{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:54:14Z","timestamp":1780419254014,"version":"3.54.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore the prevalence and risk factors of early postoperative seizures in patients with glioma through meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2013control studies and cohort studies on the prevalence and risk factors of early postoperative seizures in glioma patients were retrieved from various databases including CNKI, Wanfang, VIP, PubMed, Embase, Cochrane Library, and Web of Science, and the retrieval deadline for the data was 1 April 2023. Stata15.0 was used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review included 11 studies consisting of 488 patients with early postoperative seizures and 2,051 patients without early postoperative seizures. The research findings suggest that the prevalence of glioma is complicated by seizures (ES = 19%, 95% confidence interval [CI] [14%\u221225%]). The results also indicated a history of seizures (RR = 1.94, 95% CI [1.76, 2.14], <jats:italic>P<\/jats:italic> = 0.001), preoperative dyskinesia (RR = 3.13, 95% CI [1.20, 8.15], <jats:italic>P<\/jats:italic> = 0.02), frontal lobe tumor (RR = 1.45, 95% CI [1.16, 1.83], <jats:italic>P<\/jats:italic> = 0.001), pathological grade \u22642 (RR = 1.74, 95% CI [1.13, 2.67], <jats:italic>P<\/jats:italic> = 0.012), tumor\u2265 3 cm (RR = 1.70, 95% CI [1.18, 2.45], <jats:italic>P<\/jats:italic> = 0.005), tumor resection (RR = 1.60, 95% CI [1.36, 1.88], <jats:italic>P<\/jats:italic> = 0.001), tumor edema \u2265 2 cm (RR = 1.77, 95% CI [1.40, 2.25], <jats:italic>P<\/jats:italic> = 0.001), and glioma cavity hemorrhage (RR=3.15, 95% CI [1.85, 5.37], <jats:italic>P<\/jats:italic> = 0.001). The multivariate analysis results showed that a history of seizures, dyskinesia, tumor \u22653 cm, peritumoral edema \u22652 cm, and glioma cavity hemorrhage were indicated as risk factors for glioma complicated with early postoperative seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Based on the existing evidence, seizure history, dyskinesia, frontal lobe tumor, pathological grade \u22642, tumor \u22653 cm, partial tumor resection, edema around tumor \u22652 cm, and glioma cavity hemorrhage are indicated as risk factors for glioma complicated with early postoperative seizures.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1356715","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:39:52Z","timestamp":1710941992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and risk factors of early postoperative seizures in patients with glioma: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Bo","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13046-020-01778-6","article-title":"Clinical implication of cellular vaccine in glioma: current advances and future prospects","volume":"39","author":"Yan","year":"2020","journal-title":"J Exp Clin Cancer Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"107922","DOI":"10.1016\/j.pharmthera.2021.107922","article-title":"Genotoxic therapy and resistance mechanism in gliomas","volume":"228","author":"Lang","year":"2021","journal-title":"Pharmacol Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12943-022-01513-z","article-title":"Glioma targeted therapy: insight into future of molecular approaches","volume":"21","author":"Yang","year":"2022","journal-title":"Mol Cancer."},{"key":"B4","doi-asserted-by":"publisher","first-page":"104753","DOI":"10.1016\/j.phrs.2020.104753","article-title":"Gold nanoparticles in glioma theranostics","volume":"156","author":"Norouzi","year":"2020","journal-title":"Pharmacol Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.1002\/cncr.32884","article-title":"Survival among patients with glioma in the US military health system: a comparison with patients in the Surveillance, Epidemiology, and End Results program","volume":"126","author":"Lin","year":"2020","journal-title":"Cancer."},{"key":"B6","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/neuros\/nyz298","article-title":"High prevalence of developmental venous anomaly in diffuse intrinsic pontine gliomas: a pediatric control study","volume":"86","author":"Roux","year":"2020","journal-title":"Neurosurgery."},{"key":"B7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13293-021-00372-5","article-title":"Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones","volume":"12","author":"Bello-Alvarez","year":"2021","journal-title":"Biol Sex Differ."