{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:25:12Z","timestamp":1787063112506,"version":"build-2736575974"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R21DC018101"],"award-info":[{"award-number":["R21DC018101"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Meniere\u2019s disease (MD) is defined by episodic vertigo, unilateral sensorineural hearing loss and fluctuating aural symptoms. Due to the variable clinical presentation, objective tests of MD may have significant diagnostic utility. Head kinematics derived from a head-mounted display (HMD) have demonstrated to be sensitive to vestibular dysfunction. The purpose of this pilot study was to investigate whether head sway can differentiate between patients with MD, vestibular hypofunction (VH) and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials\/methods<\/jats:title>\n                    <jats:p>80 adults (30 healthy controls, 32 with VH, and 18 with MD) were recruited from a tertiary vestibular clinic. All underwent a postural control assessment using the HTC Vive Pro Eye HMD that recorded head sway in the anterior\u2013posterior (AP), medio-lateral (ML), pitch, yaw and roll direction. Participants were tested with 2 levels of visual load: a static versus oscillating star display. Each scene lasted 60\u2009s and was repeated twice. Sway in each direction was quantified using root mean square velocity (VRMS) for the first 20\u2009s and full 60\u2009s of each scene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Static visual: participants with VH showed significantly larger head VRMS than controls in the AP (60\u2009s and 20\u2009s) and pitch (20\u2009s) directions. Dynamic visual: participants with VH showed significantly larger head VRMS than controls all directions for both the 60 and 20\u2009s analysis. Participants with MD did not differ significantly from the control or the VH group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While limited in numbers, Patients with MD had a high variability in head sway in all directions, and their average head sway was between controls and those with VH. A larger sample as well as patients with worse symptoms at time of testing could elucidate whether head sway via HMD could become a viable test in this population. A similar finding between 20- and 60-s scene and the full portability of the system with an in-clinic testing setup could help these future endeavors. Head sway derived from HMD is sensitive to VH and can be clinically useful as an outcome measure to evaluate sensory integration for postural control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2024.1347335","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:36:10Z","timestamp":1709166970000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Can head sway patterns differentiate between patients with Meniere\u2019s disease vs. peripheral vestibular hypofunction?"],"prefix":"10.3389","volume":"15","author":[{"given":"Jennifer L.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Cosetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat V.","family":"Lubetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00e8re\u2019s disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J Vestib Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015171.pub2","article-title":"Systemic pharmacological interventions for M\u00e9ni\u00e8re\u2019s disease","volume":"2023","author":"Webster","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599820909438","article-title":"Clinical Practice Guideline: M\u00e9ni\u00e8re\u2019s Disease","volume":"162","author":"Basura","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1001\/jamaoto.2022.0331","article-title":"Association between Meniere disease and migraine","volume":"148","author":"Kim","year":"2022","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e489","DOI":"10.1097\/MAO.0000000000003479","article-title":"A portrait of Meni\u00e8re\u2019s disease using contemporary hearing and balance tests","volume":"43","author":"Hannigan","year":"2022","journal-title":"Otol Neurotol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/NPT.0000000000000382","article-title":"Vestibular rehabilitation for peripheral vestibular hypofunction: an updated clinical practice guideline from the academy of neurologic physical therapy of the American Physical Therapy Association","volume":"46","author":"Hall","year":"2022","journal-title":"J Neurol Phys Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3389\/fneur.2018.01076","article-title":"Prevalence, determinants, and consequences of vestibular hypofunction. 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