{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:14:26Z","timestamp":1790741666553,"version":"4.1.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Migraine is a prevalent and disabling neurovascular disorder, with women being more susceptible, characterized by unilateral throbbing headache, often accompanied by nausea and vomiting, and often associated with various comorbidities such as brain and cardiovascular diseases, which can have a serious impact on quality of life. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the main first-line medications for the treatment of pain, long-term use often leads to side effects and drug addiction, which emphasizes the need to investigate alternative pain management strategies with fewer adverse effects. Complementary and alternative medicine is a viable pain intervention often used in conjunction with traditional medications, including acupuncture, herbs, moxibustion, transcutaneous electrical stimulation, bio-supplements, and acupressure, which offer non-pharmacological alternatives that are now viable pain management options. This review focuses on the mechanistic doctrine of migraine generation and the role and potential mechanisms of Complementary and Alternative Therapies (CAT) in the treatment of migraine, summarizes the research evidences for CAT as an adjunct or alternative to conventional therapies for migraine, and focuses on the potential of novel migraine therapies (calcitonin gene-related peptide (CGRP) antagonists and pituitary adenylyl cyclase-activating peptide (PACAP) antagonists) with the aim of evaluating CAT therapies as adjunctive or alternative therapies to conventional migraine treatment, thereby providing a broader perspective on migraine management and the design of treatment programs for more effective pain management.<\/jats:p>","DOI":"10.3389\/fneur.2024.1372509","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:30:27Z","timestamp":1715229027000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies"],"prefix":"10.3389","volume":"15","author":[{"given":"Xiaoli","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqian","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41572-021-00328-4","article-title":"Migraine","volume":"8","author":"Ferrari","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/cells11081355","article-title":"Tassorelli C: role of estrogens in menstrual migraine","volume":"11","author":"Nappi","year":"2022","journal-title":"Cells"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1001\/jama.2021.1640","article-title":"Diagnosis and Management of Headache: a review","volume":"325","author":"Robbins","year":"2021","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s11916-011-0233-z","article-title":"Defining the differences between episodic migraine and chronic migraine","volume":"16","author":"Katsarava","year":"2012","journal-title":"Curr Pain Headache Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1177\/0333102411402367","article-title":"Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies","volume":"31","author":"Meng","year":"2011","journal-title":"Cephalalgia"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/head.13443","article-title":"Analysis of initial nonresponders to Galcanezumab in patients with episodic or chronic migraine: results from the EVOLVE-1, EVOLVE-2, and REGAIN randomized, double-blind, Placebo-Controlled Studies","volume":"59","author":"Nichols","year":"2019","journal-title":"Headache"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e067670","DOI":"10.1136\/bmj-2021-067670","article-title":"Management of chronic migraine","volume":"379","author":"Hovaguimian","year":"2022","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"033310242211437","DOI":"10.1177\/03331024221143773","article-title":"Place of next generation acute migraine specific treatments among triptans, non-responders and contraindications to triptans and possible combination therapies","volume":"43","author":"de Boer","year":"2023","journal-title":"Cephalalgia"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s40120-021-00234-7","article-title":"Ubrogepant for the acute treatment of migraine: pooled efficacy, safety, and tolerability from the ACHIEVE I and ACHIEVE II phase 3 randomized trials","volume":"10","author":"Hutchinson","year":"2021","journal-title":"Neurol Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/ejp.1374","article-title":"Non-pharmacological management of persistent headaches associated with neck pain: a clinical practice guideline from the Ontario protocol for traffic injury management (OPTIMa) collaboration","volume":"23","author":"C\u00f4t\u00e9","year":"2019","journal-title":"Eur J Pain"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1007\/s11606-019-05413-9","article-title":"Yoga for treating headaches: a systematic review and Meta-analysis","volume":"35","author":"Anheyer","year":"2020","journal-title":"J Gen Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"Cd011890","DOI":"10.1002\/14651858.CD011890.pub3","article-title":"Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane reviews","volume":"4","author":"Gibson","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/WNO.0000000000001053","article-title":"Acute care treatment of migraine","volume":"40","author":"Konstantinos","year":"2020","journal-title":"J Neuroophthalmol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e30926","DOI":"10.1097\/MD.0000000000030926","article-title":"Efficacy of scalp acupuncture for migraine: a protocol for systematic review and meta-analysis","volume":"101","author":"Kim","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1129-2377-14-80","article-title":"Peripheral vascular dysfunction in migraine: a review","volume":"14","author":"Sacco","year":"2013","journal-title":"J Headache