{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:22:34Z","timestamp":1788193354446,"version":"build-2803163510"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the feasibility and safety of conducting robot-mediated impairment training (RMIT) and robot-mediated task-specific training (RMTT). The device deployed is the Optimo Regen (OR<jats:sup>\u00ae<\/jats:sup>), capable of delivering both impairment-oriented training and task-specific training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single-centre, randomized, single-blinded, two-arm, parallel group, controlled trial. Patients fulfilling criteria were randomized into either the RMIT or RMIT + RMTT group and provided with 20\u2009h of robotic therapy on top of standard care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4 patients were recruited, with 2 patients receiving treatment in each arm. The study was feasible, with a 66.7% enrolment rate, 75% completion rate, and 100% attendance for each intervention session. We achieved a 90% satisfaction rate with no serious adverse effects. All patients had improvement of motor power, Fugl-Meyer Assessment-Upper Extremity (FMA-UE), Functional Independence Measure (FIM), Hospital Anxiety and Depression Scale (HADS), and quality of life scores at 1\u2009month. FIM continued to improve at 3\u2009months post-commencement of intervention. There was relative ease of use of the device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This trial is feasible. A full-scale study is warranted, to compare RMIT against RMTT, which is a novel application.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1415773","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T04:43:20Z","timestamp":1728621800000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Robot-mediated impairment-oriented and task-specific training on upper limb post stroke: feasibility and preliminary effects on physical function and quality of life"],"prefix":"10.3389","volume":"15","author":[{"given":"San San","family":"Tay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Alejandro","family":"Visperas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan Han","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borisut","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Rui Edmund","family":"Neo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1747-4949.2008.00181.x","article-title":"Burden of stroke in Singapore","volume":"3","author":"Venketasubramanian","year":"2008","journal-title":"Int J Stroke"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S1474-4422(09)70150-4","article-title":"Motor recovery after stroke: a systematic review","volume":"8","author":"Langhorne","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"CD010820","DOI":"10.1002\/14651858.CD010820.pub2","article-title":"Interventions for improving upper limb function after stroke","volume":"2014","author":"Pollock","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1177\/0269215518765329","article-title":"Why do stroke survivors not receive recommended amounts of active therapy? 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