{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T06:08:20Z","timestamp":1794204500295,"version":"4.8.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sudden sensorineural hearing loss (SSNHL) is a common emergency symptom in otolaryngology that requires immediate diagnosis and treatment. SSNHL has a multifactorial etiology, and its pathophysiologic mechanisms may be associated with inflammatory and metabolic changes that may affect the cochlear microenvironment or its nervous component, thus triggering the process or hindering hearing recovery. Therefore, the aim of this study was to assess metabolic and inflammatory changes to identify systemic parameters that could serve as prognostic factors for hearing recovery in patients with SSNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Thirty patients with a sudden hearing loss of at least 30\u2009dB in three contiguous frequencies were enrolled in this study. Patients were followed up for 4\u2009months and peripheral blood samples were collected at 7\u2009days (V1), 30\u2009days (V2) and 120\u2009days (V3). Interleukins (IL)-1F7, IL-2, IL-4, IL-5, IL-6, IL-10, interferon \u03b3 (IFN-\u03b3), tumor necrosis factor \u03b1 (TNF-\u03b1) and adiponectin were quantified in serum. In addition, lipid and glycemic profiles as well as concentration of creatinine, uric acid, fructosamine, peroxide, total proteins and albumin were analyzed. Patients underwent weekly ear-specific hearing tests with standard pure tone thresholds for frequencies of 250\u20138,000\u2009Hz, speech recognition threshold and word recognition score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with SSNHL were divided into a group of patients who did not achieve hearing recovery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) and another group who achieved complete and significant recovery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916). Most serologic parameters showed no significant changes or values indicating clinical changes. However, IFN-\u03b3 levels decreased by 36.3% between V1 and V2. The cytokine TNF-\u03b1 showed a statistically significant decrease from V1 to V3 (from 22.91 to 10.34\u2009pg.\/mL). Adiponectin showed a decrease from 553.7\u2009ng\/mL in V1 to 454.4\u2009ng\/mL in V3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our results show that serologic cytokine levels change in the acute phase of manifestation of SSNHL and establish a parallel between systemic changes and improvements in hearing, especially TNF-\u03b1, which showed differences in hearing recovery. The use of IFN-\u03b3, TNF-\u03b1 and adiponectin may elucidate the clinical improvement in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2024.1382096","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T01:06:14Z","timestamp":1719882374000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["The inflammatory and metabolic status of patients with sudden-onset sensorineural hearing loss"],"prefix":"10.3389","volume":"15","author":[{"given":"J\u00f4natas Bussador","family":"do Amaral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Abdo","family":"Peron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Lima Tavares","family":"Soeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Can\u00e7ado Passarelli","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Tatiana Pedrolo","family":"Hortense","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelly Damasceno","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Nunes","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Henrique da Silva","family":"Nali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luis Lacerda","family":"Bachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"de Oliveira Penido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"59885","DOI":"10.1177\/0194599819859885","article-title":"Clinical practice guideline: sudden hearing loss (update)","volume":"161","author":"Chandrasekhar","year":"2019","journal-title":"Otolaryngology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/MAO.0000000000003489","article-title":"Bilateral sudden sensorineural hearing loss: a distinct phenotype entity","volume":"43","author":"Elias","year":"2022","journal-title":"Otol Neurotol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"142459","DOI":"10.3389\/fneur.2023.1142459","article-title":"Comorbidities and laboratory changes of sudden sensorineural hearing loss: a review","volume":"14","author":"Xie","year":"2023","journal-title":"Front Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1127008","DOI":"10.3389\/fneur.2023.1127008","article-title":"Vestibular assessment in sudden sensorineural hearing loss: role in the prediction of hearing outcome and in the early detection of vascular and hydropic pathomechanisms","volume":"14","author":"Castellucci","year":"2023","journal-title":"Front Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3233\/VES-200703","article-title":"Vestibular function analysis of sudden sensorineural hearing loss with dizziness","volume":"30","author":"Lee","year":"2020","journal-title":"J Vestibular Res"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1002\/ohn.394","article-title":"Sudden