{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:36:24Z","timestamp":1775500584081,"version":"3.50.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Many endolymphatic hydrops (EH) MRI studies in the literature do not include a normal control group. Consequently, it remains unclear which outcome measure in EH MRI can most effectively distinguish between MD patients and normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gadolinium-enhanced EH imaging was performed to quantitatively evaluate the extents of hydrops in MD patients and age\u2212\/sex-matched normal controls. Four hours after intravenous injection of contrast agent, MRI was performed using a 3-T MR platform fitted with a 32-channel phased-array coil receptor. MR images (10\u201315 slices) covering an inner ear were 3D-stacked. Analyses of all images that included the vestibule or the cochlea yielded the volumes (in \u03bcL) of the endolymphatic and perilymphatic spaces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the vestibule, they were significantly greater EH% in ipsilateral (52.4\u2009\u00b1\u200912.5) than in contralateral MD ears (40.4\u2009\u00b1\u20098.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and in ipsilateral MD ears than in control ears (42.4\u2009\u00b1\u200913.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.025). For the cochlea, the values were slightly higher EH% in ipsilateral MD ears (49.7\u2009\u00b1\u200910.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.061) but did not significantly differ from contralateral (41.3\u2009\u00b1\u200912.6) or control ears (39.6\u2009\u00b1\u200918.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.858). In the MD group, the EH asymmetries were 12.0\u2009\u00b1\u200910.2% (vestibule) and 8.4\u2009\u00b1\u20098.6% (cochlea), significantly larger than those of controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to conventional semiquantitative grading or quantitative EH% analysis, EH asymmetry may better distinguish MD patients from normal controls. Quantitative hydrops volumetric analysis yields clinically relevant information on inner ear function.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1280616","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:52:59Z","timestamp":1703134379000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Endolymphatic hydrops asymmetry distinguishes patients with Meniere\u2019s disease from normal controls with high sensitivity and specificity"],"prefix":"10.3389","volume":"14","author":[{"given":"Tae-Soo","family":"Noh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Kyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ha","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Chan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Whan","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.7874\/jao.2022.00010","article-title":"Does listening to tinnitus frequency-filtered music relieve tinnitus?","volume":"26","author":"Yoo","year":"2022","journal-title":"J Audiol Otol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1177\/000348948909801108","article-title":"Meniere's syndrome and endolymphatic hydrops. 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