{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:29:05Z","timestamp":1789000145130,"version":"build-2803163510"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K09856"],"award-info":[{"award-number":["19K09856"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study habituation disorders in auditory middle latency response (AMLR) to repetitive stimuli of persistent postural-perceptual dizziness (PPPD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Twenty-eight PPPD (10 men and 18 women, mean 59.5\u2009years of age, 26\u201381\u2009years of age) were enrolled. For comparison, data of 13 definite vestibular migraine (VM) patients (3 men, 10 women, mean age 45.5), 13 definite unilateral Meniere\u2019s disease (MD) patients (2 men, 11 women, mean age 50.6), and 8 healthy control (HC) subjects (2 men, 6 women, mean age 37.1) in the previous study were utilized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The electrodes were placed on the vertex and the spinal process of the fifth cervical vertebra. Clicks (0.1\u2009msec, 70\u2009dB nHL) were binaurally presented and averaged (800 times). Averaged responses were divided into 4 sets (S1 to S4) according to the temporal order. As peaks, Na, and Pa were identified, and relative Na-Pa amplitudes in S2\u2013S4 to S1 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean relative amplitude of PPPD patients showed lack of habituation (potentiation) as shown in VM patients, although the extent of potentiation was weaker than VM. Comparison of relative S4 amplitudes showed significant differences among the 4 groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.0013 one-way ANOVA), Multiple comparison revealed significant differences between PPPD and MD (<jats:italic>p<\/jats:italic>\u2009=\u20090.0337 Dunnet\u2019s test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PPPD patients showed lack of habituation (potentiation) of Na-Pa amplitude in AMLR to repetitive stimuli. Lack of habituation (potentiation) might be associated with sensory processing disorders in PPPD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1366420","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T04:57:01Z","timestamp":1709701021000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Habituation disorders in auditory middle latency response of persistent postural-perceptual dizziness patients"],"prefix":"10.3389","volume":"15","author":[{"given":"Toshihisa","family":"Murofushi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyuki","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munetaka","family":"Ushio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3233\/VES-170622","article-title":"Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): consensus document of the committee for the classification of vestibular disorders of the Barany Society","volume":"27","author":"Staab","year":"2017","journal-title":"J Vestib Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"4274","DOI":"10.3390\/jcm10184274","article-title":"Brain correlates of persistent postural perceptual dizziness: a review of neuroimaging studies","volume":"10","author":"Indovina","year":"2021","journal-title":"J Clin Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"795516","DOI":"10.3389\/fneur.2021.795516","article-title":"Persistent postural-perceptual dizziness: precipitating condition\u2019s, co-morbidities and treatment with cognitive behavioral therapy","volume":"12","author":"Waterston","year":"2021","journal-title":"Front Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/brain\/121.2.233","article-title":"Visual evoked potentials during long periods of pattern-reversed stimulation in migraine","volume":"121","author":"Afra","year":"1998","journal-title":"Brain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1093\/brain\/awg206","article-title":"Lack of habituation causes high intensity dependence of auditory cortical potentials in migraine","volume":"126","author":"Ambrosini","year":"2003","journal-title":"Brain"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fneur.2020.00024","article-title":"Vestibular migraine patients show lack of habituation in auditory middle latency responses to repetitive stimuli: comparison with Meniere\u2019s disease patients","volume":"11","author":"Murofushi","year":"2020","journal-title":"Front Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-4612-2838-7_6","article-title":"Electrophysiology of the human auditory system","volume-title":"The mammalian auditory pathway: neurophysiology","author":"Kraus","year":"1992"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0013-4694(74)90155-2","article-title":"Human auditory evoked potentials. 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