sensorineural hearing loss following immunization with BNT162b2 or mRNA-1273: a Danish population-based cohort study","volume-title":"Otolaryngol Head Neck Surg","author":"Damkier","year":"2023"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"148","DOI":"10.21053\/ceo.2019.01858","article-title":"Machine learning models for predicting hearing prognosis in unilateral idiopathic sudden sensorineural hearing loss","volume":"13","author":"Park","year":"2020","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e96","DOI":"10.3390\/life12010096","article-title":"Effectiveness of various treatments for sudden sensorineural hearing loss-a retrospective study","volume":"12","author":"Skar\u017cy\u0144ska","year":"2022","journal-title":"Life"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1001\/jamaoto.2018.0648","article-title":"Association of vertigo with hearing outcomes in patients with sudden sensorineural hearing loss: a systematic review and meta-analysis","volume":"144","author":"Yu","year":"2018","journal-title":"JAMA Otolaryngol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1177\/0194599820986571","article-title":"Clinical profile of patients with unilateral sudden sensorineural hearing loss: correlation with hearing prognosis","volume":"165","author":"Perez Ferreira Neto","year":"2021","journal-title":"Otolaryngology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1080\/00016489.2020.1813328","article-title":"Topography of the lesion in idiopathic sudden sensorineural hearing loss","volume":"140","author":"Yigider","year":"2020","journal-title":"Acta Otolaryngol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1097\/00129492-200111000-00012","article-title":"Ultrastructural effects of hypercholesterolemia on the cochlea","volume":"22","author":"Satar","year":"2001","journal-title":"Otol Neurotol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1177\/15910199211056819","article-title":"Better late than never: initial experience of intra-arterial pulsed-urokinase-injection as a salvage therapy for refractory sudden sensorineural hearing loss","volume":"28","author":"Cui","year":"2022","journal-title":"Interv Neuroradiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"61385","DOI":"10.3390\/v15061385","article-title":"The pathogenesis of cytomegalovirus and other viruses associated with hearing loss: recent updates","volume":"15","author":"Shi","year":"2023","journal-title":"Viruses"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/7691473","article-title":"The role of autoimmunity in the pathogenesis of sudden sensorineural hearing loss","volume":"2018","author":"Li","year":"2018","journal-title":"Neural Plast"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"402","DOI":"10.12701\/jyms.2023.00304","article-title":"Association between fatty liver disease and hearing impairment in Korean adults: a retrospective cross-sectional study","volume":"40","author":"Jung","year":"2023","journal-title":"J Yeungnam Med Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3389\/fneur.2019.00977","article-title":"Cytokine levels in inner ear fluid of young and aged mice as molecular biomarkers of noise-induced hearing loss","volume":"10","author":"Landegger","year":"2019","journal-title":"Front Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/lary.31276","article-title":"Relevant research of inflammatory cytokines Spectrum in peripheral blood of sudden hearing loss","volume":"117","author":"Tan","year":"2024","journal-title":"Laryngoscope"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"41601","DOI":"10.1149\/2754-2726\/ac9227","article-title":"Review\u2014interleukins profiling for biosensing applications: possibilities and the future of disease detection","volume":"1","author":"Shekhar","year":"2022","journal-title":"ECS Sensors Plus"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4103\/ijpvm.IJPVM_193_20","article-title":"Adiponectin: role in physiology and pathophysiology","volume":"11","author":"Nguyen","year":"2020","journal-title":"Int J Prev Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/4367240","article-title":"Evidence supporting the hypothesis that inflammation-induced vasospasm is involved in the pathogenesis of acquired sensorineural hearing loss","volume":"2019","author":"Eisenhut","year":"2019","journal-title":"Int J Otolaryngol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"109488","DOI":"10.1016\/j.intimp.2022.109488","article-title":"Spatial architecture of the cochlear immune microenvironment in noise-induced and age-related sensorineural hearing loss","volume":"114","author":"Li","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bbi.2019.09.020","article-title":"Association of inflammatory markers with hearing impairment: the English longitudinal study of ageing","volume":"83","author":"Lassale","year":"2020","journal-title":"Brain Behav Immun"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1017\/S0022215119000100","article-title":"Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss","volume":"133","author":"Yoon","year":"2019","journal-title":"J Laryngol