{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:02:12Z","timestamp":1793916132782,"version":"4.8.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is a novel noninvasive treatment for drug-resistant Parkinson\u2019s disease (PD) related tremor. This study aims to evaluate MRgFUS\u2019s efficacy and safety in PD through a systematic review and meta-analysis, examining pre-and post-treatment MDS-UPDRSIII and\/or CRST scores and associated adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted an extensive literature search across PubMed, Embase, Web of Science, and Cochrane Library databases, screening studies based on set criteria and analyzing MDS-UPDRSIII, CRST, and adverse events pre- and post-MRgFUS treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 468 retrieved articles, 20 studies involving 258 patients, spanning 2014\u20132023, were included.17 studies indicated significant MDS-UPDRSIII score reductions post-MRgFUS treatment, while 3 showed significant CRST score declines. In the \u201con\u201d medication state, pooled MDS-UPDRSIII scores at 1, 3, 6, and 12\u2009months were 12.18 (95% CI: 5.83\u201318.52), 12.10 (95% CI: 8.22\u201315.97), 14.85 (95% CI: 9.28\u201320.41), and 20.65 (95% CI: 12.15\u201329.14) respectively. In the \u201coff\u201d state, scores were 11.45 (95% CI: \u22123.50-26.40), 14.71 (95% CI: 4.95\u201324.46), 21.52 (95% CI: 19.28\u201323.75), and 22.28 (95% CI: 15.26\u201329.30). Adverse events were typically mild and transient, with speech disturbances, ataxia, and sensory abnormalities being common post-operative neurological complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MRgFUS offers an effective and relatively safe treatment option for patients with drug-resistant PD-related tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>, No. CRD42023428332.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1301240","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T13:56:22Z","timestamp":1701957382000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and safety of magnetic resonance-guided focused ultrasound for Parkinson\u2019s disease: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiaona","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peicong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/jnc.13691","article-title":"The clinical symptoms of Parkinson's 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