{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T22:18:02Z","timestamp":1794435482923,"version":"4.9.1"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post-stroke dysphagia (PSD) is associated with various complications that increase morbidity and mortality rates. Acupuncture has been used extensively in China to treat these complications; however, its therapeutic efficacy remains uncertain. We therefore aimed to study the clinical effects of acupuncture on PSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic> =\u2009101) were randomly divided into acupuncture (<jats:italic>n<\/jats:italic> =\u200950) and rehabilitation training control (<jats:italic>n<\/jats:italic> =\u200951) groups based on the treatment used. Both groups were treated once daily, 6\u2009days a week, for a total of 4\u2009weeks. Pulse oxygen saturation (SpO2) and standardized swallowing assessment (SSA) were performed before the intervention, 2\u2009weeks into treatment, after the intervention (4\u2009weeks post-intervention), and at a 6-month follow-up (28\u2009weeks). The levels of hemoglobin (Hb) and albumin (ALB), and 5-hydroxytryptamine (5-HT) and dopamine (DA) were measured before the intervention, 2\u2009weeks into treatment, and after the intervention (4\u2009weeks), as nutrition and swallowing function indices, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following the intervention, significant differences were observed between the acupuncture and control groups. The acupuncture group exhibited considerably superior enhancements in SpO2 and SSA scores at 4\u2009weeks (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.001). Moreover, this group demonstrated significantly greater improvements in Hb, ALB, 5-HT, and DA values 4\u2009weeks post-treatment (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.001). However, sex-based differences were not observed (<jats:italic>P<\/jats:italic> &amp;gt; 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acupuncture treatment can improve the swallowing function and nutritional status of patients with PSD, and increase the levels of 5-HT and DA. These findings strongly support the efficacy of acupuncture as a therapeutic intervention in patients with PSD.<\/jats:p><jats:p><jats:bold>Clinical<\/jats:bold><jats:bold>trial registration:<\/jats:bold> identifier, ChiCTR2100052201. (<jats:ext-link>https:\/\/www.chictr.org.cn\/<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1391226","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T04:26:12Z","timestamp":1718943972000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of acupuncture on post-stroke dysphagia: a randomized controlled trial"],"prefix":"10.3389","volume":"15","author":[{"given":"Lin","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Shilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1161\/01.STR.30.4.744","article-title":"Swallowing 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