{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:50:55Z","timestamp":1794091855170,"version":"4.8.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sleep disturbances are common in migraine patients and affect quality of life. Central sensitization (CS) is likely to play a role in the increased severity and chronicity of migraine. We hypothesized that the number of comorbid sleep problems would affect headache-related disability through the effects of central sensitization (CS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cross-sectional study including 215 consecutive patients with migraine. Insomnia was defined as a Pittsburgh Sleep Quality Index (PSQI) global score greater than 5. Probable REM sleep behavior disorder (pRBD) was defined as an RBD screening score of 5 or greater. Excessive daytime sleepiness (EDS) was defined as an Epworth Sleepiness Scale score of 10 or higher. Suspected sleep apnea (SA) was defined as patients with snoring or sleep apnea witnessed 3 or more nights a week. CS was assessed by the Central Sensitization Inventory (CSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Restless legs syndrome, insomnia, EDS, SA and pRBD were observed in 25.6%, 71.6%, 34.4%, 10.2%, and 21.4%, respectively, of the patients. At least one sleep problem was present in 87.0% of the patients. According to the results of the multinomial logistic regression analysis with no sleep problems as a reference, after we corrected for adjustment factors, the Migraine Disability Assessment (MIDAS) score significantly increased when three or more comorbid sleep problems were present. According to our mediation analysis, an increased number of sleep problems had a direct effect on the MIDAS score after we adjusted for other variables, and the CSI score was indirectly involved in this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study showed an association between migraine-related disability and the burden of multiple sleep problems, which was partially mediated by CS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2024.1373574","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T06:29:41Z","timestamp":1711434581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations between the burdens of comorbid sleep problems, central sensitization, and headache-related disability in patients with migraine"],"prefix":"10.3389","volume":"15","author":[{"given":"Keisuke","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Haruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Sakuramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Kobashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/S0140-6736(18)30478-1","article-title":"Migraine","volume":"391","author":"Dodick","year":"2018","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41572-021-00328-4","article-title":"Migraine","volume":"8","author":"Ferrari","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/head.13358","article-title":"Sleep disorders and migraine: review of literature and potential pathophysiology mechanisms","volume":"58","author":"Vgontzas","year":"2018","journal-title":"Headache"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/head.13357","article-title":"Sleep and migraine: assessment and treatment of comorbid sleep disorders","volume":"58","author":"Rains","year":"2018","journal-title":"Headache"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11940-009-0056-y","article-title":"Sleep and headache","volume":"12","author":"Rains","year":"2010","journal-title":"Curr Treat Options Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s10194-020-01192-5","article-title":"Migraine and sleep disorders: a systematic review","volume":"21","author":"Tiseo","year":"2020","journal-title":"J Headache Pain"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1111\/head.12878","article-title":"A comparison of the chronic migraine epidemiology and outcomes (CaMEO) study and American migraine prevalence and prevention (AMPP) study: demographics and headache-related disability","volume":"56","author":"Lipton","year":"2016","journal-title":"Headache"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11916-017-0641-9","article-title":"Sleep in patients with chronic migraine","volume":"21","author":"Yang","year":"2017","journal-title":"Curr Pain Headache Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1526-4610.2007.00970.x","article-title":"Risk factors for headache chronification","volume":"48","author":"Scher","year":"2008","journal-title":"Headache"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"101889","DOI":"10.1016\/j.smrv.2023.101889","article-title":"Prevalence of headaches and their relationship with obstructive sleep apnea (OSA) - systematic review and meta-analysis","volume":"73","author":"Blaszczyk","year":"2024","journal-title":"Sleep Med Rev"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.sleep.2019.01.027","article-title":"The association between migraine and restless legs syndrome: an updated systematic review and meta-analysis","volume":"57","author":"Wang","year":"2019","journal-title":"Sleep Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1007\/s00415-011-6064-3","article-title":"Evaluation of contributing factors to restless legs syndrome in migraine patients","volume":"258","author":"Suzuki","year":"2011","journal-title":"J Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-018-0016-5","article-title":"REM sleep behaviour disorder","volume":"4","author":"Dauvilliers","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1177\/0333102413477742","article-title":"Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients","volume":"33","author":"Suzuki","year":"2013","journal-title":"Cephalalgia"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.2147\/NSS.S335949","article-title":"Current perspectives on the impact of chronic migraine on sleep quality: a literature review","volume":"14","author":"Sacmaci","year":"2022","journal-title":"Nat Sci