{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:39:52Z","timestamp":1782830392600,"version":"3.54.5"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fragile X-associated tremor\/ataxia syndrome (FXTAS), a neurodegenerative disease that affects carriers of a 55-200 CGG repeat expansion in the <jats:italic>fragile X messenger ribonucleoprotein 1<\/jats:italic> (<jats:italic>FMR1<\/jats:italic>) gene, may be given an incorrect initial diagnosis of Parkinson\u2019s disease (PD) or essential tremor (ET) due to overlapping motor symptoms. It is critical to characterize distinct phenotypes in FXTAS compared to PD and ET to improve diagnostic accuracy. Fast as possible (FP) speed and dual-task (DT) paradigms have the potential to distinguish differences in gait performance between the three movement disorders. Therefore, we sought to compare FXTAS, PD, and ET patients using quantitative measures of functional mobility and gait under self-selected (SS) speed, FP, and DT conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with FXTAS (<jats:italic>n<\/jats:italic>\u2009=\u200922), PD (<jats:italic>n<\/jats:italic>\u2009=\u200923), ET (<jats:italic>n<\/jats:italic>\u2009=\u200920), and controls (<jats:italic>n<\/jats:italic>\u2009=\u200920) underwent gait testing with an inertial sensor system (APDM<jats:sup>\u2122<\/jats:sup>). An instrumented Timed Up and Go test (i-TUG) was used to measure movement transitions, and a 2-min walk test (2MWT) was used to measure gait and turn variables under SS, FP, and DT conditions, and dual-task costs (DTC) were calculated. ANOVA and multinomial logistic regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD participants had reduced stride lengths compared to FXTAS and ET participants under SS and DT conditions, longer turn duration than ET participants during the FP task, and less arm symmetry than ET participants in SS gait. They also had greater DTC for stride length and velocity compared to FXTAS participants. On the i-TUG, PD participants had reduced sit-to-stand peak velocity compared to FXTAS and ET participants. Stride length and arm symmetry index during the DT 2MWT was able to distinguish FXTAS and ET from PD, such that participants with shorter stride lengths were more likely to have a diagnosis of PD and those with greater arm asymmetry were more likely to be diagnosed with PD. No gait or i-TUG parameters distinguished FXTAS from ET participants in the regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first quantitative study demonstrating distinct gait and functional mobility profiles in FXTAS, PD, and ET which may assist in more accurate and timely diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2023.1308698","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T13:18:40Z","timestamp":1701955120000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Digital gait markers to potentially distinguish fragile X-associated tremor\/ataxia syndrome, Parkinson\u2019s disease, and essential tremor"],"prefix":"10.3389","volume":"14","author":[{"given":"Erin E.","family":"Robertson-Dick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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study","volume":"53","author":"Cornblath","year":"1999","journal-title":"Neurology"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1001\/archneur.65.4.495","article-title":"Abnormal nerve conduction features in fragile X premutation carriers","volume":"65","author":"Soontarapornchai","year":"2008","journal-title":"Arch Neurol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jns.2017.05.023","article-title":"Peripheral neuropathy in idiopathic Parkinson\u2019s disease: a systematic review","volume":"378","author":"Zis","year":"2017","journal-title":"J Neurol Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.dsx.2015.02.004","article-title":"Balance and ankle muscle strength predict spatiotemporal gait parameters in individuals with diabetic peripheral neuropathy","volume":"9","author":"De Camargo","year":"2015","journal-title":"Diabetes Metab Syndr"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1212\/01.wnl.0000281692.98200.f5","article-title":"FMR1 CGG repeat length predicts motor dysfunction in premutation carriers","volume":"70","author":"Leehey","year":"2007","journal-title":"Neurology"},{"key":"ref47","first-page":"293","article-title":"Members of the UPDRS development committee. Unified Parkinson\u2019s disease rating scale","volume":"2","author":"Fahn","year":"1987","journal-title":"Recent Dev Parkinson\u2019s Dis"},{"key":"ref48","first-page":"271","article-title":"Clinical rating scale for tremor","volume-title":"Parkinson\u2019s disease and movement disorders","author":"Fahn","year":"1993"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/s0022-510x(96)00231-6","article-title":"International cooperative ataxia rating scale for pharmacological assessment of cerebellar syndrome","volume":"145","author":"Trouillas","year":"1997","journal-title":"J Neurol Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington\u2019s disease rating scale: reliability and consistency","volume":"11","author":"Kieburtz","year":"1996","journal-title":"Mov Disord"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/gim.0b013e31820a780f","article-title":"High-resolution methylation polymerase chain reaction for fragile X analysis: evidence for novel FMR1 methylation patterns undetected in southern blot analyses","volume":"13","author":"Chen","year":"2011","journal-title":"Genet Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12984-017-0298-y","article-title":"Biomechanics and neural control of movement, 20 years later: what have we learned and what has changed?","volume":"14","author":"Nordin","year":"2017","journal-title":"J Neuroeng Rehabil"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.gaitpost.2015.01.002","article-title":"Gait and balance in adults with Friedreich\u2019s ataxia","volume":"41","author":"Stephenson","year":"2015","journal-title":"Gait 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