{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:57:00Z","timestamp":1788440220379,"version":"build-2803163510"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aims to assess the quality of life (QoL) in patients who have undergone decompressive craniectomy (DC) for any pathology that has caused life-threatening intracranial hypertension. Similarly, it aims to evaluate QoL perceived by caregivers or external informants. In addition to that, the last purpose is to determine which clinical or therapeutic factors could correlate with a better QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single-center cross-sectional study was designed. All patients over 18 years old who underwent a supratentorial DC at our department due to intracranial hypertension of any etiology, from January 2015 to December 2021, were retrospectively selected. Patients with incomplete follow-up (under 1 year from the event or those who died) or who declined to participate in the study were excluded. QoL was assessed with SF-36 and CAVIDACE scales. The correlation between clinical and therapeutic variables and SF-36 subscales was studied with Spearman's correlation and the Mann\u2013Whitney U-test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 consecutive patients were recruited: 22 patients had died, three were missed for follow-up, and 15 declined to participate, thus 15 subjects were finally included. The mean follow-up was 47 months (IQR 21.5\u201367.5). A significant reduction in the \u201crole physical\u201d and \u201crole emotional\u201d subscales of SF-36 was observed compared with the general population. According to caregivers, a significant reduction was assigned to the \u201cphysical wellbeing\u201d and \u201crights\u201d domains. The \u201cphysical functioning\u201d score was poorer in women, older patients, those with dominant hemisphere disease, those who required tracheostomy, and those with poor outcomes in the modified Rankin scale. A strong correlation was found between the QoL index at the CAVIDACE scale and the SF-36 subscales \u201cphysical functioning\u201d and \u201crole physical\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most patients and caregivers reported acceptable QoL after DC due to a life-threatening disease. A significant reduction in SF- 36 subscales scores \u201crole limitation due to physical problems\u201d and \u201crole limitation due to emotional problems\u201d was referred by patients. According to caregivers' QoL perception, only 25% of the survey's participants showed low scores in the QoL index of the CAVIDACE scale. Only 26.7% of the patients showed mood disorders.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1222080","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T09:50:40Z","timestamp":1690365040000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Long-term quality of life after decompressive craniectomy"],"prefix":"10.3389","volume":"14","author":[{"given":"Daniel","family":"Buffagni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Zamarron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Melgosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Gutierrez-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3389\/fneur.2019.00458","article-title":"The history of decompressive craniectomy in traumatic brain injury","volume":"10","author":"Rossini","year":"2019","journal-title":"Front Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1474-4422(07)70036-4","article-title":"Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials","volume":"6","author":"Vahedi","year":"2007","journal-title":"Lancet Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/2009.3.FOCUS945","article-title":"Quality of life after hemicraniectomy for traumatic brain injury in adults. 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