Sleep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2174\/1573397112666151231110813","article-title":"Migraine and central sensitization: clinical features, Main comorbidities and therapeutic perspectives","volume":"12","author":"de Tommaso","year":"2016","journal-title":"Curr Rheumatol Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"S182","DOI":"10.1111\/j.1526-4610.2006.00602.x","article-title":"Central sensitization theory of migraine: clinical implications","volume":"46","author":"Dodick","year":"2006","journal-title":"Headache"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00415-020-10295-7","article-title":"Central sensitization in migraine is related to restless legs syndrome","volume":"268","author":"Suzuki","year":"2021","journal-title":"J Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/a0033820","article-title":"Robust mediation analysis based on median regression","volume":"19","author":"Yuan","year":"2014","journal-title":"Psychol Methods"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"22458","DOI":"10.1038\/s41598-022-26840-5","article-title":"A two-mediator serial mediation chain of the association between social isolation and impaired sleep in old age","volume":"12","author":"Gyasi","year":"2022","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"822564","DOI":"10.3389\/fpsyg.2022.822564","article-title":"Serial mediation roles of perceived stress and depressive symptoms in the association between sleep quality and life satisfaction among middle-aged American adults","volume":"13","author":"Yang","year":"2022","journal-title":"Front Psychol"},{"key":"ref22","first-page":"1","article-title":"Headache classification Committee of the International Headache Society (IHS) the international classification of headache disorders, 3rd edition","volume-title":"Cephalalgia","year":"2018"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1212\/WNL.53.5.988","article-title":"An international study to assess reliability of the migraine disability assessment (MIDAS) score","volume":"53","author":"Stewart","year":"1999","journal-title":"Neurology"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1533-2500.2011.00493.x","article-title":"The development and psychometric validation of the central sensitization inventory","volume":"12","author":"Mayer","year":"2012","journal-title":"Pain Pract"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e0188719","DOI":"10.1371\/journal.pone.0188719","article-title":"Validation of the Japanese version of the central sensitization inventory in patients with musculoskeletal disorders","volume":"12","author":"Tanaka","year":"2017","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.sleep.2014.03.025","article-title":"Restless legs syndrome\/Willis\u2013Ekbom disease diagnostic criteria: updated international restless legs syndrome study group (IRLSSG) consensus criteria \u2013 history, rationale, description, and significance","volume":"15","author":"Allen","year":"2014","journal-title":"Sleep Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1093\/sleep\/29.9.1155","article-title":"Recommendations for a standard research assessment of insomnia","volume":"29","author":"Buysse","year":"2006","journal-title":"Sleep"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0165-1781(00)00232-8","article-title":"Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh sleep quality index (PSQI-J) in psychiatric disordered and control subjects","volume":"97","author":"Doi","year":"2000","journal-title":"Psychiatry Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.sleep.2008.04.015","article-title":"Development of a Japanese version of the Epworth sleepiness scale (JESS) based on item response theory","volume":"10","author":"Takegami","year":"2009","journal-title":"Sleep Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.sleep.2009.05.007","article-title":"The REM sleep behavior disorder screening questionnaire: validation study of a Japanese version","volume":"10","author":"Miyamoto","year":"2009","journal-title":"Sleep Med"},{"key":"ref31","volume-title":"The Beck depression inventory","author":"Beck","year":"1996"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/j.1526-4610.2005.05159.x","article-title":"Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs","volume":"45","author":"Kelman","year":"2005","journal-title":"Headache"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e3554","DOI":"10.1097\/MD.0000000000003554","article-title":"Associations between sleep quality and migraine frequency: a cross-sectional case-control study","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/ene.13796","article-title":"Restless legs syndrome is associated with headache-related disabilities in patients with migraine: a prospective 7-year follow-up study","volume":"26","author":"Suzuki","year":"2019","journal-title":"Eur J Neurol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1111\/head.13313","article-title":"Cognitive-behavioral therapy for insomnia to reduce chronic migraine: a sequential Bayesian analysis","volume":"58","author":"Smitherman","year":"2018","journal-title":"Headache"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1046\/j.1365-2869.2001.00240.x","article-title":"The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects","volume":"10","author":"Onen","year":"2001","journal-title":"J Sleep Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e30845","DOI":"10.1097\/MD.0000000000030845","article-title":"Associations between insomnia and central sensitization in cancer survivors undergoing opioid therapy for chronic cancer pain: a STROBE-compliant prospective cohort study","volume":"101","author":"Akui","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1002\/acr.22609","article-title":"Sleep, pain catastrophizing, and central sensitization in knee osteoarthritis patients with and without insomnia","volume":"67","author":"Campbell","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e1968","DOI":"10.1002\/pri.1968","article-title":"Sleep quality in individuals with