{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:59:28Z","timestamp":1792511968281,"version":"4.5.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260202"],"award-info":[{"award-number":["82260202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Aquaporin-4 (AQP4) antibody-seropositive optic neuritis (AQP4-ON) is one of the most common types of optic neuritis in China. However, the association between AQP4-ON and vision-related quality of life (QoL) and depression remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross-sectional study, 57 patients with optic neuritis were evaluated for their vision-related QoL using a Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and assessed for depressive symptoms using a Chinese version of the Beck Depression Inventory-II (BDI-II). Data regarding participants\u2019 age, sex, visual acuity, and the number of recurrence events were gathered. Linear regression analysis was employed to investigate the relationships between AQP4-ON and vision-related QoL, as well as depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 57 included patients, 28 were AQP4-ON, and 29 were idiopathic optic neuritis (ION). AQP4-ON demonstrated a significant correlation with a decreased VFQ-25 composite score (Mean difference, \u221211.65 [95% CI, \u221221.61 to \u22121.69]; <jats:italic>p<\/jats:italic>\u2009=\u20090.023) and an increased BDI-II score (Mean difference, 6.48 [95% CI, 0.25 to 12.71]; <jats:italic>p<\/jats:italic>\u2009=\u20090.042) when compared to ION. The BDI-II score was correlated with the VFQ-25 composite score (Spearman \u03c1\u2009=\u2009\u22120.469; <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) but not with the visual acuity in the worse-seeing eye (Spearman \u03c1\u2009=\u20090.024; <jats:italic>p<\/jats:italic>\u2009=\u20090.860) or in the better-seeing eye (Spearman \u03c1\u2009=\u2009\u22120.039; <jats:italic>p<\/jats:italic>\u2009=\u20090.775), bilateral severe visual impairment (Spearman \u03c1\u2009=\u20090.039; <jats:italic>p<\/jats:italic>\u2009=\u20090.772) or the number of recurrence events (Spearman \u03c1\u2009=\u20090.184; <jats:italic>p<\/jats:italic>\u2009=\u20090.171).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AQP4-positive optic neuritis is associated with a decline in vision-related quality of life as well as an increased likelihood of experiencing depression. It is crucial for clinicians to assess both vision-related QoL and depression in patients with AQP4-positive optic neuritis to provide patient-centered care.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1265170","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:13:45Z","timestamp":1696238025000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of aquaporin-4 antibody-seropositive optic neuritis with vision-related quality of life and depression"],"prefix":"10.3389","volume":"14","author":[{"given":"Ruitong","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref1","first-page":"1017","article-title":"The National eye Institute visual function questionnaire: experience of the Ontt. 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