{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:15:09Z","timestamp":1793121309324,"version":"4.5.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare the clinical outcomes of spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRG-S) in the treatment of painful diabetic peripheral neuropathy (PDPN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, 55 patients received dorsal column spinal cord stimulation (SCS group) and 51 patients received dorsal root spinal cord stimulation (DRG-S group). The primary outcome was a Numerical Rating Scale (NRS) remission rate of \u226550%, and secondary outcomes included the effects of SCS and DRG-S on quality of life scores (EQ-5D-3L), nerve conduction velocity, and HbA1c, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of NRS remission rate \u2265\u200950% at 6\u2009months was 80.43 vs. 79.55%, OR (95% CI): 1.06 (0.38\u20132.97) in the SCS and DRG-S groups, respectively, and the percentage of VAS remission rate \u2265\u200950% at 12\u2009months was 79.07 vs. 80.95%, OR (95% CI): 0.89 (0.31\u20132.58). Compared with baseline, there were significant improvements in EQ-5D and EQ-VAS at 6 and 12\u2009months (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05), but there was no difference in improvement between the SCS and DRG-S groups (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). Nerve conduction velocities of the common peroneal, peroneal, superficial peroneal, and tibial nerves were significantly improved at 6 and 12\u2009months compared with the preoperative period in both the SCS and PND groups (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.05). However, at 6 and 12\u2009months, there was no difference in HbA1c between the two groups (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both SCS and DRG-S significantly improved pain, quality of life, and lower extremity nerve conduction velocity in patients with PDPN, and there was no difference between the two treatments at 12\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1366796","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T04:35:17Z","timestamp":1712723717000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of the efficacy of spinal cord stimulation and dorsal root ganglion stimulation in the treatment of painful diabetic peripheral neuropathy: a prospective, cohort-controlled study"],"prefix":"10.3389","volume":"15","author":[{"given":"Yu-Fei","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s11892-019-1150-5","article-title":"Painful and painless diabetic neuropathies: what is the difference?","volume":"19","author":"Shillo","year":"2019","journal-title":"Curr Diab 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