{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:29:27Z","timestamp":1787167767176,"version":"build-2736575974"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"\n Objective<\/jats:title>\n \n Regional cerebral oxygen saturation (rSO\n 2<\/jats:sub>\n ) is linked with blood pressure. This study evaluated the influence of perioperative rSO\n 2<\/jats:sub>\n monitoring on the prognosis of ischemic Moyamoya disease (MMD) patients undergoing anastomosis surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective cohort, patients with unilateral ischemic MMD of Suzuki stage \u22653 were included. The decision of rSO\n 2<\/jats:sub>\n was made by the clinician and the patient. The rSO\n 2<\/jats:sub>\n group maintained intraoperative rSO\n 2<\/jats:sub>\n levels through the modulation of blood pressure, inhaled oxygen concentration, carbon dioxide in arterial blood, and red blood cell transfusion. The non-rSO\n 2<\/jats:sub>\n group used conventional anesthesia practices. Perioperative mean arterial pressure (MAP), rSO\n 2<\/jats:sub>\n values, neurological complications, and postoperative results were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 75 eligible patients were categorized into a rSO\n 2<\/jats:sub>\n monitoring group (\n n<\/jats:italic>\n = 30) and a non-rSO\n 2<\/jats:sub>\n monitoring group (\n n<\/jats:italic>\n = 45). For the rSO\n 2<\/jats:sub>\n group, the preoperative rSO\n 2<\/jats:sub>\n was significantly lower on the affected side (\n P<\/jats:italic>\n &lt; 0.05). After anastomosis, this value notably increased (\n P<\/jats:italic>\n = 0.01). A moderate relationship was observed between perioperative rSO\n 2<\/jats:sub>\n and MAP before, during, and after surgery, with correlation coefficients (\n r<\/jats:italic>\n ) of 0.536, 0.502, and 0.592 (\n P<\/jats:italic>\n &lt; 0.05). Post-surgery MAP levels differed between the groups, with the rSO\n 2<\/jats:sub>\n group showing decreased levels compared to pre-surgery and the non-rOS\n 2<\/jats:sub>\n group displaying elevated levels. Notably, the rSO\n 2<\/jats:sub>\n group reported shorter hospitalizations and decreased neurological complications. Patients with a hypertension history found postoperative MAP influencing hospital stay duration.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Perioperative rSO\n 2<\/jats:sub>\n surveillance enhanced cerebral perfusion and minimized postoperative complications in ischemic MMD patients. Thus, rSO\n 2<\/jats:sub>\n monitoring is advocated for MMD patients undergoing vascular anastomosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fneur.2023.1226455","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T22:22:17Z","timestamp":1695334937000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of cerebral oxygen saturation monitoring in patients undergoing superficial temporal anterior-middle cerebral artery anastomosis for ischemic Moyamoya disease: a prospective cohort study"],"prefix":"10.3389","volume":"14","author":[{"given":"Xuanling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.2174\/1570159X19666210716114016","article-title":"Progression in Moyamoya disease: clinical features, neuroimaging evaluation, and treatment","volume":"20","author":"Zhang","year":"2022","journal-title":"Curr Neuropharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"100331","DOI":"10.1016\/j.lanwpc.2021.100331","article-title":"Epidemiology of Moyamoya disease in China: a nationwide hospital-based study","volume":"11","author":"Zhang","year":"2022","journal-title":"Lancet Reg Health West Pac."},{"key":"B3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10143-018-0994-5","article-title":"Progress in Moyamoya disease","volume":"43","author":"Shang","year":"2020","journal-title":"Neurosurg Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/NEJMra0804622","article-title":"Moyamoya disease and moyamoya syndrome","volume":"360","author":"Scott","year":"2009","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1055\/s-2005-868160","article-title":"Surgical management of moyamoya syndrome","volume":"15","author":"Smith","year":"2005","journal-title":"Skull Base."},{"key":"B6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/jnnp-2019-321069","article-title":"Revascularisation surgery improves cognition in adult patients with moyamoya disease","volume":"91","author":"Ando","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B7","doi-asserted-by":"publisher","first-page":"E17","DOI":"10.3171\/FOC\/2008\/24\/2\/E17","article-title":"Progression of disease in unilateral moya-moya syndrom. 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