{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:20:36Z","timestamp":1785468036380,"version":"3.56.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-NS086736"],"award-info":[{"award-number":["R01-NS086736"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although essential tremor (ET) patients have greater odds of mild cognitive impairment (MCI) and dementia than age-matched controls, the functional consequences of these enhanced odds are unknown. We examined associations between cognitive diagnosis and the occurrence of near falls, falls, use of a walking aid or a home health aide, non-independent living, or hospitalizations within a prospective, longitudinal study of ET patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 131 ET patients (mean baseline age = 76.4 \u00b1 9.4 years) completed a battery of neuropsychological tests and questions about life events and were assigned diagnoses of normal cognition (NC), MCI, or dementia at the baseline and at 18-, 36-, and 54-month follow-ups. Kruskall\u2013Wallis, chi-square, and Mantel\u2013Haenszel tests assessed whether the diagnosis was associated with the occurrence of these life events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with final diagnoses of dementia were more often reported as living non-independently than NC or MCI patients and more often used walking aids than NC patients, with a <jats:italic>p-<\/jats:italic>value of &amp;lt;0.05. Patients with a final MCI or dementia diagnosis more often employed a home health aide than NC patients, with a <jats:italic>p<\/jats:italic>-value of &amp;lt;0.05. Moreover, Mantel\u2013Haenzsel tests revealed linear associations between the occurrence of these outcomes and the level of cognitive impairment, with a <jats:italic>p<\/jats:italic>-value of &amp;lt;0.001 (i.e., dementia &amp;gt; MCI &amp;gt; NC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cognitive diagnosis was associated with reported life events of ET patients, including the use of a mobility aid, employment of a home health aide, and removal from an independent living situation. These data provide rare insights into the important role cognitive decline plays in the experiences of ET patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1193220","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:34:02Z","timestamp":1686720842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between cognitive diagnosis and a range of significant life events in an elderly essential tremor cohort: a longitudinal, prospective analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Diane S.","family":"Berry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diep","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/j.1468-1331.2012.03855.x","article-title":"The primary type of tremor in essential tremor is kinetic rather than postural: cross-sectional observation of tremor phenomenology in 369 cases","volume":"20","author":"Louis","year":"2013","journal-title":"Eur J Neurol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.106","article-title":"Cognitive features of essential tremor: a review of the clinical aspects and possible mechanistic underpinnings","author":"Bermejo-Pareja","year":"2012","journal-title":"Tremor Hyperkinetic Mov N Y N."},{"key":"B3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.parkreldis.2019.02.038","article-title":"Mind the gaps: What we don't know about cognitive impairment in essential tremor","volume":"63","author":"Louis","year":"2019","journal-title":"Parkinsonism Relat Disord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1177\/1756285613489591","article-title":"The cognitive side of essential tremor: what are the therapeutic implications?","volume":"6","author":"Janicki","year":"2013","journal-title":"Ther. 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