{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:35:38Z","timestamp":1792802138208,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In the COGNitive in Focused UltraSound (COGNIFUS) study, we examined the 6-month cognitive outcomes of patients undergoing MRgFUS thalamotomy. This study endorsed the safety profile of the procedure in terms of cognitive functions that cannot be evaluated in real-time during the procedure unlike other aspects. The aim of the COGNIFUS Part 2 study was to investigate the cognitive trajectory of MRgFUS patients over a 1-year period, in order to confirm long-term safety and satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively evaluated the cognitive and neurobehavioral profile of patients with essential tremor (ET) or Parkinson\u2019s Disease (PD) related tremor undergoing MRgFUS thalamotomy at 1\u2009year-follow-up following the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample consists of 50 patients (male 76%; mean age\u2009\u00b1\u2009SD 69.0\u2009\u00b1\u20098.56; mean disease duration\u2009\u00b1\u2009SD 12.13\u2009\u00b1\u200912.59; ET 28, PD 22 patients). A significant improvement was detected at the 1\u2009year-follow-up assessment in anxiety and mood feelings (Hamilton Anxiety rating scale 5.66\u2009\u00b1\u20095.02 vs. 2.69\u2009\u00b1\u20093.76, <jats:italic>p<\/jats:italic>\u2009\u2264\u2009&amp;lt;0.001; Beck depression Inventory II score 3.74\u2009\u00b1\u20093.80 vs. 1.80\u2009\u00b1\u20092.78, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), memory domains (Rey Auditory Verbal Learning Test, immediate recall 31.76\u2009\u00b1\u20097.60 vs. 35.38\u2009\u00b1\u20097.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.001 and delayed recall scores 5.57\u2009\u00b1\u20092 0.75 vs. 6.41\u2009\u00b1\u20092.48), frontal functions (Frontal Assessment Battery score 14.24\u2009\u00b1\u20093.04 vs. 15.16\u2009\u00b1\u20092.74) and in quality of life (Quality of life in Essential Tremor Questionnaire 35.00\u2009\u00b1\u200912.08 vs. 9.03\u2009\u00b1\u200910.64, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001 and PD Questionnaire \u22128 7.86\u2009\u00b1\u20093.10 vs. 3.09\u2009\u00b1\u20092.29, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study supports the long-term efficacy and cognitive safety of MRgFUS treatment for ET and PD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1395282","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T04:31:54Z","timestamp":1718598714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Cognitive safety of focused ultrasound thalamotomy for tremor: 1-year follow-up results of the COGNIFUS part 2 study"],"prefix":"10.3389","volume":"15","author":[{"given":"Gennaro","family":"Saporito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Sucapane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Catalucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Masciocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Pistoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Splendiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Di Cesare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Totaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pistoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/mds.27121","article-title":"Tremor task force of the International Parkinson and Movement Disorder Society. 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