{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:42Z","timestamp":1753891722612,"version":"3.41.2"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Neuroblastoma (NB) is a leading cause of death in children. It usually occurs in the adrenal gland and rarely in the spinal canal. Here, we report the case of a 48-year-old male patient with abnormal thickening of the cauda equina nerve as revealed by lumbosacral magnetic resonance imaging. The patient\u2019s main clinical manifestations were numbness and pain in both lower limbs. The patient underwent surgical treatment; however, intraoperatively, an unclear border was observed between the cauda equina nerve and the tumor; therefore, the tumor was not forcibly excised. The postoperative pathological results were reported as NB. The disease known as NB, which is extremely rare. We believe that a pathological biopsy is extremely vital for diagnosing NB, and aggressive post-operative radio-chemotherapy could potentially prolong the patient\u2019s survival time.<\/jats:p>","DOI":"10.3389\/fneur.2023.1195664","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T23:05:20Z","timestamp":1691103920000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroblastoma of the lumbosacral canal in an adult: a case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Qingyu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haofeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijia","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1016\/S0140-6736(07)60983-0","article-title":"Neuroblastoma","volume":"369","author":"Maris","year":"2007","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3109\/10408363.2012.683483","article-title":"Neuroblastoma: the impact of biology and cooperation leading to personalized treatments","volume":"49","author":"Owens","year":"2012","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.pcl.2014.09.015","article-title":"Neuroblastoma: paradigm for precision medicine","volume":"62","author":"Irwin","year":"2015","journal-title":"Pediatr Clin N Am"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1471-2407-11-160","article-title":"Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil","volume":"11","author":"de Camargo","year":"2011","journal-title":"BMC Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/cncr.11521","article-title":"Neuroblastoma in adolescents","volume":"98","author":"Gaspar","year":"2003","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(SICI)1097-0142(19960715)78:2<311::AID-CNCR19>3.0.CO;2-Z","article-title":"The treatment of neuroblastoma with intraspinal extension with chemotherapy followed by surgical removal of residual disease. 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