Otol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e712","DOI":"10.1097\/MAO.0000000000003552","article-title":"Serum fibrinogen level and cytokine production as prognostic biomarkers for idiopathic sudden sensorineural hearing loss","volume":"43","author":"Okuda","year":"2022","journal-title":"Otol Neurotol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00405-020-05808-z","article-title":"Metabolic syndrome components and sudden sensorineural hearing loss: a case-control study","volume":"277","author":"Jalali","year":"2020","journal-title":"Eur Arch Otorrinolaringol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1055\/s-0040-1714130","article-title":"Evaluation of oxidative-stress pathway and recovery of sudden sensorineural hearing loss","volume":"25","author":"Elias","year":"2021","journal-title":"Int Arch Otorhinolaryngol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"234","DOI":"10.4081\/audiores.2020.234","article-title":"Sudden sensorineural hearing loss: what factors influence the response to therapy?","volume":"10","author":"Sciancalepore","year":"2020","journal-title":"Audiol Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00129492-200205000-00013","article-title":"Hyperfibrinogenemia as a risk factor for sudden hearing loss","volume":"23","author":"Suckf\u00fcll","year":"2002","journal-title":"Otol Neurotol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e0133300","DOI":"10.1371\/journal.pone.0133300","article-title":"High Total cholesterol in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss","volume":"10","author":"Quaranta","year":"2015","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"246","DOI":"10.21608\/BMFJ.2022.143421.1604","article-title":"Lipid profile in patients with idiopathic sudden sensorineural hearing loss","volume":"40","author":"Hashim","year":"2023","journal-title":"Benha Med J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00405-016-4301-1","article-title":"A comprehensive study of oxidative stress in sudden hearing loss","volume":"274","author":"Gul","year":"2017","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1007\/s12070-019-01623-z","article-title":"Assessment of oxidative stress in patients with sudden hearing loss: a non-randomized prospective clinical study","volume":"71","author":"Ozdamar","year":"2019","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1177\/0194599814521012","article-title":"Hyperglycemia as a potential prognostic factor of idiopathic sudden sensorineural hearing loss","volume":"150","author":"Ryu","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"158955","DOI":"10.3389\/fneur.2023.1158955","article-title":"Time from sudden sensory neural hearing loss to treatment as a prognostic factor","volume":"14","author":"Chen","year":"2023","journal-title":"Front Neurol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1177\/01945998221087664","article-title":"Systemic steroids for otolaryngology-head and neck surgery disorders: an evidence-based primer for clinicians","volume":"168","author":"McCoul","year":"2023","journal-title":"Otolaryngology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1590\/S0034-89101992000600009","article-title":"\u00cdndice de massa corporal (massa corporal.estatura-2) como indicador do estado nutricional de adultos: revis\u00e3o da literatura","volume":"26","author":"Anjos","year":"1992","journal-title":"Rev Saude Publica"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s00405-023-08289-y","article-title":"A prognostic value of estimated pulse wave velocity in idiopathic sudden sensorineural hearing loss","volume":"281","author":"Seo","year":"2023","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12199-020-00862-9","article-title":"Body mass index, waist circumference, and risk of hearing loss: a meta-analysis and systematic review of observational study","volume":"25","author":"Yang","year":"2020","journal-title":"Environ Health Prev Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.clnu.2019.03.020","article-title":"Obesity and risk of hearing loss: a prospective cohort study","volume":"39","author":"Hu","year":"2020","journal-title":"Clin Nutr"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.3390\/ijms21103570","article-title":"Adipokines and obesity. Potential link to metabolic disorders and chronic complications","volume":"21","author":"Zorena","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13293-023-00493-z","article-title":"Sex differences in hearing impairment due to diet-induced obesity in CBA\/ca mice","volume":"14","author":"Kim","year":"2023","journal-title":"Biol Sex Differ"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1038\/cddis.2014.140","article-title":"Adiponectin deficiency exacerbates age-related hearing impairment","volume":"5","author":"Tanigawa","year":"2014","journal-title":"Cell Death Dis"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1016\/j.neurobiolaging.2015.02.030","article-title":"Contribution of adiponectin and its type 1 receptor to age-related hearing impairment","volume":"36","author":"Wu","year":"2015","journal-title":"Neurobiol Aging"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cyto.2016.06.028","article-title":"Adiponectin, TNF-\u03b1 