{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:55:15Z","timestamp":1757451315935,"version":"3.41.2"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>According to observational research, migraine may increase the risk of Meniere\u2019s disease (MD). The two have not, however, been proven to be causally related.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using Mendelian random (MR) analysis, we aimed to evaluate any potential causal relationship between migraine and MD. We extracted single-nucleotide polymorphisms (SNPs) from large-scale genome-wide association studies (GWAS) involving European individuals, focusing on migraine and MD. The main technique used to evaluate effect estimates was inverse-variance weighting (IVW). To assess heterogeneity and pleiotropy, sensitivity analyses were carried out using weighted median, MR-Egger, simple mode, weighted mode, and MR-PRESSO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no discernible causative link between genetic vulnerability to MD and migraine. The migraine dose not increase the prevalence of MD in the random-effects IVW method (OR = 0.551, <jats:italic>P<\/jats:italic> = 0.825). The extra weighted median analysis (OR = 0.674, <jats:italic>P<\/jats:italic> = 0.909), MR-Egger (OR = 0.068, <jats:italic>P<\/jats:italic> = 0.806), Simple mode (OR = 0.170, <jats:italic>P<\/jats:italic> = 0.737), and Weighted mode (OR = 0.219, <jats:italic>P<\/jats:italic>= 0.760) all showed largely consistent results. The MD dose not increase the prevalence of migraine in the random-effects IVW method (OR = 0.999, <jats:italic>P<\/jats:italic> = 0.020). The extra weighted median analysis (OR = 0.999, <jats:italic>P<\/jats:italic> = 0.909), MR-Egger (OR = 0.999, <jats:italic>P<\/jats:italic> = 0.806), Simple mode (OR = 0.999, <jats:italic>P<\/jats:italic> = 0.737), and Weighted mode (OR = 1.000, <jats:italic>P<\/jats:italic> = 0.760).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and significance<\/jats:title><jats:p>This Mendelian randomization study provides casual evidence that migraine is not a risk factor for MD and MD is also not a risk factor for migraine.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1367428","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:58:11Z","timestamp":1715230691000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Mendelian randomization analysis does not reveal a causal association between migraine and Meniere\u2019s disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Kangjia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruosha","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.21053\/ceo.2021.00920","article-title":"Cytokines and Inflammation in Meniere Disease","volume":"15","author":"Frejo","year":"2023","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"ref2","article-title":"Epidemiology and genetics of Meniere\u2019s disease","author":"Lopez-Escamez","year":"2023","journal-title":"Curr Opin Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"10303","DOI":"10.1038\/s41598-023-36479-5","article-title":"Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere\u2019s disease","volume":"13","author":"B\u00e4chinger","year":"2003","journal-title":"Sci Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10162-023-00896-0","article-title":"Types of Inheritance and Genes Associated with Familial Meniere Disease","volume":"24","author":"Parra-Perez","year":"2023","journal-title":"J Assoc Res Otolaryngol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-021-02389-7","article-title":"A review of migraine genetics: gathering genomic and transcriptomic factors","volume":"141","author":"Dias","year":"2022","journal-title":"Hum Genet"},{"key":"ref6","article-title":"Development and Validation of the Predictive Model for the Differentiation between Vestibular Migraine and Meniere\u2019s Disease","volume":"11","author":"Liu","year":"2022","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meni\u00e8re\u2019s disease? 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