{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:17:27Z","timestamp":1773361047936,"version":"3.50.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG065290"],"award-info":[{"award-number":["AG065290"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG070229"],"award-info":[{"award-number":["AG070229"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS085171"],"award-info":[{"award-number":["NS085171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS086965"],"award-info":[{"award-number":["NS086965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Epilepsy is a chronic neurological disorder characterized by recurrent seizures, and is often comorbid with other neurological and neurodegenerative diseases, such as Alzheimer's disease (AD). Patients with recurrent seizures often present with cognitive impairment. However, it is unclear how seizures, even when infrequent, produce long-lasting deficits in cognition. One mechanism may be seizure-induced expression of \u0394FosB, a long-lived transcription factor that persistently regulates expression of plasticity-related genes and drives cognitive dysfunction. We previously found that, compared with cognitively-intact subjects, the activity-dependent expression of \u0394FosB in the hippocampal dentate gyrus (DG) was increased in individuals with mild cognitive impairment (MCI) and in individuals with AD. In MCI patients, higher \u0394FosB expression corresponded to lower Mini-Mental State Examination scores. Surgically resected DG tissue from patients with temporal lobe epilepsy also showed robust \u0394FosB expression; however, it is unclear whether \u0394FosB expression also corresponds to cognitive dysfunction in non-AD-related epilepsy. To test whether DG \u0394FosB expression is indicative of cognitive impairment in epilepsies with different etiologies, we assessed \u0394FosB expression in surgically-resected hippocampal tissue from 33 patients with childhood epilepsies who had undergone Wechsler Intelligence Scale for Children (WISC) testing prior to surgery. We found that \u0394FosB expression is inversely correlated with Full-Scale Intelligence Quotient (FSIQ) in patients with mild to severe intellectual disability (FSIQ &amp;lt; 85). Our data indicate that \u0394FosB expression corresponds to cognitive impairment in epilepsies with different etiologies, supporting the hypothesis that \u0394FosB may epigenetically regulate gene expression and impair cognition across a wide range of epilepsy syndromes.<\/jats:p>","DOI":"10.3389\/fneur.2023.1331194","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:01:41Z","timestamp":1704949301000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hippocampal \u0394FosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies"],"prefix":"10.3389","volume":"14","author":[{"given":"Chia-Hsuan","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C.","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Mohila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Yoshor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela N.","family":"Viaene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","article-title":"Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies","volume":"88","author":"Fiest","year":"2017","journal-title":"Neurology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000503831","article-title":"The epidemiology of epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nrneurol.2011.3","article-title":"The neurobiology of cognitive disorders in temporal lobe epilepsy","volume":"7","author":"Bell","year":"2011","journal-title":"Nat Rev Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1684\/epd.2015.0739","article-title":"Cognitive impairment in epilepsy: the role of network abnormalities","volume":"17","author":"Holmes","year":"2015","journal-title":"Epileptic Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10267","DOI":"10.3390\/jcm11010267","article-title":"Cognitive impairment in people with epilepsy","volume":"11","author":"Novak","year":"2022","journal-title":"J Clin Med."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1093\/med\/9780199746545.003.0072","article-title":"Cognitive and behavioral co-morbidities of epilepsy","volume-title":"Jasper's Basic Mechanisms of the Epilepsies","author":"Kleen","year":"2012"},{"key":"B7","doi-asserted-by":"publisher","first-page":"a022772","DOI":"10.1101\/cshperspect.a022772","article-title":"Mechanisms responsible for cognitive impairment in epilepsy","volume":"5","author":"Lenck-Santini","year":"2015","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/ajmg.1320380274","article-title":"Seizure disorders in the fragile X chromosome syndrome","volume":"38","author":"Hecht","year":"1991","journal-title":"Am J Med Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature."},{"key":"B10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.braindev.2010.05.005","article-title":"Frequent association of autism spectrum disorder in patients with childhood onset epilepsy","volume":"32","author":"Matsuo","year":"2010","journal-title":"Brain Dev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3233\/JAD-2012-111613","article-title":"Down syndrome and dementia: seizures and cognitive decline","volume":"29","author":"Lott","year":"2012","journal-title":"J Alzheimers Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.yebeh.2012.11.040","article-title":"Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms","volume":"26","author":"Chin","year":"2013","journal-title":"Epilepsy Behav."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"J Am Med Assoc Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.yebeh.2014.12.022","article-title":"Clinical characteristics of children and young adults with co-occurring autism spectrum disorder and epilepsy","volume":"47","author":"El Achkar","year":"2015","journal-title":"Epilepsy Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"a022749","DOI":"10.1101\/cshperspect.a022749","article-title":"Epilepsy and autism","volume":"6","author":"Buckley","year":"2016","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer's disease: causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"107813","DOI":"10.1016\/j.yebeh.2021.107813","article-title":"Autism spectrum disorders and epilepsy in children: a commentary on the occurrence of autism in epilepsy; how it can present differently and the challenges associated with diagnosis","volume":"117","author":"Holmes","year":"2021","journal-title":"Epilepsy Behav."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1098\/rstb.2008.0067","article-title":"Review. Transcriptional mechanisms of addiction: role of DeltaFosB","volume":"363","author":"Nestler","year":"2008","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.celrep.2017.06.040","article-title":"DeltaFosB regulates gene expression and cognitive dysfunction in a mouse model of Alzheimer's disease","volume":"20","author":"Corbett","year":"2017","journal-title":"Cell Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3389\/fnins.2020.00472","article-title":"Genes bound by DeltaFosB in different conditions with recurrent seizures regulate similar neuronal functions","volume":"14","author":"Stephens","year":"2020","journal-title":"Front Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1021\/acschemneuro.1c00723","article-title":"DeltaFOSB: a potentially druggable master orchestrator of activity-dependent gene expression","volume":"13","author":"Robison","year":"2022","journal-title":"ACS Chem Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.molbrainres.2004.05.014","article-title":"DeltaFosB: a molecular switch for long-term adaptation in the brain","volume":"132","author":"Mcclung","year":"2004","journal-title":"Brain Res Mol Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0192508","DOI":"10.1371\/journal.pone.0192508","article-title":"Genome-wide profiling reveals functional diversification of \u0394FosB gene targets in the hippocampus of an Alzheimer's disease mouse model","volume":"13","author":"You","year":"2018","journal-title":"PLoS ONE."},{"key":"B24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.biopsych.2022.12.021","article-title":"Cell type-specific whole-genome landscape of DeltaFOSB binding in the nucleus accumbens after chronic cocaine exposure","volume":"94","author":"Yeh","year":"2023","journal-title":"Biol Psychiatry."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/nm.4413","article-title":"Epigenetic suppression of hippocampal calbindin-D28k by DeltaFosB drives seizure-related cognitive deficits","volume":"23","author":"You","year":"2017","journal-title":"Nat Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat Rev Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/WCO.0000000000000449","article-title":"Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis","volume":"30","author":"Spatola","year":"2017","journal-title":"Curr Opin Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/B978-0-12-802997-8.00016-5","article-title":"Epilepsy and brain tumors","volume":"134","author":"Englot","year":"2016","journal-title":"Handb Clin Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"10749","DOI":"10.3390\/ijms24010749","article-title":"The role of hyperexcitability in gliomagenesis","volume":"24","author":"Goethe","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/ana.26212","article-title":"Seizures after ischemic stroke: a matched multicenter study","volume":"90","author":"Ferreira-Atuesta","year":"2021","journal-title":"Ann Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s40266-021-00837-7","article-title":"Seizures and epilepsy after stroke: epidemiology, biomarkers and management","volume":"38","author":"Galovic","year":"2021","journal-title":"Drugs Aging."