{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:36:27Z","timestamp":1771356987677,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Postinterventional hypothermia is a frequent complication in patients with large-vessel occlusion strokes (LVOS) after mechanical thrombectomy (MT). This inadvertent hypothermia might potentially have neuroprotective but also adverse effects on patients\u2019 outcomes. The aim of the study was to determine the rate of hypothermia in patients with LVOS receiving MT and its influence on functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a monocentric, retrospective study using a prospectively derived databank, including all LVOS patients receiving MT between 2015 and 2021. Predictive values of postinterventional body temperature and body temperature categories (hyperthermia (\u226538\u00b0C), normothermia (35\u00b0C\u201337.9\u00b0C), and hypothermia (&amp;lt;35\u00b0C)) on functional outcome were analyzed using multivariable Bayesian logistic regression models. Favorable outcome was defined as modified Rankin Scale (mRS) \u22643.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 480 included LVOS patients with MT (46.0% men; mean\u2009\u00b1\u2009SD age 73\u2009\u00b1\u200912.9\u2009years), 5 (1.0%) were hyperthermic, 382 (79.6%) normothermic, and 93 (19.4%) hypothermic. Postinterventional hypothermia was significantly associated with unfavorable functional outcome (mRS\u2009&amp;gt;\u20093) after 90\u2009days (OR 2.06, 95% CI 1.01\u20134.18, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). For short-term functional outcome, patients with hypothermia had a higher discharge NIHSS (OR 1.38, 95% CI 1.06 to 1.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.015) and a higher change of NIHSS from admission to discharge (OR 1.35, 95% CI 1.03 to 1.76, <jats:italic>p<\/jats:italic>\u2009=\u20090.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately a fifth of LVOS patients in this cohort were hypothermic after MT. Hypothermia was an independent predictor of unfavorable functional outcomes. Our findings warrant a prospective trial investigating active warming during MT.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1381872","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T06:25:25Z","timestamp":1717568725000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of inadvertent systemic hypothermia after mechanical thrombectomy in patients with large-vessel occlusion stroke"],"prefix":"10.3389","volume":"15","author":[{"given":"Kristina","family":"auf dem Brinke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"K\u00fcck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Jamous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Kunze-Szikszay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios-Nikos","family":"Psychogios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilko L.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","year":"2002","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S768","DOI":"10.1161\/CIRCULATIONAHA.110.971002","article-title":"Part 9: post-cardiac arrest care: 2010 american heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"122","author":"Peberdy","year":"2010","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.neuropharm.2017.08.025","article-title":"Therapeutic hypothermia for ischemic stroke; pathophysiology and future promise","volume":"134","author":"Kurisu","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1161\/STROKEAHA.116.014200","article-title":"Results of the ICTuS 2 trial (intravascular cooling in the treatment of stroke 2)","volume":"47","author":"Lyden","year":"2016","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1177\/2396987319844690","article-title":"Therapeutic hypothermia for acute ischaemic stroke. 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