{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:51:30Z","timestamp":1788288690531,"version":"build-2803163510"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Deep Brain Stimulation (DBS) effectively treats Parkinson\u2019s motor symptoms, but its effects on the urogenital system are debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A research was conducted in PubMed, Embase, Cochrane Library, Web of Science, and Scopus until February 27, 2024. We primarily focused on DBS\u2019s impact on Parkinson\u2019s patients\u2019 Urine storage function, voiding function, sexual function, and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our meta-analysis included 14 studies. The main results showed that DBS resulted in fewer instances of urinary urgency (OR\u2009=\u20091.85, 95% CI: 1.26 to 2.70, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and increased maximum bladder capacity (MD\u2009=\u2009\u221266.10, 95% CI: \u2212119.37 to \u221212.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) in terms of urinary storage function. However, there were no significant differences in first desire to void and strong desire to void. In terms of voiding function, DBS showed significant improvements in maximum flow rate (MD\u2009=\u2009\u22120.64, 95% CI: \u22121.23 to \u22120.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), post-void residual (MD\u2009=\u2009\u22126.79, 95% CI: 4.54 to 9.05, <jats:italic>P<\/jats:italic> &amp;lt;\u20090.00001) and detrusor pressure during maximum flow (MD\u2009=\u2009\u22121.37, 95% CI: \u22122.73 to \u22120.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.05). Additionally, there was no significant difference in sexual function between the two groups (MD\u2009=\u2009\u22121.41, 95% CI: \u221212.40 to 9.57, <jats:italic>p<\/jats:italic>\u2009=\u20090.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DBS has demonstrated a certain degree of efficacy in ameliorating urinary storage and voiding function in patients with Parkinson\u2019s disease. However, certain urodynamic parameters or scores do not demonstrate any statistically significant disparities. Furthermore, DBS has no significant impact on erectile function in male Parkinson\u2019s patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023476661<\/jats:ext-link>, identifier CRD42023476661.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1397344","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T04:28:45Z","timestamp":1720067325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of deep brain stimulation on urogenital function in Parkinson\u2019s disease: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Long","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s11065-020-09467-z","article-title":"Deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease: a meta-analysis of mood effects","volume":"31","author":"Tomas","year":"2021","journal-title":"Neuropsychol Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1269864","DOI":"10.3389\/fnhum.2023.1269864","article-title":"Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson\u2019s disease","volume":"17","author":"Memon","year":"2023","journal-title":"Front Hum Neurosci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e683","DOI":"10.1016\/j.wneu.2021.07.112","article-title":"Bilateral subthalamic nucleus deep brain stimulation improves gastric emptying time in Parkinson disease","volume":"154","author":"Wang","year":"2021","journal-title":"World Neurosurg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1002\/mds.22643","article-title":"The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson\u2019s disease","volume":"24","author":"Barone","year":"2009","journal-title":"Mov Disord"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.parkreldis.2020.08.032","article-title":"Deep brain stimulation effects on lower urinary tract function: systematic review and meta-analysis","volume":"79","author":"J\u00f6rg","year":"2020","journal-title":"Parkinsonism Relat Disord"},{"key":"ref6","year":"2020"},{"key":"ref7","year":"2021"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","article-title":"Methodological index for non-randomized studies (minors): development and validation of a new instrument","volume":"73","author":"Slim","year":"2003","journal-title":"ANZ J Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/nau.23321","article-title":"Effects of pedunculopontine nucleus stimulation on human bladder function","volume":"37","author":"Roy","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e9750","DOI":"10.1097\/MD.0000000000009750","article-title":"Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson\u2019s disease: an open prospective single institution study","volume":"97","author":"Kurcova","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e01164","DOI":"10.1002\/brb3.1164","article-title":"Urinary symptoms are correlated with quality of life after deep brain stimulation in Parkinson\u2019s disease","volume":"8","author":"Yamamoto","year":"2018","journal-title":"Brain Behav"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.2147\/CIA.S204368","article-title":"Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson\u2019s disease","volume":"14","author":"Zong","year":"2019","journal-title":"Clin Interv Aging"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/NRL.0000000000000272","article-title":"The impact of deep brain stimulation on the sexual function of patients with Parkinson\u2019s disease","volume":"25","author":"Pedro","year":"2020","journal-title":"Neurologist"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.2147\/NDT.S342236","article-title":"Effect of deep brain stimulation on female parkinsonian patients with lower urinary tract symptoms","volume":"17","author":"Liang","year":"2021","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1016\/j.euf.2022.05.004","article-title":"Effects of deep brain stimulation on lower urinary tract function in neurological patients","volume":"8","author":"Sartori","year":"2022","journal-title":"Eur Urol Focus"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.parkreldis.2012.05.011","article-title":"Immediate effects of deep brain stimulation of the subthalamic nucleus on nonmotor symptoms in Parkinson\u2019s disease","volume":"18","author":"Wolz","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1097\/01.ju.0000055520.88377.dc","article-title":"Effects of subthalamic nucleus stimulation on urodynamic findings in patients with Parkinson\u2019s disease","volume":"169","author":"Finazzi-Agr\u00f2","year":"2003","journal-title":"J Urol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/ana.10806","article-title":"Effect of subthalamic deep brain stimulation on the function of the urinary bladder","volume":"55","author":"Seif","year":"2004","journal-title":"Ann Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1093\/brain\/awl302","article-title":"Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson\u2019s disease","volume":"129","author":"Herzog","year":"2006","journal-title":"Brain"},{"key":"ref20","first-page":"609","article-title":"Effects