},{"key":"B32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1055\/s-0035-1552617","article-title":"Focal cortical dysplasia","volume":"35","author":"Crino","year":"2015","journal-title":"Semin Neurol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1080\/14737175.2021.1915135","article-title":"Focal cortical dysplasia: an update on diagnosis and treatment","volume":"21","author":"Guerrini","year":"2021","journal-title":"Expert Rev Neurother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pediatrneurol.2021.02.006","article-title":"Multicenter research data of epilepsy management in patients with Sturge-Weber syndrome","volume":"119","author":"Smegal","year":"2021","journal-title":"Pediatr Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/TACG.S363685","article-title":"Sturge-Weber syndrome: a review of pathophysiology, genetics, clinical features, and current management approach","volume":"16","author":"Sanchez-Espino","year":"2023","journal-title":"Appl Clin Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1177\/0883073810384869","article-title":"Risk and correlates of autism spectrum disorder in children with epilepsy: a community-based study","volume":"26","author":"Berg","year":"2011","journal-title":"J Child Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1007\/s10803-012-1675-9","article-title":"Epilepsy in individuals with a history of Asperger's syndrome: a Danish nationwide register-based cohort study","volume":"43","author":"Mouridsen","year":"2013","journal-title":"J Autism Dev Disord."},{"key":"B38","doi-asserted-by":"publisher","first-page":"65270","DOI":"10.3390\/ijms24065270","article-title":"Epilepsy and attention deficit hyperactivity disorder: connection, chance, and challenges","volume":"24","author":"Fan","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1021605","DOI":"10.3389\/fnhum.2023.1021605","article-title":"Epilepsy and attention-deficit\/hyperactivity disorder in children and adolescents: an overview of etiology, prevalence, and treatment","volume":"17","author":"Uliel-Sibony","year":"2023","journal-title":"Front Hum Neurosci."},{"key":"B40","volume-title":"WISC-IV: Wechsler Intelligence Scale for Children","author":"Wechsler","year":"2003"},{"key":"B41","volume-title":"WISC-IV: Advanced Clinical Interpretation","author":"Weiss","year":"2006"},{"key":"B42","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1111\/dmcn.12210","article-title":"Is the WISC-IV General Ability Index a useful tool for identifying intellectual disability?","volume":"55","author":"Lanfranchi","year":"2013","journal-title":"Dev Med Child Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/j.1469-8749.2006.tb01231.x","article-title":"Developmental dissociation, deviance, and delay: occurrence of attention-deficit-hyperactivity disorder in individuals with and without borderline-to-mild intellectual disability","volume":"48","author":"Voigt","year":"2006","journal-title":"Dev Med Child Neurol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.21307\/sjcapp-2021-007","article-title":"A longitudinal investigation of cognitive functioning and its relationship to symptom severity and academic functioning in treatment seeking youth with AHDH","volume":"9","author":"Tallberg","year":"2021","journal-title":"Scand J Child Adolesc Psychiatr Psychol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/j.1528-1167.2006.00554.x","article-title":"Incidence and predictors of seizures in patients with Alzheimer's disease","volume":"47","author":"Amatniek","year":"2006","journal-title":"Epilepsia."},{"key":"B46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12017-009-8076-z","article-title":"Epileptic seizures in AD patients","volume":"12","author":"Larner","year":"2010","journal-title":"Neuromolecular Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1002\/ana.24794","article-title":"Incidence and impact of subclinical epileptiform activity in Alzheimer's disease","volume":"80","author":"Vossel","year":"2016","journal-title":"Ann Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1007\/s00415-020-09937-7","article-title":"Seizures in Alzheimer's disease are highly recurrent and associated with a poor disease course","volume":"267","author":"Voglein","year":"2020","journal-title":"J Neurol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3233\/JAD-150096","article-title":"Epileptic prodromal Alzheimer's disease, a retrospective study of 13 new cases: expanding the spectrum of Alzheimer's disease to an epileptic variant?","volume":"52","author":"Cretin","year":"2016","journal-title":"J Alzheimer's Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/B978-0-444-64148-9.00006-5","article-title":"Borderline intellectual functioning","volume":"174","author":"Fernell","year":"2020","journal-title":"Handb Clin Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00127-009-0100-y","article-title":"The mental health of young children with intellectual disabilities or borderline intellectual functioning","volume":"45","author":"Emerson","year":"2010","journal-title":"Soc Psychiatry Psychiatr Epidemiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/13668250.2011.572548","article-title":"Comorbidity of intellectual disability and mental disorder in children and adolescents: a systematic review","volume":"36","author":"Einfeld","year":"2011","journal-title":"J Intellect Dev Disabil."