chronic low back pain and central sensitization","volume":"27","author":"Aoyagi","year":"2022","journal-title":"Physiother Res Int"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.adaj.2023.02.017","article-title":"Insomnia is associated with symptoms of central sensitization in patients with painful temporomandibular disorders","volume":"154","author":"Mercante","year":"2023","journal-title":"J Am Dent Assoc"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of migraine: a disorder of sensory processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol Rev"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10072-013-1369-x","article-title":"Central sensitization in photophobic and non-photophobic migraineurs: possible role of retino nuclear way in the central sensitization process","volume":"34","author":"Lovati","year":"2013","journal-title":"Neurol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10072-015-2141-1","article-title":"Osmophobia in allodynic migraineurs: cause or consequence of central sensitization?","volume":"36","author":"Lovati","year":"2015","journal-title":"Neurol Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1136\/jnnp.2009.198481","article-title":"Is phonophobia associated with cutaneous allodynia in migraine?","volume":"81","author":"Ashkenazi","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1468-2982.2006.01075.x","article-title":"The relationship between migraine pain and other associated symptoms","volume":"26","author":"Kelman","year":"2006","journal-title":"Cephalalgia"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10194-021-01294-8","article-title":"Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine","volume":"22","author":"Suzuki","year":"2021","journal-title":"J Headache Pain"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s13311-018-0616-5","article-title":"Glutamate and its receptors as therapeutic targets for migraine","volume":"15","author":"Hoffmann","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"6921","DOI":"10.1038\/s41598-022-10883-9","article-title":"Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine","volume":"12","author":"Park","year":"2022","journal-title":"Sci Rep"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","article-title":"Neural circuitry of wakefulness and sleep","volume":"93","author":"Scammell","year":"2017","journal-title":"Neuron"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"535","DOI":"10.5665\/sleep.3492","article-title":"Increased use-dependent plasticity in chronic insomnia","volume":"37","author":"Salas","year":"2014","journal-title":"Sleep"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1212\/WNL.0b013e318294b3f6","article-title":"Thalamic glutamate\/glutamine in restless legs syndrome: increased and related to disturbed sleep","volume":"80","author":"Allen","year":"2013","journal-title":"Neurology"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11916-016-0578-4","article-title":"Diverse physiological roles of calcitonin gene-related peptide in migraine pathology: modulation of neuronal-glial-immune cells to promote peripheral and central sensitization","volume":"20","author":"Durham","year":"2016","journal-title":"Curr Pain Headache Rep"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.1523\/JNEUROSCI.0576-17.2017","article-title":"Selective inhibition of Trigeminovascular neurons by Fremanezumab: a humanized monoclonal anti-CGRP antibody","volume":"37","author":"Melo-Carrillo","year":"2017","journal-title":"J Neurosci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s10194-021-01279-7","article-title":"Efficacy and safety of fremanezumab in patients with episodic and chronic migraine with documented inadequate response to 2 to 4 classes of migraine preventive medications over 6 months of treatment in the phase 3b FOCUS study","volume":"22","author":"Ashina","year":"2021","journal-title":"J Headache Pain"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1016\/j.cub.2014.09.077","article-title":"Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila","volume":"24","author":"Kunst","year":"2014","journal-title":"Curr Biol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"5539","DOI":"10.3390\/ijms22115539","article-title":"Migraine and sleep\u2014an unexplained association?","volume":"22","author":"Waliszewska-Prosol","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10194-011-0357-x","article-title":"Migraine and restless legs syndrome: is there an association?","volume":"12","author":"Cannon","year":"2011","journal-title":"J Headache Pain"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/WCO.0b013e3283378d5c","article-title":"Dopamine: what's new in migraine?","volume":"23","author":"Charbit","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"885020","DOI":"10.3389\/fneur.2022.885020","article-title":"Glymphatic system dysfunction: a novel mediator of sleep disorders and headaches","volume":"13","author":"Yi","year":"2022","journal-title":"Front Neurol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/ana.25122","article-title":"Inadequate brain glycogen or sleep increases spreading depression susceptibility","volume":"83","author":"Kilic","year":"2018","journal-title":"Ann Neurol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1046\/j.1526-4610.2003.03068.x","article-title":"Assessment of migraine disability using the migraine disability assessment (MIDAS) questionnaire: a comparison of chronic migraine with episodic migraine","volume":"43","author":"Bigal","year":"2003","journal-title":"Headache"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1373574\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T06:29:43Z","timestamp":1711434583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1373574\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":62,"alternative-id":["10.3389\/fneur.2024.1373574"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1373574","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"article-number":"1373574"}}