{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:13:36Z","timestamp":1793967216632,"version":"4.8.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Subject<\/jats:title>\n                    <jats:p>This study aims to compare the clinical efficacy of aspiration thrombectomy and stent retriever thrombectomy as first-line approaches for anterior circulation large vessel cardiogenic cerebral embolism and cryptogenic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective observational study included patients with anterior circulation large vessel cardiogenic cerebral embolism and cryptogenic stroke treated with endovascular therapy. Patients were grouped according to the first-line approach they received: aspiration thrombectomy or stent retriever thrombectomy. The primary outcome measure was the change in the National Institute of Health Stroke Scale (NIHSS) score from preoperative to immediate postoperative and from preoperative to discharge. Secondary indicators included the rate of favorable prognosis at discharge [Modified Rankin Scale (mRS) score\u2009\u2264\u20092], successful vessel recanalization rate [modified Treatment in Cerebral Ischemia (mTICI) score\u2009\u2265\u20092b], time from successful femoral artery puncture to successful vessel recanalization, and perioperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The study included 127 cases, with 1 case withdrawal after enrollment due to a stroke of another determined cause, with 83 in the aspiration thrombectomy group and 43 cases in the stent retriever thrombectomy group. The change in NIHSS score from preoperative to immediate postoperative was 5 (1, 8) in the aspiration thrombectomy group and 1 (0, 4.5) in the stent retriever thrombectomy group. The change from preoperative to discharge was 8 (5, 12) in the aspiration thrombectomy group and 4 (0, 9) in the stent retriever thrombectomy group. The aspiration thrombectomy group exhibited significantly better prognosis rates and shorter time from successful femoral artery puncture to successful vessel recanalization. There were no significant differences between the two groups in terms of successful vessel recanalization rates and perioperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a first-line approach for anterior circulation large vessel cardiogenic cerebral embolism and cryptogenic stroke, aspiration thrombectomy leads to better improvement in neurological functional deficits and prognosis rates compared to stent retriever thrombectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2023.1324725","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:21:36Z","timestamp":1705314096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Aspiration thrombectomy versus stent retriever thrombectomy as a first-line approach for cardiogenic cerebral embolism and cryptogenic stroke in large vessels of the anterior circulation"],"prefix":"10.3389","volume":"14","author":[{"given":"Peng","family":"Zhiqiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Junchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Wenying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Dongqing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qiaowei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zhenzhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wanyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Biqing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Minqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.str.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of org 10172 in acute stroke treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/01616412.2021.1968704","article-title":"Factors influencing the outcome of cardiogenic cerebral embolism: a literature review","volume":"44","author":"Wang","year":"2022","journal-title":"Neurol Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jfma.2020.05.026","article-title":"Diagnosis and treatment for embolic stroke of undetermined source: consensus statement from the Taiwan stroke society and Taiwan society of cardiology","volume":"120","author":"Tsai","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1161\/STROKEAHA.116.013105","article-title":"Thrombus histology suggests Cardioembolic cause in cryptogenic stroke","volume":"47","author":"Boeckh-Behrens","year":"2016","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1001\/jama.2017.9644","article-title":"Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic stroke and large vessel occlusion","volume":"318","author":"Lapergue","year":"2017","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/S0140-6736(19)30297-1","article-title":"Aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion (COMPASS): a multicentre, randomised, open label, blinded outcome, non-inferiority trial","volume":"393","author":"Turk","year":"2019","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1001\/jama.2021.13827","article-title":"Effect of Thrombectomy with combined contact aspiration and stent retriever vs stent retriever alone on revascularization in patients with acute ischemic stroke and large vessel occlusion: the ASTER2 randomized clinical trial","volume":"326","author":"Lapergue","year":"2021","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1001\/jamaneurol.2017.3967","article-title":"Penumbra separator 3D investigators. Safety and efficacy of a 3-dimensional stent retriever with aspiration-based Thrombectomy vs aspiration-based Thrombectomy alone in acute ischemic stroke intervention: a randomized clinical trial","volume":"75","author":"Nogueira","year":"2018","journal-title":"JAMA Neurol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early Management of Patients with Acute Ischemic Stroke: 2019 update to the 2018 guidelines for the early