{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:08Z","timestamp":1753891568812,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Literature on invasive neuromonitoring and bilateral decompressive craniectomies (BDC) in patients with refractory status epilepticus (RSE)-mediated hypoxic-ischemic brain injury (HIBI) is limited. Neuromonitoring can guide decision making and treatment escalation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We report a case of a 17\u2009years-old male who was admitted to our hospital\u2019s intensive care unit for RSE. HIBI was detected on neuroimaging on this patient\u2019s second day of admission after he developed central diabetes insipidus (DI). Invasive neuromonitoring revealed raised intracranial pressure (ICP) and brain hypoxia as measured by reduced brain tissue oxygen tension (PbtO<jats:sub>2<\/jats:sub>). Treatments were escalated in a tiered fashion, including administration of hyperosmolar agents, analgesics, sedatives, and a neuromuscular blocking drug. Eventually, BDC was performed as a salvage therapy as a means of controlling refractory ICP crisis in the setting of diffuse cerebral edema (DCE) following HIBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>SE-mediated HIBI can result in refractory ICP crisis. Neuromonitoring can help identify secondary brain injury (SBI), guide treatment strategies, including surgical interventions, and may lead to better outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1284098","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T08:56:35Z","timestamp":1701334595000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Invasive neuromonitoring in status epilepticus induced hypoxic ischemic brain injury"],"prefix":"10.3389","volume":"14","author":[{"given":"Karandeep Singh","family":"Bhatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swarna","family":"Rajagopalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e20161933","DOI":"10.1542\/peds.2016-1933","article-title":"Fatal cerebral edema with status epilepticus in children with Dravet syndrome: report of 5 cases","volume":"139","author":"Myers","year":"2017","journal-title":"Pediatrics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1203\/00006450-198607000-00001","article-title":"31P nuclear magnetic resonance study of the effect of hypoxemia on neonatal status epilepticus","volume":"20","author":"Young","year":"1986","journal-title":"Pediatr 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with elevated intracranial pressure: a review of the evidence","volume":"52","author":"Witherspoon","year":"2017","journal-title":"Nurs Clin North Am"},{"key":"ref17","first-page":"60","article-title":"Einfluss von Disoprivan (Propofol) auf die Durchblutung und den Sauerstoffverbrauch des Gehirns und die CO2-Reaktivit\u00e4t der Hirngef\u00e4sse beim menschen [Effect of disoprivan (propofol) on the circulation and oxygen consumption of the brain and CO2 reactivity of brain vessels in the human]","volume":"36","author":"Stephan","year":"1987","journal-title":"Anaesthesist"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1213\/00000539-199007000-00008","article-title":"Effect of propofol on cerebral circulation and autoregulation in the baboon","volume":"71","author":"Van Hemelrijck","year":"1990","journal-title":"Anesth Analg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s12028-020-00975-7","article-title":"Ketamine as an 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