{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:15:19Z","timestamp":1793085319310,"version":"4.5.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Odors evoking vivid and intensely felt autobiographical memories are known as the \u201cProust phenomenon,\u201d delineating the particularity of olfaction in being more effective with eliciting emotional memories than other sensory modalities. The phenomenon has been described extensively in healthy participants as well as in patients during pre-epilepsy surgery evaluation after focal stimulation of the amygdalae and post-traumatic stress disorder (PTSD). In this study, we provide the inaugural description of aversive odor-evoked autobiographical memories after stroke in the right hippocampal, parahippocampal, and thalamic nuclei. As potential underlying neural signatures of the phenomenon, we discuss the disinhibition of limbic circuits and impaired communication between the major networks, such as saliency, central executive, and default mode network.<\/jats:p>","DOI":"10.3389\/fneur.2023.1183265","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T02:11:18Z","timestamp":1689300678000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: \u201cProust phenomenon\u201d after right posterior cerebral artery occlusion"],"prefix":"10.3389","volume":"14","author":[{"given":"Sophie","family":"De Beukelaer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Sokolov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"M\u00fcri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3758\/BF03210754","article-title":"Odor memory: review and analysis","volume":"3","author":"Herz","year":"1996","journal-title":"Psychon Bull Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.expneurol.2016.08.001","article-title":"Odor-induced recall of emotional memories in PTSD-Review and new paradigm for research","volume":"284","author":"Daniels","year":"2022","journal-title":"Exp Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4088\/JCP.v64n0214","article-title":"Olfaction as a traumatic reminder in posttraumatic stress disorder: case reports and review","volume":"64","author":"Vermetten","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"B4","first-page":"126","article-title":"What can you do with your nose?","volume":"41","author":"Laird","year":"1935","journal-title":"Sci. Month. New York."},{"key":"B5","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/chemse\/20.5.517","article-title":"The emotional distinctiveness of odor-evoked memories","volume":"20","author":"Herz","year":"1995","journal-title":"Chem Senses."},{"key":"B6","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/j.1749-6632.1998.tb10643.x","article-title":"Are odors the best cues to memory? A cross-modal comparison of associative memory stimuli","volume":"855","author":"Herz","year":"1998","journal-title":"Ann N Y Acad Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"13984","DOI":"10.1073\/pnas.1404991111","article-title":"Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons","volume":"111","author":"Lepousez","year":"2014","journal-title":"Proc Nat Acad Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.nicl.2017.09.018","article-title":"Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD","volume":"17","author":"Cortese","year":"2018","journal-title":"NeuroImage Clin"},{"key":"B9","unstructured":""},{"key":"B10","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1212\/01.WNL.0000137037.56916.3F","article-title":"Cortical stimulation study of the role of Rhinal cortex in d\u00e9j\u00e0 vu and reminiscence of memories","volume":"63","author":"Bartolomei","year":"2004","journal-title":"Neurology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.brainresrev.2009.09.007","article-title":"The functional role of the medio dorsal thalamic nucleus in olfaction","volume":"62","author":"Tham","year":"2009","journal-title":"Brain Res Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/epi.13791","article-title":"Defining epileptogenic networks: contribution of SEEG and signal analysis","volume":"58","author":"Bartolomei","year":"2017","journal-title":"Epilepsia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1093\/cercor\/bhl041","article-title":"Emotion induction after direct intracerebral stimulations of human amygdala","volume":"17","author":"Lanteaume","year":"2007","journal-title":"Cereb Cortex."},{"key":"B14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/02699931.2011.555475","article-title":"Proust revisited: odours triggers of aversive memories","volume":"26","author":"Toffolo","year":"2012","journal-title":"ACogn Emot."},{"key":"B15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2014now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat Rev Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"20868","DOI":"10.1073\/pnas.2007141117","article-title":"Brain circuits signaling the absence of emotion in body language","volume":"117","author":"Sokolov","year":"2020","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/17437199.2019.1700819","article-title":"The association between worry and rumination with sleep in non clinical populations: a systematic review and meta-analysis","volume":"14","author":"Clancy","year":"2020","journal-title":"Health Psychol Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/j.jpsychires.2015.08.015","article-title":"Burning odor-elicited anxiety in OEF\/OIF combat veterans: inverse relationship to gray matter volume in olfactory cortex","volume":"70","author":"Cortese","year":"2015","journal-title":"J Psychiatric Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/psyp.12039","article-title":"What the heart forgets: Cardiac timing influences memory for words and is modulated by metacognition and interoceptive sensitivity","volume":"50","author":"Garfinkel","year":"2013","journal-title":"Psychophysiology."