{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:09:20Z","timestamp":1753891760645,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Paraneoplastic neurological disorders are rare in children, with paraneoplastic cerebellar degeneration (PCD) considered highly atypical. We describe a 13-year-old girl with progressive neurobehavioral regression, cerebellar ataxia, and intractable epilepsy presenting in super-refractory status epilepticus. After an extensive evaluation, her clinical picture was suggestive of probable autoimmune encephalitis (AE). Further diagnostic testing revealed a molecularly undefined neural-restricted autoantibody in both serum and CSF, raising suspicion over an adrenal mass previously considered incidental. Surgical resection led to a robust clinical improvement, and pathology revealed a benign ganglioneuroma. This report widens the spectrum of paraneoplastic manifestations of ganglioneuroma, reviews the diagnostic approach to antibody-negative pediatric AE, and raises important clinical considerations regarding benign and incidentally found tumors in the setting of a suspected paraneoplastic neurologic syndrome.<\/jats:p>","DOI":"10.3389\/fneur.2023.1250261","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:58:34Z","timestamp":1697702314000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A not so incidental \u2018incidentaloma\u2019 \u2212 pediatric ganglioneuroma-associated cerebellar degeneration and super-refractory status epilepticus: case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Albert","family":"Aboseif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron W.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Lachhwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia Margarita Pestana","family":"Knight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahsan Moosa Naduvil","family":"Valappil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Zeft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S0140-6736(06)69043-0","article-title":"Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study","volume":"368","author":"Chin","year":"2006","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.seizure.2018.05.012","article-title":"Pediatric refractory, and super-refractory status epilepticus","volume":"68","author":"Vasquez","year":"2019","journal-title":"Seizure"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.eplepsyres.2017.07.006","article-title":"Status epilepticus-related etiology, incidence and mortality: a meta-analysis","volume":"136","author":"Lv","year":"2017","journal-title":"Epilepsy Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"9768949","DOI":"10.1155\/2018\/9768949","article-title":"Updates in refractory status epilepticus","volume":"2018","author":"Marawar","year":"2018","journal-title":"Crit Care Res Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jocn.2015.06.032","article-title":"Causes and outcomes of new onset status epilepticus and predictors of refractoriness to therapy","volume":"26","author":"Jayalakshmi","year":"2016","journal-title":"J Clin Neurosci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.22037\/ijcn.v9i4.7173","article-title":"Refractory convulsive status epilepticus in children: etiology, associated risk factors and outcome","volume":"9","author":"Barzegar","year":"2015","journal-title":"Iran J Child Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e104169","DOI":"10.1371\/journal.pone.0104169","article-title":"Encephalitis hospitalization rates and inpatient mortality in the United States, 2000-2010. 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