},{"key":"B8","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s10654-009-9355-6","article-title":"History of allergic disease and seizures and risk of glioma and meningioma (INTERPHONE study group, Germany)","volume":"24","author":"Berg-Beckhoff","year":"2009","journal-title":"Eur J Epidemiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neuroimage.2013.02.067","article-title":"Local MEG networks: the missing link between protein expression and seizures in glioma patients?","volume":"75","author":"Douw","year":"2013","journal-title":"Neuroimage."},{"key":"B10","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/neuonc\/nov269","article-title":"Seizures in glioma patients: mechanisms, management, and impact of anticonvulsant therapy","volume":"18","author":"Armstrong","year":"2016","journal-title":"Neuro Oncol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00018-019-03269-0","article-title":"Insights into the mechanisms of seizures from structural biology of LGI1-ADAM22","volume":"77","author":"Yamagata","year":"2020","journal-title":"Cell Mol Life Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s10654-022-00843-y","article-title":"Association of allergic diseases and seizures with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case-control study","volume":"37","author":"Schlehofer","year":"2022","journal-title":"Eur J Epidemiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/cns.14109","article-title":"Altering patterns of sensorimotor network in patients with different pathological diagnoses and glioma-related seizures under the latest glioma classification of the central nervous system","volume":"29","author":"Fang","year":"2023","journal-title":"CNS Neurosci Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/neuonc\/now190","article-title":"Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials","volume":"19","author":"Avila","year":"2017","journal-title":"Neuro Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e2185","DOI":"10.1212\/WNL.0000000000007475","article-title":"Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABA(B) R encephalitis","volume":"92","author":"de Bruijn","year":"2019","journal-title":"Neurology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/epi.16880","article-title":"First-line antiepileptic drug treatment in glioma patients with seizures: levetiracetam vs valproic acid","volume":"62","author":"van der Meer","year":"2021","journal-title":"Epilepsia."},{"key":"B17","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1136\/jnnp-2021-326968","article-title":"Postoperative de novo seizures after craniotomy: a nationwide register-based cohort study","volume":"93","author":"Giraldi","year":"2022","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/14737175.2016.1219250","article-title":"The withdrawal of antiepileptic drugs in patients with low-grade and anaplastic glioma","volume":"17","author":"Koekkoek","year":"2017","journal-title":"Expert Rev Neurother."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.canlet.2020.10.050","article-title":"Clinical practice guidelines for the management of adult diffuse gliomas","volume":"499","author":"Jiang","year":"2021","journal-title":"Cancer Lett."},{"key":"B21","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol."},{"key":"B22","first-page":"204","article-title":"Risk factors for early epileptic seizures after brain glioma surgery","volume":"24","author":"Dong","year":"2019","journal-title":"Chin J Microinv Neurosurg"},{"key":"B23","first-page":"97","article-title":"Risk factors for early postoperative seizures in patients with glioma","volume":"35","author":"Deng","year":"2022","journal-title":"Med Equip."},{"key":"B24","first-page":"287","article-title":"Risk factors of early epileptic seizure after supratentorial glioma surgery","volume":"25","author":"Gui","year":"2012","journal-title":"J Stereot Funct Neurosurg"},{"key":"B25","first-page":"947","article-title":"Analysis of the status quo and risk factors of seizures in early stage after brain glioma surgery","volume":"15","author":"Hasmujiang","year":"2017","journal-title":"Cancer Prog"},{"key":"B26","first-page":"471","article-title":"Analysis of influencing factors of seizures after brain glioma surgery","volume":"4","author":"Hu","year":"2014","journal-title":"Shaanxi Med J"},{"key":"B27","first-page":"1337","article-title":"Analysis of related influencing factors of epileptic seizure after craniocerebral glioma surgery","volume":"57","author":"Tian","year":"2022","journal-title":"China Med J"},{"key":"B28","first-page":"24","article-title":"Analysis of risk factors for early epileptic seizure after brain glioma surgery","volume":"24","author":"Yang","year":"2015","journal-title":"Chin J Appl Neurol Dis"},{"key":"B29","first-page":"68","article-title":"Analysis of related factors of early epileptic seizure after brain glioma surgery","volume":"7","author":"Zhang","year":"2014","journal-title":"Chin J Appl Neurol Dis"},{"key":"B30","first-page":"138","article-title":"Logistic