},{"key":"B20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1162\/jocn_a_00313","article-title":"Spatial cognition and the hippocampus: the Anterior\u2013posterior axis","volume":"25","author":"Nadel","year":"2013","journal-title":"J Cog Neurosci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1016\/j.neuropsychologia.2010.07.030","article-title":"fMRI studies of successful emotional memory encoding: a quantitative meta-analysis","volume":"48","author":"Murty","year":"2010","journal-title":"Neuropsychologia."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1523\/JNEUROSCI.4640-10.2011","article-title":"Anterior hippocampus and goal-directed spatial decision making","volume":"31","author":"Viard","year":"2011","journal-title":"J Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.neuron.2011.10.014","article-title":"hippocampal marker of recollection memory ability among healthy young adults: contributions of posterior and anterior segments","volume":"72","author":"Poppenk","year":"2011","journal-title":"Neuron."},{"key":"B24","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1503\/jpn.110069","article-title":"Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder","volume":"37","author":"Sripada","year":"2012","journal-title":"J Psychiatry Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.neuroimage.2013.09.018","article-title":"A comparison of statistical methods for detecting context-modulated functional connectivity in fMRI","volume":"84","author":"Cisler","year":"2014","journal-title":"Neuroimage."},{"key":"B26","doi-asserted-by":"publisher","first-page":"164","DOI":"10.12688\/f1000research.17961.1","article-title":"Sensory-specific predictive models in the human anterior insula","volume":"8","author":"Sharvit","year":"2019","journal-title":"F1000Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1002\/hbm.22113","article-title":"Keeping the body in mind: insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness","volume":"34","author":"Simmons","year":"2013","journal-title":"Hum Brain Mapp."},{"key":"B28","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3758\/s13415-016-0447-y","article-title":"Emotion regulation and amygdala-precuneus connectivity: focusing on attentional deployment","volume":"16","author":"Ferri","year":"2016","journal-title":"Cogn Affect Behav Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11920-017-0840-4","article-title":"A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies","volume":"19","author":"Akiki","year":"2017","journal-title":"Curr Psychiatry Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nn.4613","article-title":"Dorsal hippocampus contributes to model-based planning","volume":"20","author":"Miller","year":"2017","journal-title":"Nat Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3390\/sym11091129","article-title":"Olfactory laterality is valence-dependent in mice","volume":"11","author":"Jozet-Alves","year":"2019","journal-title":"Symmetry."},{"key":"B32","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00429-010-0262-0","article-title":"Saliency, switching, attention and control: a network model of insula function","volume":"214","author":"Menon","year":"2010","journal-title":"Brain Struct Funct."},{"key":"B33","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.21201.1","article-title":"Fear conditioning and the basolateral amygdala","volume":"9","author":"Sun","year":"2020","journal-title":"F1000Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/STROKEAHA.121.035671","article-title":"Perceptual disorders after stroke: a scopping review of interventions","volume":"53","author":"Hazelton","year":"2022","journal-title":"Stroke."},{"key":"B35","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00429-018-1760-8","article-title":"Linking structural and effective brain connectivity: structurally informed parametric empirical bayes (si-PEB)","volume":"224","author":"Sokolov","year":"2019","journal-title":"Brain Struct Funct."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1111\/tops.12504","article-title":"On the nature of explanations offered by network science: a perspective from and for practicing neuroscientists","volume":"12","author":"Bertolero","year":"2020","journal-title":"Top Cogn Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nrn3492","article-title":"The contextual brain: implications for fear conditioning, extinction and psychopathology","volume":"14","author":"Maren","year":"2013","journal-title":"Nat Rev Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"E12034","DOI":"10.1073\/pnas.1812859115","article-title":"Structural and effective brain connectivity underlying biological motion detection","volume":"115","author":"Sokolov","year":"2018","journal-title":"Proc Natl Acad Sci U S A."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1183265\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T02:11:22Z","timestamp":1689300682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1183265\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":38,"alternative-id":["10.3389\/fneur.2023.1183265"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1183265","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]},"article-number":"1183265"}}