and inflammatory cytokines and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"86","author":"Liu","year":"2016","journal-title":"Cytokine"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1038\/s41598-017-03319-2","article-title":"Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis","volume":"7","author":"Ren","year":"2017","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"100001","DOI":"10.1194\/jlr.RA120000767","article-title":"Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects","volume":"62","author":"Kakino","year":"2021","journal-title":"J Lipid Res"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3892\/ijmm.2019.4072","article-title":"Adiponectin protects against uric acid-induced renal tubular epithelial inflammatory responses via the AdipoR1\/AMPK signaling pathway","volume":"43","author":"Yang","year":"2019","journal-title":"Int J Mol Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1590\/S1808-86942010000300015","article-title":"Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias","volume":"76","author":"Nagaoka","year":"2010","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.3390\/jcm12082861","article-title":"Association between chronic kidney disease and sudden sensorineural hearing loss: a longitudinal follow-up studies using ICD-10 codes in a National Health Screening Cohort","volume":"12","author":"Shim","year":"2023","journal-title":"J Clin Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000530686","article-title":"Cardiovascular risk factors, cerebral small vessel disease, and subsequent risk of stroke in patients with idiopathic sudden sensorineural hearing loss: systematic review and meta-analyses of the current literature","volume":"29","author":"Oussoren","year":"2023","journal-title":"Audiol Neurootol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1002\/brx2.34","article-title":"Understanding the role of inflammation in sensorineural hearing loss: current goals and future prospects","volume":"1","author":"Li","year":"2023","journal-title":"Brain-X"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"216387","DOI":"10.3390\/jcm11216387","article-title":"Update on findings about sudden sensorineural hearing loss and insight into its pathogenesis","volume":"11","author":"Yamada","year":"2022","journal-title":"J Clin Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"927235","DOI":"10.3389\/fneur.2022.927235","article-title":"Correlation between the prognosis of sudden Total deafness and the peripheral blood inflammation markers","volume":"13","author":"Diao","year":"2022","journal-title":"Front Neurol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3390\/medicina58070963","article-title":"Digging into the role of inflammatory biomarkers in sudden sensorineural hearing loss diagnosis and prognosis: a systematic review and meta-analysis","volume":"58","author":"Frosolini","year":"2022","journal-title":"Medicina"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fimmu.2023.1278521","article-title":"Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process","volume":"14","author":"Gu","year":"2023","journal-title":"Front Immunol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"60723","DOI":"10.3390\/brainsci12060723","article-title":"Recent advances in progresses and prospects of IL-37 in central nervous system diseases","volume":"12","author":"Li","year":"2022","journal-title":"Brain Sci"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"696605","DOI":"10.3389\/fimmu.2021.696605","article-title":"Current understanding of IL-37 in human health and disease","volume":"12","author":"Su","year":"2021","journal-title":"Front Immunol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"14224","DOI":"10.1074\/jbc.RA118.003698","article-title":"Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue","volume":"293","author":"Ballak","year":"2018","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3342\/kjorl-hns.2021.00059","article-title":"Tumor necrosis factor-alpha and Interleukin-4 levels in patients with idiopathic sudden sensorineural hearing loss","volume":"64","author":"Kim","year":"2021","journal-title":"Korean J Otorhinolaryngol-Head Neck Surg"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000442016","article-title":"The expression of TNF\u03b1, IL-6, IL-2 and IL-8 in the serum of patients with idiopathic sudden sensorineural hearing loss: possible prognostic factors of response to corticosteroid treatment","volume":"6","author":"Tsinaslanidou","year":"2016","journal-title":"Audiol Neurotol Extra"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.3389\/fnmol.2023.1243370","article-title":"Human blood-labyrinth barrier model to study the effects of cytokines and inflammation","volume":"16","author":"Sekulic","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neures.2009.12.008","article-title":"Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea","volume":"66","author":"Wakabayashi","year":"2010","journal-title":"Neurosci Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1097\/AUD.0000000000000678","article-title":"Biomarkers of systemic