Pain"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ejphar.2009.08.034","article-title":"Modulatory effects of probenecid on the nitroglycerin-induced changes in the rat caudal trigeminal nucleus","volume":"621","author":"Vamos","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1263535","DOI":"10.3389\/fneur.2023.1263535","article-title":"Breaking the cycle: unraveling the diagnostic, pathophysiological and treatment challenges of refractory migraine","volume":"14","author":"Robblee","year":"2023","journal-title":"Front Neurol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s10194-023-01643-9","article-title":"Mechanisms of initiation of cortical spreading depression","volume":"24","author":"Vitale","year":"2023","journal-title":"J Headache Pain"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/0333102420970507","article-title":"Combined onabotulinumtoxin a\/atogepant treatment blocks activation\/sensitization of high-threshold and wide-dynamic range neurons","volume":"41","author":"Melo-Carrillo","year":"2021","journal-title":"Cephalalgia"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s10194-023-01598-x","article-title":"Estrogen modulation of cortical spreading depression","volume":"24","author":"Kudo","year":"2023","journal-title":"J Headache Pain"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1111\/head.13935","article-title":"Migraine as a cortical brain disorder","volume":"60","author":"Barbanti","year":"2020","journal-title":"Headache"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1129-2377-14-62","article-title":"Cortical spreading depression as a target for anti-migraine agents","volume":"14","author":"Costa","year":"2013","journal-title":"J Headache Pain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"6001","DOI":"10.1523\/JNEUROSCI.0232-19.2019","article-title":"CSD-induced arterial dilatation and plasma protein extravasation are unaffected by Fremanezumab: implications for CGRP's role in migraine with Aura","volume":"39","author":"Schain","year":"2019","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"864689","DOI":"10.3389\/fneur.2022.864689","article-title":"Petasites for migraine prevention: new data on mode of action, pharmacology and safety. A narrative review","volume":"13","author":"Borlak","year":"2022","journal-title":"Front Neurol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1111\/bph.13917","article-title":"The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel","volume":"174","author":"Benemei","year":"2017","journal-title":"Br J Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s10194-023-01547-8","article-title":"Genetics of migraine: where are we now?","volume":"24","author":"Grangeon","year":"2023","journal-title":"J Headache Pain"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"105946","DOI":"10.1016\/j.nbd.2022.105946","article-title":"Role of PACAP in migraine: An alternative to CGRP?","volume":"176","author":"Guo","year":"2023","journal-title":"Neurobiol Dis"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1093\/brain\/awac040","article-title":"The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?","volume":"145","author":"Ernstsen","year":"2022","journal-title":"Brain"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1097\/j.pain.0000000000002147","article-title":"Increase in trigeminal ganglion neurons that respond to both calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in mouse models of chronic migraine and posttraumatic headache","volume":"162","author":"Guo","year":"2021","journal-title":"Pain"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/biomedicines10010076","article-title":"Neurogenic inflammation: the participant in migraine and recent advancements in translational research","volume":"10","author":"Spekker","year":"2021","journal-title":"Biomedicines"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s10194-020-01134-1","article-title":"The fifth cranial nerve in headaches","volume":"21","author":"Edvinsson","year":"2020","journal-title":"J Headache Pain"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s10194-019-1066-0","article-title":"Mechanisms of migraine as a chronic evolutive condition","volume":"20","author":"Andreou","year":"2019","journal-title":"J Headache Pain"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.exger.2015.09.017","article-title":"Age differences in cytokine expression under conditions of health using experimental pain models","volume":"72","author":"Cruz-Almeida","year":"2015","journal-title":"Exp Gerontol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.13703\/j.0255-2930.20190927-k0003","article-title":"Analgesic mechanism of acupuncture on neuropathic pain","volume":"40","author":"Wang","year":"2020","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"104949","DOI":"10.1016\/j.phrs.2020.104949","article-title":"Role of 5-HT receptors in neuropathic pain: potential therapeutic implications","volume":"159","author":"Liu","year":"2020","journal-title":"Pharmacol Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4062\/biomolther.2017.127","article-title":"Depolarizing effectors of bradykinin signaling in nociceptor excitation in pain perception","volume":"26","author":"Choi","year":"2018","journal-title":"Biomol Ther (Seoul)"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1093\/brain\/awz134","article-title":"Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine","volume":"142","author":"Goadsby","year":"2019","journal-title":"Brain"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"695670","DOI":"10.3389\/fnins.2021.695670","article-title":"Role of Neuroimmune crosstalk in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain","volume":"15","author":"Dou","year":"2021","journal-title":"Front