{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:59:34Z","timestamp":1783702774219,"version":"3.55.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Growing evidence suggests that headache disorders and atopic dermatitis share similar pathological mechanisms and risk factors. The aim of this study was to assess the risk for headache disorders in patients with atopic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched the PubMed and Embase databases from inception to December 1, 2023, for observational studies that examined risk of migraine in subjects with atopic dermatitis. Risk estimates from individual studies were pooled using random-effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies with 12,717,747 subjects were included in the meta-analysis. Our results showed that patients with atopic dermatitis were associated with a higher risk of headache disorder (OR, 1.46, 95% CI\u2009=\u20091.36\u20131.56; <jats:italic>P<\/jats:italic> &amp;lt;\u20090.001; I<jats:sup>2<\/jats:sup>\u2009=\u200998%) or migraine (OR, 1.32, 95% CI\u2009=\u20091.18\u20131.47; <jats:italic>P<\/jats:italic> &amp;lt;\u20090.001; I<jats:sup>2<\/jats:sup>\u2009=\u200998.9%). Most of the results of the subgroup analyses were consistent with the overall results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this meta-analysis suggest that atopic dermatitis is a potential risk indicator for headache disorder or migraine. Further studies are still needed to verify our findings due to the substantial heterogeneity in our analyses.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1383832","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T04:51:53Z","timestamp":1710996713000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses"],"prefix":"10.3389","volume":"15","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-yin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-yuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/s1474-4422(12)70139-4","article-title":"Advances and challenges in neurostimulation for headaches","volume":"11","author":"Magis","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3331024231168089","DOI":"10.1177\/03331024231168089","article-title":"New daily persistent headache: a systematic review and meta-analysis","volume":"43","author":"Cheema","year":"2023","journal-title":"Cephalalgia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s10194-024-01712-7","article-title":"Health equity, care access and quality in headache - part 1","volume":"25","author":"Tana","year":"2024","journal-title":"J Headache Pain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1093\/brain\/awh146","article-title":"A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth","volume":"127","author":"Mitsikostas","year":"2004","journal-title":"Brain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1526-4610.2012.02260.x","article-title":"Prevalence of migraine in patients with celiac disease and inflammatory bowel disease","volume":"53","author":"Dimitrova","year":"2013","journal-title":"Headache"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.job.2023.04.001","article-title":"The association between migraines and periodontal disease: a systematic review of clinical studies","volume":"65","author":"Dholakia","year":"2023","journal-title":"J Oral Biosci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5114\/ada.2022.119009","article-title":"The increase in allergic conditions based on a review of literature","volume":"40","author":"Gutowska-\u015alesik","year":"2023","journal-title":"Postepy Dermatol Alergol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/s0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s10194-023-01547-8","article-title":"Genetics of migraine: where are we now?","volume":"24","author":"Grangeon","year":"2023","journal-title":"J Headache Pain"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/head.14111","article-title":"Indomethacin-responsive headaches: a narrative review","volume":"61","author":"Villar-Mart\u00ednez","year":"2021","journal-title":"Headache"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"741135","DOI":"10.3389\/falgy.2021.741135","article-title":"Association between asthma and migraine: a systematic review and meta-analysis of observational studies","volume":"2","author":"Kang","year":"2021","journal-title":"Front Allergy"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"609528","DOI":"10.3389\/fmed.2020.609528","article-title":"The comorbid relationship between migraine and asthma: a systematic review and meta-analysis of population-based studies","volume":"7","author":"Wang","year":"2020","journal-title":"Front Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.pjnns.2018.07.004","article-title":"Which came first, the risk of migraine or the risk of asthma? 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