},{"key":"B53","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40359-020-0372-2","article-title":"Is there an association between full IQ score and mental health problems in young adults? A study with a convenience sample","volume":"8","author":"Melby","year":"2020","journal-title":"BMC Psychol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"121847","DOI":"10.3390\/children9121847","article-title":"Challenges and neuropsychological functioning in children and adolescents with borderline intellectual functioning","volume":"9","author":"Satila","year":"2022","journal-title":"Children."},{"key":"B55","doi-asserted-by":"publisher","first-page":"13773","DOI":"10.1523\/JNEUROSCI.2083-15.2015","article-title":"Experience-dependent induction of hippocampal DeltaFosB controls learning","volume":"35","author":"Eagle","year":"2015","journal-title":"J Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"8360","DOI":"10.1021\/bi700494v","article-title":"Dimerization and DNA-binding properties of the transcription factor DeltaFosB","volume":"46","author":"Jorissen","year":"2007","journal-title":"Biochemistry."},{"key":"B57","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.jecp.2008.05.005","article-title":"Working memory in children: a time-constrained functioning similar to adults","volume":"102","author":"Portrat","year":"2009","journal-title":"J Exp Child Psychol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1177\/0963721412459513","article-title":"As time goes by:temporal constraints in working memory","volume":"21","author":"Barrouillet","year":"2012","journal-title":"Curr Dir Psychol Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1177\/08830738040190010201","article-title":"Mechanisms of action for the commonly used antiepileptic drugs: relevance to antiepileptic drug-associated neurobehavioral adverse effects","volume":"19","author":"Sankar","year":"2004","journal-title":"J Child Neurol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1528-1167.2006.00684.x","article-title":"Effects of antiepileptic drugs on mood and behavior","volume":"47","author":"Schmitz","year":"2006","journal-title":"Epilepsia."},{"key":"B61","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.yebeh.2012.09.018","article-title":"Antiepileptic drug effects on mood and behavior: molecular targets","volume":"26","author":"Perucca","year":"2013","journal-title":"Epilepsy Behav."},{"key":"B62","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.yebeh.2012.09.015","article-title":"Monitoring the cognitive effects of antiepileptic pharmacotherapy\u2013approaching the individual patient","volume":"26","author":"Witt","year":"2013","journal-title":"Epilepsy Behav."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1016\/j.celrep.2019.05.101","article-title":"Early seizure activity accelerates depletion of hippocampal neural stem cells and impairs spatial discrimination in an Alzheimer's disease model","volume":"27","author":"Fu","year":"2019","journal-title":"Cell Rep."},{"key":"B64","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/CCO.0000000000000581","article-title":"Treatment of cognitive deficits in brain tumour patients: current status and future directions","volume":"31","author":"Coomans","year":"2019","journal-title":"Curr Opin Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.3233\/JAD-170057","article-title":"Cognitive deficits after cerebral ischemia and underlying dysfunctional plasticity: potential targets for recovery of cognition","volume":"60","author":"Stradecki-Cohan","year":"2017","journal-title":"J Alzheimer's Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"878991","DOI":"10.3389\/fneur.2022.878991","article-title":"Mechanisms for cognitive impairment in epilepsy: moving beyond seizures","volume":"13","author":"Khalife","year":"2022","journal-title":"Front Neurol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1331194\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:01:45Z","timestamp":1704949305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1331194\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":66,"alternative-id":["10.3389\/fneur.2023.1331194"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2023.1331194","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]},"article-number":"1331194"}}