inflammation and risk of incident hearing loss","volume":"40","author":"Gupta","year":"2019","journal-title":"Ear Hear"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1016\/j.ajpath.2020.05.007","article-title":"The surprising story of IL-2: from experimental models to clinical application","volume":"190","author":"Abbas","year":"2020","journal-title":"Am J Pathol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1159\/000027609","article-title":"Interleukin-2 affects cochlear function gradually but reversibly","volume":"60","author":"Kubo","year":"1998","journal-title":"ORL J Oto-Rhino-Laryngol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1177\/000348940211101107","article-title":"Sudden sensorineural hearing loss: supporting the immunologic theory","volume":"111","author":"Berrocal","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1258\/0022215001905021","article-title":"Immune response and immunopathology of the inner ear: an update","volume":"114","author":"Garc\u00eda Berrocal","year":"2000","journal-title":"J Laryngol Otol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fphys.2019.01514","article-title":"Interleukin-5 in the pathophysiology of severe asthma","volume":"10","author":"Pelaia","year":"2019","journal-title":"Front Physiol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"991449","DOI":"10.1177\/2473974X21991449","article-title":"Role of interleukin 5 inhibition in the treatment of eosinophilic otitis media","volume":"5","author":"Breslin","year":"2021","journal-title":"OTO Open"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1161067","DOI":"10.3389\/fimmu.2023.1161067","article-title":"The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions","volume":"14","author":"Carlini","year":"2023","journal-title":"Front Immunol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3389\/fncel.2017.00314","article-title":"Interleukin-10 attenuates hypochlorous acid-mediated cytotoxicity to HEI-OC1 Cochlear cells","volume":"11","author":"Mwangi","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/lary.23907","article-title":"Blood levels of TNF-\u03b1, IL-10, and IL-12 in idiopathic sudden sensorineural hearing loss","volume":"123","author":"Demirhan","year":"2013","journal-title":"Laryngoscope"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s40136-018-0186-4","article-title":"The role of tumor necrosis factor alpha (TNF\u03b1)in hearing loss and vestibular schwannomas","volume":"6","author":"Ren","year":"2018","journal-title":"Curr Otorhinolaryngol Rep"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fncel.2019.00444","article-title":"Targeting inflammatory processes mediated by TRPVI and TNF-\u03b1 for treating noise-induced hearing loss","volume":"13","author":"Dhukhwa","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"e0291780","DOI":"10.1371\/journal.pone.0291780","article-title":"Dexamethasone treatment of murine auditory hair cells and cochlear explants attenuates tumor necrosis factor-\u03b1-initiated apoptotic damage","volume":"18","author":"Kang","year":"2023","journal-title":"PLoS One"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1097\/MAO.0000000000001095","article-title":"Tumor necrosis factor-induced decrease of cochlear blood flow can be reversed by Etanercept or JTE-013","volume":"37","author":"Sharaf","year":"2016","journal-title":"Otol Neurotol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"82692","DOI":"10.3390\/ijms21082692","article-title":"New insights on the effect of TNF alpha blockade by gene silencing in noise-induced hearing loss","volume":"21","author":"Rodrigues","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1001\/2013.jamaoto.76","article-title":"Diagnostic and prognostic utility of measuring tumor necrosis factor in the peripheral circulation of patients with immune-mediated sensorineural hearing loss","volume":"138","author":"Svrakic","year":"2012","journal-title":"Arch Otolaryngol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/lary.20050","article-title":"Utility of anti-HSP 70, TNF-\u03b1, ESR, antinuclear antibody, and antiphospholipid antibodies in the diagnosis and treatment of sudden sensorineural hearing loss","volume":"119","author":"S\u00fcsl\u00fc","year":"2009","journal-title":"Laryngoscope"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/B978-012374410-4.00374-5","article-title":"Cytokines and chemokines","volume-title":"Encyclopedia of virology","author":"Griffin","year":"2008"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"8S","DOI":"10.1177\/0003489419837689","article-title":"Involvement of TNF-\u03b1 and IFN-\u03b3 in inflammation-mediated Cochlear injury","volume":"128","author":"Moon","year":"2019","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1382096\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T01:06:19Z","timestamp":1719882379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1382096\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":85,"alternative-id":["10.3389\/fneur.2024.1382096"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1382096","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"article-number":"1382096"}}