regression analysis of risk factors associated with early epileptic seizure after brain glioma surgery","volume":"34","author":"Zhang","year":"2021","journal-title":"Cancer Prev Treatment"},{"key":"B31","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1212\/WNL.0b013e318266fa89","article-title":"Glutamate is associated with a higher risk of seizures in patients with gliomas","volume":"79","author":"Yuen","year":"2012","journal-title":"Neurology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e947","DOI":"10.1016\/j.wneu.2019.01.213","article-title":"The analysis of risk factors and survival outcome for Chinese patients with seizures with high-grade glioma","volume":"125","author":"Yu","year":"2019","journal-title":"World Neurosurg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1055\/s-0040-1718719","article-title":"Seizures-definition, classification, pathophysiology, and epidemiology","volume":"40","author":"Falco-Walter","year":"2020","journal-title":"Semin Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1111\/epi.17241","article-title":"International league against seizures classification and definition of seizures syndromes with onset in childhood: position paper by the ilae task force on nosology and definitions","volume":"63","author":"Specchio","year":"2022","journal-title":"Epilepsia."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s12098-020-03510-w","article-title":"Metabolic seizures","volume":"88","author":"Reddy","year":"2021","journal-title":"Indian J Pediatr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"w13155","DOI":"10.4414\/smw.2011.13155","article-title":"Risk factors for a first epileptic seizure symptomatic of brain tumour or brain vascular malformation. A case control study","volume":"141","author":"Leone","year":"2011","journal-title":"Swiss Med Wkly."},{"key":"B37","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s11060-020-03520-w","article-title":"Awake craniotomy for gliomas involving motor-related areas: classification and function recovery","volume":"148","author":"Fang","year":"2020","journal-title":"J Neurooncol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"725926","DOI":"10.3389\/fonc.2021.725926","article-title":"Radiomics for the prediction of seizures in patients with frontal glioma","volume":"11","author":"Gao","year":"2021","journal-title":"Front Oncol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11060-022-04139-9","article-title":"Diffusion tensor imaging changes in patients with glioma-associated seizures","volume":"160","author":"Mader","year":"2022","journal-title":"J Neurooncol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"499","DOI":"10.25259\/SNI_791_2021","article-title":"Pediatric angiocentric glioma with acute intracerebral hemorrhage: a case report with 36 months follow-up","volume":"12","author":"Zhang","year":"2021","journal-title":"Surg Neurol Int."},{"key":"B41","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1046\/j.1528-1157.2003.56102.x","article-title":"The spectrum of long-term seizures-associated tumors: long-term seizure and tumor outcome and neurosurgical aspects","volume":"44","author":"Luyken","year":"2003","journal-title":"Epilepsia."},{"key":"B42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40478-020-00904-x","article-title":"Low-grade developmental and seizures associated brain tumors: a critical update 2020","volume":"8","author":"Slegers","year":"2020","journal-title":"Acta Neuropathol Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e12769","DOI":"10.1111\/nan.12769","article-title":"Low-grade seizures-associated neuroepithelial tumours with a prominent oligodendroglioma-like component: the diagnostic challenges","volume":"48","author":"M\u00e9tais","year":"2022","journal-title":"Neuropathol Appl Neurobiol."},{"key":"B44","first-page":"5","article-title":"Early postoperative seizures in patients undergoing craniotomy for glioblastoma multiforme","volume":"20","author":"Telfeian","year":"2001","journal-title":"J Exp Clin Cancer Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.5114\/fn.2014.45566","article-title":"Angiocentric glioma: a rare intractable seizures-related tumour in children","volume":"52","author":"Grajkowska","year":"2014","journal-title":"Folia Neuropathol."}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1356715\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:40:04Z","timestamp":1710942004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1356715\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,20]]},"references-count":45,"alternative-id":["10.3389\/fneur.2024.1356715"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1356715","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,20]]},"article-number":"1356715"}}