Neurosci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"E153","DOI":"10.1503\/cmaj.211969","article-title":"Diagnosis and acute management of migraine","volume":"195","author":"Tzankova","year":"2023","journal-title":"CMAJ"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1097\/j.pain.0000000000002235","article-title":"Delta opioid receptor regulation of calcitonin gene-related peptide dynamics in the trigeminal complex","volume":"162","author":"Moye","year":"2021","journal-title":"Pain"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1152\/physrev.00059.2021","article-title":"CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond","volume":"103","author":"Russo","year":"2023","journal-title":"Physiol Rev"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1056\/NEJMra1915327","article-title":"Migraine","volume":"383","author":"Ashina","year":"2020","journal-title":"N Engl J Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fneur.2019.00199","article-title":"Pediatric vs. adult Prodrome and postdrome: a window on migraine pathophysiology?","volume":"10","author":"Cuvellier","year":"2019","journal-title":"Front Neurol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/medsci9040067","article-title":"Sodium chloride, migraine and salt withdrawal: controversy and insights","volume":"9","author":"Brown","year":"2021","journal-title":"Med Sci (Basel)"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41588-021-00990-0","article-title":"Genome-wide analysis of 102, 084 migraine cases identifies 123 risk loci and subtype-specific risk alleles","volume":"54","author":"Hautakangas","year":"2022","journal-title":"Nat Genet"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jad.2023.04.108","article-title":"Effects of eight weeks of aerobic exercise and vitamin D supplementation on psychiatric comorbidities in men with migraine and vitamin D insufficiency: a randomized controlled clinical trial","volume":"334","author":"Alipouri","year":"2023","journal-title":"J Affect Disord"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11916-019-0750-8","article-title":"Complementary and integrative medicine for episodic migraine: an update of evidence from the last 3 years","volume":"23","author":"Wells","year":"2019","journal-title":"Curr Pain Headache Rep"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"m697","DOI":"10.1136\/bmj.m697","article-title":"Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial","volume":"368","author":"Xu","year":"2020","journal-title":"BMJ"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s11684-023-0989-7","article-title":"Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics","volume":"17","author":"Li","year":"2023","journal-title":"Front Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.brs.2021.10.383","article-title":"Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation","volume":"14","author":"Leahu","year":"2021","journal-title":"Brain Stimul"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1177\/0333102419869319","article-title":"Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine","volume":"40","author":"Martins","year":"2020","journal-title":"Cephalalgia"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/head.14065","article-title":"Dietary magnesium and migraine in adults: a cross-sectional analysis of the National Health and nutrition examination survey 2001-2004","volume":"61","author":"Slavin","year":"2021","journal-title":"Headache"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.3390\/nu14051089","article-title":"Magnesium as an important factor in the pathogenesis and treatment of migraine-from theory to practice","volume":"14","author":"Domitrz","year":"2022","journal-title":"Nutrients"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s10194-021-01234-6","article-title":"Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial","volume":"22","author":"Khani","year":"2021","journal-title":"J Headache Pain"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1243231","DOI":"10.3389\/fnins.2023.1243231","article-title":"Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research","volume":"17","author":"Su","year":"2023","journal-title":"Front Neurosci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1186\/s10194-015-0516-6","article-title":"Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial","volume":"16","author":"Gaul","year":"2015","journal-title":"J Headache Pain"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.3390\/nu13082612","article-title":"Experimental and clinical evidence of the effectiveness of riboflavin on migraines","volume":"13","author":"Yamanaka","year":"2021","journal-title":"Nutrients"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1142\/S0192415X2050086X","article-title":"Progress in traditional Chinese medicine for the treatment of migraine","volume":"48","author":"Huang","year":"2020","journal-title":"Am J Chin Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12906-022-03536-x","article-title":"Artemisia argyi extract alleviates inflammation in a DSS-induced colitis mouse model and enhances immunomodulatory effects in lymphoid tissues","volume":"22","author":"Shin","year":"2022","journal-title":"BMC Complement Med Ther"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"865376","DOI":"10.3389\/fphar.2022.865376","article-title":"Antidepressant potential of quercetin and its glycoside derivatives: a comprehensive review and update","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"920201","DOI":"10.3389\/fphar.2022.920201","article-title":"Xiongshao Zhitong recipe attenuates nitroglycerin-induced migraine-like behaviors via the inhibition of inflammation mediated by nitric oxide synthase","volume":"13","author":"Yang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"758026","DOI":"10.3389\/fphar.2021.758026","article-title":"Emodin interferes with