Management of Acute Ischemic Stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1136\/neurintsurg-2013-011024","article-title":"Primary manual aspiration thrombectomy (MAT) for acute ischemic stroke: safety, feasibility and outcomes in 112 consecutive patients","volume":"7","author":"Jankowitz","year":"2015","journal-title":"J Neurointerv Surg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/1591019916632370","article-title":"First-line lesional aspiration in acute stroke thrombectomy using a novel intermediate catheter: initial experiences with the SOFIA","volume":"22","author":"Kabbasch","year":"2016","journal-title":"Interv Neuroradiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"I","DOI":"10.1177\/2396987321989865","article-title":"European stroke organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke","volume":"6","author":"Berge","year":"2021","journal-title":"Eur Stroke J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1056\/NEJMoa1212793","article-title":"A trial of imaging selection and endovascular treatment for ischemic stroke","volume":"368","author":"Kidwell","year":"2013","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1177\/1747493018765235","article-title":"Imaging selection for acute stroke intervention","volume":"13","author":"Campbell","year":"2018","journal-title":"Int J Stroke"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1161\/01.str.20.7.864","article-title":"Measurements of acute cerebral infarction: a clinical examination scale","volume":"20","author":"Brott","year":"1989","journal-title":"Stroke"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1161\/STROKEAHA.121.037904","article-title":"Internal carotid artery tortuosity: impact on mechanical Thrombectomy","volume":"53","author":"Koge","year":"2022","journal-title":"Stroke"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/neurintsurg-2015-012122","article-title":"Comparison of clinical outcomes in patients with acute ischemic strokes treated with mechanical thrombectomy using either Solumbra or ADAPT techniques","volume":"8","author":"Delgado Almandoz","year":"2016","journal-title":"J Neurointerv Surg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"643633","DOI":"10.3389\/fneur.2021.643633","article-title":"Endovascular Management of Intracranial Atherosclerosis-Related Large Vessel Occlusion with the a direct aspiration first-pass Thrombectomy compared with Solumbra technique","volume":"12","author":"Li","year":"2021","journal-title":"Front Neurol"},{"key":"ref20","first-page":"209","article-title":"Factors affecting the prognosis of patients with acute cerebrovascular occlusion with high National Institutes of Health stroke scale scores treated with SWIM technology","volume":"29","author":"Yao","year":"2023","journal-title":"Altern Ther Health Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/s0140-6736(98)08020-9","article-title":"Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian acute stroke study investigators","volume":"352","author":"Hacke","year":"1998","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"i4","DOI":"10.1136\/neurintsurg-2014-011125.rep","article-title":"ADAPT FAST study: a direct aspiration first pass technique for acute stroke thrombectomy","volume":"10","author":"Turk","year":"2018","journal-title":"J Neurointerv Surg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1136\/neurintsurg-2018-014696","article-title":"Need for rescue treatment and its implication: stent retriever versus contact aspiration thrombectomy","volume":"11","author":"Kang","year":"2019","journal-title":"J Neurointerv Surg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fneur.2019.00308","article-title":"Endovascular treatment of acute stroke due to intracranial atherosclerotic stenosis-related large vessel occlusion","volume":"10","author":"Park","year":"2019","journal-title":"Front Neurol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e75654","DOI":"10.1371\/journal.pone.0075654","article-title":"Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2\/9 and Ras\/MEK\/ERK signaling pathways","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jacc.2019.11.024","article-title":"Embolic stroke of undetermined source: JACC review topic of the week","volume":"75","author":"Ntaios","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e016780","DOI":"10.1136\/bcr-2020-016780","article-title":"First clinical report of aspiration through a novel 0.088-inch catheter positioned in the M1 middle cerebral artery for ELVO thrombectomy","volume":"13","author":"Gershon","year":"2020","journal-title":"BMJ Case Rep"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1177\/1591019918811802","article-title":"3MAX catheter for thromboaspiration of downstream and new territory emboli after mechanical thrombectomy of large vessel occlusions: initial experience","volume":"25","author":"Settecase","year":"2019","journal-title":"Interv Neuroradiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"jnis-2023-020360","DOI":"10.1136\/jnis-2023-020360","article-title":"Effects of intravenous thrombolysis on stent retriever and aspiration thrombectomy outcomes: a systematic review and meta-analysis of the randomized controlled trials","author":"Bilgin","year":"2023","journal-title":"J Neurointerv Surg"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1324725\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:21:40Z","timestamp":1705314100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1324725\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,15]]},"references-count":29,"alternative-id":["10.3389\/fneur.2023.1324725"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1324725","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,15]]},"article-number":"1324725"}}