was 53.564 (95% CI: 53.463\u201353.666). The total VN incidence rate for the whole sample (municipality and district of the three centers) was 18.218 (95% CI: 18.164\u201318.272), and its standardized value was 20.185 (95% CI: 20.129\u201320.241). A significant difference was highlighted between patients living in the city compared to those living in the surrounding area (<jats:italic>p<\/jats:italic> &amp;lt; 0.000), this may be due to the ease of reaching the otoneurological referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The total incidence rate for the three municipalities was 48.497. This result is higher than previously reported studies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1177621","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:07:02Z","timestamp":1684390022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The incidence of vestibular neuritis in Italy"],"prefix":"10.3389","volume":"14","author":[{"given":"Marco","family":"Mandal\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Salerni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bindi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Gualtieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Corallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Viberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gusinu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Fantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ponzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Astore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Boccuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Nuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.ncl.2015.04.012","article-title":"Acute unilateral vestibulopathy","volume":"33","author":"Strupp","year":"2015","journal-title":"Neurol Clin"},{"key":"B2","first-page":"67","article-title":"The epidemiology of dizziness and vertigo","volume-title":"Handbook of Clinical Neurology","author":"Neuhauser","year":"2016"},{"key":"B3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/00016480310002122","article-title":"Clinical and epidemiological study of vertigo at an outpatient clinic","volume":"124","author":"Guilemany","year":"2004","journal-title":"Acta Otolaryngol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10072-014-1912-4","article-title":"Incidence, seasonality and comorbidity in vestibular neuritis","volume":"36","author":"Adamec","year":"2015","journal-title":"Neurol Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1055\/s-0029-1241040","article-title":"Vestibular neurites","volume":"29","author":"Strupp","year":"2009","journal-title":"Semin Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3109\/00016489309128061","article-title":"Vestibular neuronitis: Epidemiological survey by questionnaire in Japan","volume":"503","author":"Sekitani","year":"1993","journal-title":"Acta Otolaryngol Suppl"},{"key":"B7","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1212\/WNL.56.4.436","article-title":"The interrelations of migraine, vertigo, and migrainous vertigo","volume":"56","author":"Neuhauser","year":"2001","journal-title":"Neurology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1212\/01.wnl.0000244473.84246.76","article-title":"Low recurrence rate of vestibular neuritis: A long-term follow-up","volume":"67","author":"Huppert","year":"2006","journal-title":"Neurology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3109\/00016489.2011.593551","article-title":"Recurrence of vertigo in patients with vestibular neuritis","volume":"131","author":"Kim","year":"2011","journal-title":"Acta Otolaryngol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3109\/00016480903311278","article-title":"Vestibular neuritis: Recurrence and incidence of secondary benign paroxysmal positional vertigo","volume":"130","author":"Mandal\u00e0","year":"2010","journal-title":"Acta Otolaryngol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/WCO.0000000000000652","article-title":"Long-term clinical outcome in vestibular neuritis","volume":"32","author":"Bronstein","year":"2019","journal-title":"Curr Opin Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/archoto.2007.35","article-title":"Effectiveness of careful bedside examination in assessment, diagnosis, and prognosis of vestibular neuritis","volume":"134","author":"Mandal\u00e0","year":"2008","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1212\/WNL.0b013e3181a55ecf","article-title":"Bucket of static vestibular function","volume":"72","author":"Zwergal","year":"2009","journal-title":"Neurology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.anl.2016.07.020","article-title":"Vestibular neuritis: Involvement and long-term recovery of individual semicircular canals","volume":"44","author":"B\u00fcki","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1212\/WNL.0000000000003223","article-title":"Vestibular neuritis affects both superior and inferior vestibular nerves","volume":"87","author":"Taylor","year":"2016","journal-title":"Neurology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1007\/s00415-011-6375-4","article-title":"Inferior vestibular neuritis","volume":"259","author":"Kim","year":"2012","journal-title":"J Neurol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1097\/MAO.0000000000002226","article-title":"Clinical characteristics of acute vestibular neuritis according to involvement site","volume":"40","author":"Lee","year":"2019","journal-title":"Otol Neurotol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3233\/VES-220201","article-title":"Acute unilateral vestibulopathy\/vestibular neuritis: Diagnostic criteria","volume":"32","author":"Strupp","year":"2022","journal-title":"J Vestib Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The international classification of headache disorders, 3rd edition (beta version)","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"key":"B20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1177\/0333102413487610","article-title":"ICHD-3 beta is published. Use it immediately","volume":"33","author":"Olesen","year":"2013","journal-title":"Cephalalgia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/jhh.2016.71","article-title":"Prevalence and control of hypertension in the general practice in Italy: Updated analysis of a large database","volume":"31","author":"Tocci","year":"2017","journal-title":"J Hum Hypertens."},{"key":"B22","unstructured":"2017"},{"key":"B23","unstructured":"Roma: Istituto superiore di sanit\u00e02002"},{"key":"B24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10194-012-0437-6","article-title":"Italian guidelines for primary headaches: 2012 revised version","volume":"13","author":"Sarchielli","year":"2012","journal-title":"J Headache Pain."},{"key":"B25","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1136\/jnnp.2006.100420","article-title":"Epidemiology of benign paroxysmal positional vertigo: A population based study","volume":"2007","author":"von Brevern","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B26","first-page":"47","article-title":"Incidence and prevalence of Meni\u00e8re's disease in Tuscany","volume-title":"Meni\u00e8re's Disease: Perspectives in the \u201890s. Proceedings of the 3rd International Symposium on Meni\u00e8re's Disease","author":"Nuti","year":"1993"},{"key":"B27","first-page":"198","article-title":"Epidemiology of Bell's palsy in an Italian Health District: Incidence and case-control study","volume":"30","author":"Monini","year":"2010","journal-title":"Acta Otorhinolaryngol Ital."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1177621\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:07:09Z","timestamp":1684390029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1177621\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":27,"alternative-id":["10.3389\/fneur.2023.1177621"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1177621","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"article-number":"1177621"}}