{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:27:56Z","timestamp":1791919676618,"version":"4.3.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>The male reproductive functions are largely regulated by the autonomic nervous system. Male sexual behavior and fertility primarily depend on the normal function of the higher neural centers related to the autonomic nervous system, the hypothalamic\u2013pituitary\u2013gonadal axis, the autonomic nervous components within the spinal cord and spinal nerves, and certain somatic nerves in the pelvic floor. In this review article, we will summarize the role of the autonomic nervous system in regulating male reproductive capabilities and fertility, its impact on male infertility under abnormal conditions, including the role of drug-induced autonomic nervous dysfunctions on male infertility. The main purpose of this article was to provide an overview of the effects of autonomic nervous dysfunction on male reproductive function and shed light on the potential therapeutic target for male infertility.<\/jats:p>","DOI":"10.3389\/fneur.2023.1277795","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:29:07Z","timestamp":1698046147000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of autonomic nervous system disorders on male infertility"],"prefix":"10.3389","volume":"14","author":[{"given":"Qixiang","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"B1","unstructured":"2023"},{"key":"B2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41572-023-00459-w","article-title":"Male infertility","volume":"9","author":"Eisenberg","year":"2023","journal-title":"Nat Rev Dis Primers."},{"key":"B3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/B978-0-444-63247-0.00025-0","article-title":"Management of male neurologic patients with infertility","volume":"130","author":"Fode","year":"2015","journal-title":"Handb Clin Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/IJGM.S241099","article-title":"Khodadadian A. Some of the factors involved in male infertility: a prospective review","volume":"13","author":"Babakhanzadeh","year":"2020","journal-title":"IJGM."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1111\/j.1743-6109.2009.01309.x","article-title":"Pathways of sexual desire","volume":"6","author":"Pfaus","year":"2009","journal-title":"J Sex Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"15647","DOI":"10.1523\/JNEUROSCI.2558-12.2012","article-title":"Dorsomedial prefrontal cortex mediates rapid evaluations predicting the outcome of romantic interactions","volume":"32","author":"Cooper","year":"2012","journal-title":"J Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrn3857","article-title":"Salience processing and insular cortical function and dysfunction","volume":"16","author":"Uddin","year":"2014","journal-title":"Nat Rev Neurosci."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1101\/102368","article-title":"From affect to control: Functional specialization of the insula in motivation and regulation","author":"Wager","year":"2017","journal-title":"bioRxiv."},{"key":"B9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/ca.22528","article-title":"Functional neuroanatomy of human cortex cerebri in relation to wanting sex and having it","volume":"28","author":"Georgiadis","year":"2015","journal-title":"Clin Anat."},{"key":"B10","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neuroscience.2010.01.050","article-title":"Persistent genital arousal disorder associated with functional hyperconnectivity of an epileptic focus","volume":"167","author":"Anzellotti","year":"2010","journal-title":"Neuroscience."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1136\/jnnp.2006.107193","article-title":"Neurological control of human sexual behaviour: insights from lesion studies","volume":"78","author":"Baird","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B12","first-page":"73","article-title":"Levels of FSH, LH and testosterone, and sperm DNA fragmentation","volume":"35","author":"Wdowiak","year":"2014","journal-title":"Neuroendocrinol Lett."},{"key":"B13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/path.2077","article-title":"The ageing male reproductive tract","volume":"211","author":"Sampson","year":"2007","journal-title":"J Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.yfrne.2013.11.001","article-title":"Gonadal steroid hormones and the hypothalamo\u2013pituitary\u2013adrenal axis","volume":"35","author":"Handa","year":"2014","journal-title":"Front Neuroendocrinol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12958-018-0435-x","article-title":"Sport, doping and male fertility","volume":"16","author":"Sansone","year":"2018","journal-title":"Reprod Biol Endocrinol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e13617","DOI":"10.1111\/and.13617","article-title":"Obesity and male infertility: mechanisms and management","volume":"53","author":"Leisegang","year":"2020","journal-title":"Andrologia."},{"key":"B17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1097\/MOU.0000000000000417","article-title":"Obesity and male infertility","volume":"27","author":"Kahn","year":"2017","journal-title":"Curr Opin Urol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrurol.2015.112","article-title":"Effects of psychological stress on male fertility","volume":"12","author":"Nargund","year":"2015","journal-title":"Nat Rev Urol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11154-019-09530-y","article-title":"Fertility issues in aggressive pituitary tumors","volume":"21","author":"Marques","year":"2020","journal-title":"Rev Endocr Metab Disord."},{"key":"B20","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/andr.13262","article-title":"Understanding and treating ejaculatory dysfunction in men with diabetes mellitus","volume":"11","author":"Desai","year":"2022","journal-title":"Andrologia."},{"key":"B21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2164\/jandrol.111.013193","article-title":"Diabetes mellitus and sperm parameters","volume":"33","author":"La Vignera","year":"2011","journal-title":"J Androl."