nitroglycerin-induced migraine in rats through CGMP-PKG pathway","volume":"12","author":"Sun","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13256-023-03915-z","article-title":"Managing acute phantom limb pain with transcutaneous electrical nerve stimulation: a case report","volume":"17","author":"Limakatso","year":"2023","journal-title":"J Med Case Rep"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2522\/ptj.20150267","article-title":"Therapeutic exercise training to reduce chronic headache in working women: Design of a Randomized Controlled Trial","volume":"96","author":"Rinne","year":"2016","journal-title":"Phys Ther"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"E733","DOI":"10.36076\/ppj.2021.24.E733","article-title":"A randomized controlled trial of high rate rTMS versus rTMS and amitriptyline in chronic migraine","volume":"24","author":"Kalita","year":"2021","journal-title":"Pain Physician"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.pain.2014.02.024","article-title":"Cyclical changes of cortical excitability and metaplasticity in migraine: evidence from a repetitive transcranial magnetic stimulation study","volume":"155","author":"Cosentino","year":"2014","journal-title":"Pain"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s40120-020-00216-1","article-title":"Acupuncture and its role in the treatment of migraine headaches","volume":"9","author":"Urits","year":"2020","journal-title":"Neurol Ther"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"Cd001218","DOI":"10.1002\/14651858.CD007587.pub2","article-title":"Acupuncture for the prevention of episodic migraine","volume":"2016","author":"Linde","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1001\/jamainternmed.2016.9378","article-title":"The long-term effect of acupuncture for migraine prophylaxis: a randomized clinical trial","volume":"177","author":"Zhao","year":"2017","journal-title":"JAMA Intern Med"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jbmt.2022.09.008","article-title":"An investigation of the effects of connective tissue massage in women with migraine: a controlled clinical trial","volume":"33","author":"Toprak Celenay","year":"2023","journal-title":"J Bodyw Mov Ther"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/S0254-6272(17)30047-X","article-title":"Effects of feet reflexology versus segmental massage in reducing pain and its intensity, frequency and duration of the attacks in females with migraine: a pilot study","volume":"37","author":"Wojciech","year":"2017","journal-title":"J Tradit Chin Med"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s10194-023-01587-0","article-title":"The temporal trend of placebo response in migraine prevention from 1990 to 2021: a systematic literature review and meta-analysis with regression","volume":"24","author":"Tepper","year":"2023","journal-title":"J Headache Pain"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12906-017-1694-3","article-title":"Subjective perceived impact of tai chi training on physical and mental health among community older adults at risk for ischemic stroke: a qualitative study","volume":"17","author":"Zheng","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"j1805","DOI":"10.1136\/bmj.j1805","article-title":"Bauer B: complementary and integrative medicine in the management of headache","volume":"357","author":"Millstine","year":"2017","journal-title":"BMJ"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ana.25697","article-title":"Longitudinal neuroimaging over 30\u2009days: temporal characteristics of migraine","volume":"87","author":"Schulte","year":"2020","journal-title":"Ann Neurol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1093\/brain\/awac105","article-title":"Elucidating the relationship between migraine risk and brain structure using genetic data","volume":"145","author":"Mitchell","year":"2022","journal-title":"Brain"},{"key":"ref77","first-page":"264","article-title":"A potential preclinical migraine model: CGRP-sensitized mice","volume":"1","author":"Russo","year":"2009","journal-title":"Mol Cell Pharmacol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1054333","DOI":"10.3389\/fneur.2022.1054333","article-title":"Variability in oxidative stress-related genes (SOD2, CAT, GPX1, GSTP1, NOS3, NFE2L2, and UCP2) and susceptibility to migraine clinical phenotypes and features","volume":"13","author":"Papasavva","year":"2023","journal-title":"Front Neurol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.3390\/jcm10194580","article-title":"Combined anticoagulation and Antiaggregation in acute cervical artery dissection","volume":"10","author":"von Gottberg","year":"2021","journal-title":"J Clin Med"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"6171","DOI":"10.3390\/molecules28166171","article-title":"LC-MS\/MS evaluation of pyrrolizidine alkaloids profile in relation to safety of comfrey roots and leaves from polish sources","volume":"28","author":"Kimel","year":"2023","journal-title":"Molecules"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1256415","DOI":"10.3389\/fnhum.2023.1256415","article-title":"A state-of-the-art review of functional magnetic resonance imaging technique integrated with advanced statistical modeling and machine learning for primary headache diagnosis","volume":"17","author":"Li","year":"2023","journal-title":"Front Hum Neurosci"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1372509\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:30:33Z","timestamp":1715229033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1372509\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":81,"alternative-id":["10.3389\/fneur.2024.1372509"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1372509","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"article-number":"1372509"}}