{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:58:37Z","timestamp":1784786317534,"version":"3.55.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>This study presents a case report of a male adolescent diagnosed with familial hemiplegic migraine type 2 (FHM2), an autosomal dominant inheritance disorder caused by ATP1A2 mutation. We report the patient who presented with headache, aphasia, and left-sided weakness. Cerebrovascular disease and various infectious agents were unremarkable during the patient\u2019s extended hospital stay. Our case revealed that brain hyperperfusion in familial hemiplegic migraine (FHM) persists over an extended duration, and despite the disease being in a state of recovery, enhanced brain magnetic resonance imaging (MRI) continues to exhibit hyperperfusion. A genetic testing was performed which revealed a mutation in the FHM2 gene (c.1133C\u2009&amp;gt;\u2009T). The patient has been followed for 3\u2009years after hospital discharge. The boy suffered four episodes of hemiplegia and multiple episodes of headaches, and gradually developed seizures and cognitive impairment. It is advisable to consider FHM as a potential diagnosis for patients presenting with typical symptoms such as recurrent paroxysmal headaches and limb activity disorders.<\/jats:p>","DOI":"10.3389\/fneur.2024.1339642","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T04:36:03Z","timestamp":1707194163000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Familial hemiplegic migraine type 2: a case report of an adolescent with ATP1A2 mutation"],"prefix":"10.3389","volume":"15","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1001\/jama.2009.932","article-title":"Migraine headache in middle age and late-life brain infarcts","volume":"301","author":"Scher","year":"2009","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"800605","DOI":"10.3389\/fneur.2021.800605","article-title":"Migraine: a review on its history, global epidemiology, risk factors, and comorbidities","volume":"12","author":"Amiri","year":"2022","journal-title":"Front Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"eaaz1584","DOI":"10.1126\/sciadv.aaz1584","article-title":"Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine","volume":"6","author":"Romanos","year":"2020","journal-title":"Sci Adv"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The international classification of headache disorders: 3rd edition","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0092-8674(00)81373-2","article-title":"Familial hemiplegic migraine and episodic ataxia Type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4","volume":"87","author":"Ophoff","year":"1996","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/ng1081","article-title":"Haploinsufficiency of ATP1A2 encoding the na+\/K+ pump \u03b12 subunit associated with familial hemiplegic migraine type 2","volume":"33","author":"Fusco","year":"2003","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0140-6736(05)66786-4","article-title":"Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine","volume":"366","author":"Dichgans","year":"2005","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19915-2","article-title":"Astrocyte deletion of \u03b12-na\/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway","volume":"11","author":"Smith","year":"2020","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1002\/glia.23194","article-title":"The \u03b12\u03b22 isoform combination dominates the astrocytic na+\/K+-ATPase activity and is rendered nonfunctional by the \u03b12.G301R familial hemiplegic migraine type 2-associated mutation","volume":"65","author":"Stoica","year":"2017","journal-title":"Glia"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e1002129","DOI":"10.1371\/journal.pgen.1002129","article-title":"Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2","volume":"7","author":"Leo","year":"2011","journal-title":"PLoS Genet"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"967","DOI":"10.15252\/emmm.201505944","article-title":"Defective glutamate and K+clearance by cortical astrocytes in familial hemiplegic migraine type 2","volume":"8","author":"Capuani","year":"2016","journal-title":"EMBO Mol Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1177\/0333102417738249","article-title":"Enhanced susceptibility to cortical spreading depression in two types of na+,K+-ATPase \u03b12 subunit-deficient mice as a model of familial hemiplegic migraine 2","volume":"38","author":"Unekawa","year":"2017","journal-title":"Cephalalgia"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1177\/0333102416651284","article-title":"Recurrent coma and fever in familial hemiplegic migraine type 2. 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