},{"key":"B22","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1212\/01.WNL.0000137341.89781.14","article-title":"Topiramate vs placebo in painful diabetic neuropathy: analgesic and metabolic effects","volume":"63","author":"Raskin","year":"2004","journal-title":"Neurology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1212\/01.WNL.0000098936.46730.64","article-title":"Effect of epilepsy and antiepileptic drugs on male reproductive health","volume":"62","author":"Isojarvi","year":"2004","journal-title":"Neurology."},{"key":"B24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1586\/17512433.2016.1160777","article-title":"The effect of epilepsy and antiepileptic drugs on sexual, reproductive and gonadal health of adults with epilepsy","volume":"9","author":"Hamed","year":"2016","journal-title":"Expert Rev Clin Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.reprotox.2011.02.002","article-title":"Hormonal and reproductive disturbances in epileptic male patients: emerging issues","volume":"31","author":"Verrotti","year":"2011","journal-title":"Reprod Toxicol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/j.1743-6109.2011.02450.x","article-title":"Neurophysiology of erection and ejaculation","volume":"8","author":"El-Khayat","year":"2011","journal-title":"J Sex Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1097\/01.ju.0000173072.73702.64","article-title":"Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia","volume":"174","author":"McVary","year":"2005","journal-title":"J Urol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1236361","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science."},{"key":"B29","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.fertnstert.2021.07.1199","article-title":"The role of benign prostatic hyperplasia treatments in ejaculatory dysfunction","volume":"116","author":"Bearelly","year":"2021","journal-title":"Fertil Steril."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1016\/j.juro.2010.02.018","article-title":"Treatment for ejaculatory dysfunction in men with spinal cord injury: an 18-year single center experience","volume":"183","author":"Brackett","year":"2010","journal-title":"J Urol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1080\/10790268.2017.1320875","article-title":"Oral probenecid improves sperm motility in men with spinal cord injury","volume":"41","author":"Ibrahim","year":"2017","journal-title":"J Spinal Cord Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2164\/jandrol.107.003574","article-title":"Higher sperm DNA damage in semen from men with spinal cord injuries compared with controls","volume":"29","author":"Brackett","year":"2007","journal-title":"J Androl."},{"key":"B33","doi-asserted-by":"publisher","first-page":"382","DOI":"10.4103\/1008-682X.178851","article-title":"Advances in the management of infertility in men with spinal cord injury","volume":"18","author":"Brackett","year":"2016","journal-title":"Asian J Androl."},{"key":"B34","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.fertnstert.2013.06.009","article-title":"Differential seminal plasma proteome according to semen retrieval in men with spinal cord injury","volume":"100","author":"da Silva","year":"2013","journal-title":"Fertil Steril."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/sc.2016.78","article-title":"Evidence of a new pattern of ejaculation in men with spinal cord injury: ejaculation dyssynergia and implications for fertility","volume":"54","author":"Soler","year":"2016","journal-title":"Spinal Cord."},{"key":"B36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/JNN.0000000000000367","article-title":"Sexual function in young individuals with multiple sclerosis: does disability matter?","volume":"50","author":"Calabr\u00f2","year":"2018","journal-title":"J Neurosci Nurs."},{"key":"B37","doi-asserted-by":"publisher","first-page":"i3","DOI":"10.1007\/s00415-006-1102-2","article-title":"Autonomic dysfunction in multiple sclerosis","volume":"253","author":"Haensch","year":"2006","journal-title":"J Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/j.1365-2826.2008.01791.x","article-title":"Evaluation of endocrine profile, hypothalamic-pituitary-testis axis and semen quality in multiple sclerosis","volume":"20","author":"Safarinejad","year":"2008","journal-title":"J Neuroendocrinol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.3390\/jcm10225401","article-title":"Effect of multiple sclerosis and its treatments on male fertility: cues for future research","volume":"10","author":"Massarotti","year":"2021","journal-title":"JCM."},{"key":"B40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jpurol.2020.12.021","article-title":"Sexual function and dysfunction in men with spina bifida","volume":"17","author":"Roth","year":"2021","journal-title":"J Pediatr Urol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1111\/j.1743-6109.2009.01351.x","article-title":"Erectile function recovery rate after radical prostatectomy: a meta-analysis","volume":"6","author":"Tal","year":"2009","journal-title":"J Sex Med."},{"key":"B42","first-page":"3","article-title":"Effects of pharmaceutical medications on male fertility","volume":"13","author":"Brezina","year":"2012","journal-title":"J Reprod Infertil."},{"key":"B43","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1590\/S0041-87812004000600011","article-title":"Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility","volume":"59","author":"Pasqualotto","year":"2004","journal-title":"Rev Hosp Clin."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1277795\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T10:39:42Z","timestamp":1701859182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1277795\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":43,"alternative-id":["10.3389\/fneur.2023.1277795"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1277795","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]},"article-number":"1277795"}}