of deep brain stimulation on urodynamic findings in patients with Parkinson\u2019s disease","volume":"53","author":"Shimizu","year":"2007","journal-title":"Hinyokika Kiyo"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1093\/brain\/awm254","article-title":"Improved sensory gating of urinary bladder afferents in Parkinson\u2019s disease following subthalamic stimulation","volume":"131","author":"Herzog","year":"2008","journal-title":"Brain"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/ner.12446","article-title":"The impact of pallidal and subthalamic deep brain stimulation on urologic function in Parkinson\u2019s disease","volume":"19","author":"Mock","year":"2016","journal-title":"Neuromodulation"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1002\/mds.25225","article-title":"Weak detrusor contractility correlates with motor disorders in Parkinson\u2019s disease","volume":"27","author":"Terayama","year":"2012","journal-title":"Mov Disord"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00192-009-1030-7","article-title":"Objective differences between overactive bladder patients with and without urodynamically proven detrusor overactivity","volume":"21","author":"Guralnick","year":"2010","journal-title":"Int Urogynecol J"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2147\/RRU.S411841","article-title":"Vibegron 50 mg once daily improves OABSS, OAB-q SF score in OAB patients \u226580 years old in real-world clinical settings and switching from other OAB drugs may reduce residual urine volume","volume":"15","author":"Kuno","year":"2023","journal-title":"Res Rep Urol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/iju.12421","article-title":"Bladder function of patients with Parkinson\u2019s disease","volume":"21","author":"Sakakibara","year":"2014","journal-title":"Int J Urol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/s0022-5347(17)51929-1","article-title":"Neurourologic findings in Parkinson\u2019s disease","volume":"129","author":"Pavlakis","year":"1983","journal-title":"J Urol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/mdc3.12374","article-title":"Nocturia in Parkinson\u2019s disease: why does it occur and how to manage?","volume":"3","author":"Batla","year":"2016","journal-title":"Mov Disord Clin Pract"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1464-410X.2011.10175.x","article-title":"The evaluation and treatment of nocturia: a consensus statement","volume":"108","author":"Weiss","year":"2011","journal-title":"BJU Int"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.nbd.2011.10.002","article-title":"Pathophysiology of bladder dysfunction in Parkinson\u2019s disease","volume":"46","author":"Sakakibara","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.parkreldis.2015.02.025","article-title":"Randomized, controlled pilot trial of solifenacin succinate for overactive bladder in Parkinson\u2019s disease","volume":"21","author":"Zesiewicz","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/mds.22631","article-title":"Acute urinary retention in two patients after subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of advanced Parkinson\u2019s disease","volume":"24","author":"Fritsche","year":"2009","journal-title":"Mov Disord"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ibneur.2023.10.004","article-title":"Decreased bladder contraction interval induced by periaqueductal grey stimulation is reversed by subthalamic stimulation in a Parkinson\u2019s disease model rat","volume":"15","author":"Yamamoto","year":"2023","journal-title":"IBRO Neurosci Rep"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/nau.20224","article-title":"Neurological diseases that cause detrusor hyperactivity with impaired contractile function","volume":"25","author":"Yamamoto","year":"2006","journal-title":"Neurourol Urodyn"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/bs.irn.2017.03.002","article-title":"Treatment of nonmotor symptoms in Parkinson\u2019s disease","volume":"132","author":"Sauerbier","year":"2017","journal-title":"Int Rev Neurobiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1093\/aje\/kwm246","article-title":"Erectile function and risk of Parkinson\u2019s disease","volume":"166","author":"Gao","year":"2007","journal-title":"Am J Epidemiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.jsxm.2020.06.010","article-title":"Sexual dysfunction in Parkinson disease: a multicenter Italian cross-sectional study on a still overlooked problem","volume":"17","author":"Raciti","year":"2020","journal-title":"J Sex Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1002\/mds.26739","article-title":"Sexual dysfunction in women with Parkinson\u2019s disease","volume":"31","author":"Varanda","year":"2016","journal-title":"Mov Disord"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1136\/jnnp.2003.034579","article-title":"Sexual well being in parkinsonian patients after deep brain stimulation of the subthalamic nucleus","volume":"75","author":"Castelli","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00429-014-0911-9","article-title":"Cortico-basal ganglia circuits involved in different motivation disorders in non-human primates","volume":"221","author":"Sgambato-Faure","year":"2016","journal-title":"Brain Struct Funct"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4103\/0028-3886.132453","article-title":"Hypersexuality after bilateral deep brain stimulation of the subthalamic nucleus for Parkinson\u2019s disease","volume":"62","author":"Akakin","year":"2014","journal-title":"Neurol India"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/mds.10265","article-title":"Transient mania with hypersexuality after surgery for high frequency stimulation of the subthalamic nucleus in Parkinson\u2019s disease","volume":"17","author":"Romito","year":"2002","journal-title":"Mov Disord"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.3760\/cma.j.issn.0366-6999.2010.11.016","article-title":"Study of an integrated non-motor symptoms questionnaire for Parkinson\u2019s disease","volume":"123","author":"Yu","year":"2010","journal-title":"Chin Med J"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/mds.23462","article-title":"The impact of non-motor symptoms on health-related quality of life of patients with Parkinson\u2019s disease","volume":"26","author":"Martinez-Martin","year":"2011","journal-title":"Mov Disord"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/ene.13290","article-title":"The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson\u2019s disease","volume":"24","author":"Picillo","year":"2017","journal-title":"Eur J Neurol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1397344\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T04:28:50Z","timestamp":1720067330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1397344\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":45,"alternative-id":["10.3389\/fneur.2024.1397344"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1397344","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]},"article-number":"1397344"}}