{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:57:01Z","timestamp":1789696621400,"version":"4.0.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inclusion body myositis (IBM) is a chronic inflammatory muscle disease that is characterized by mixed myogenic and neurogenic electromyography (EMG) findings. We investigated the association between EMG findings and the IBM stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included consecutive patients diagnosed with IBM based on muscle biopsy and had needle EMG performed within 1\u2009month of biopsy. Motor unit potential waveform (MUP) in EMG and pathological findings were compared between patients in early and late phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 30 patients with biopsy-confirmed IBM and 254 muscles were included. The rate of abnormal discharge did not differ according to disease stage. There was a difference in the frequency of occurrence between myogenic suggestive MUP and neurogenic of biceps and flexor digitorum profundus in the late phase. Abnormal MUP was observed even in muscles without muscle weakness, and myogenic changes were predominant in biceps and gastrocnemius with muscle weakness. The biopsy findings on the contralateral side of the muscle where electromyography was performed revealed a tendency for muscles that exhibited myogenic origin to have more inflammatory cells and RV; however, the difference was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The target muscles for EMG must be selected considering the disease stage as well. In the early stages of IBM, EMG results should be interpreted cautiously, as neurogenic suggestive pattern of MUP might also be exhibited. Contralateral electromyography findings may be helpful in selecting muscles for muscle biopsies, such as biceps and quadriceps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2023.1295396","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:52:40Z","timestamp":1704415960000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Electromyography varies by stage in inclusion body myositis"],"prefix":"10.3389","volume":"14","author":[{"given":"Tomoo","family":"Mano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Eura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanami","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirosei","family":"Horikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Sugie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1016\/j.clinph.2015.12.011","article-title":"Sporadic inclusion body myositis: a review of recent clinical advances and current approaches to diagnosis and treatment","volume":"127","author":"Needham","year":"2016","journal-title":"Clin Neurophysiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/mus.27716","article-title":"Atypical presentations of inclusion body myositis: clinical characteristics and long-term outcomes","volume":"66","author":"Alamr","year":"2022","journal-title":"Muscle Nerve"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/CND.0000000000000113","article-title":"Clinical and electrophysiological findings in hereditary inclusion body myopathy compared with sporadic inclusion body myositis","volume":"17","author":"Kazamel","year":"2016","journal-title":"J Clin Neuromuscul Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/mus.880090604","article-title":"Automatic analysis of the electromyographic interference pattern. 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Combined morphological and electrophysiological studies on peripheral nerves","volume":"99","author":"Lindberg","year":"1990","journal-title":"J Neurol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1016\/j.clinph.2020.07.025","article-title":"Neuropathy in sporadic inclusion body myositis: a multi-modality neurophysiological study","volume":"131","author":"Lee","year":"2020","journal-title":"Clin Neurophysiol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1295396\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:52:44Z","timestamp":1704415964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1295396\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,5]]},"references-count":18,"alternative-id":["10.3389\/fneur.2023.1295396"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1295396","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,5]]},"article-number":"1295396"}}