{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:24:28Z","timestamp":1790954668872,"version":"4.1.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Functional magnetic resonance imaging (fMRI) can be used to assess language and memory function as part of pre-surgical decision making in refractory epilepsy. Although language paradigms are well established, memory paradigms are not widely used in clinical practice due to a lack of evidence for robust and reliable methods. Here, we aim to investigate the clinical utility of the Home Town Walk (HTW) paradigm for personalized treatment decisions in medial temporal lobe epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 123 consecutive patients having HTW-fMRI as part of routine MRI scans over a 7.5\u2009year period were included in this retrospective study. Of these, 111 patients underwent repeated HTW-fMRI in two scanning sessions one to three days apart. fMRI analysis was performed at the time of the scans using clinically approved software and retrospectively validated using FSL. We assessed the test\u2013retest within subject reliability of activations within the posterior parahippocampal gyri (pPHG) at the individual subject level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>Activations within the pPHG region were observed for 101 patients (91%) in at least one of the fMRI sessions and for 88 patients (79%) in both fMRI sessions, with 82 patients showing overlapping unilateral or bilateral activations and 8 further patients showing overlapping activations in one of the hemispheres but not the other. Reproducibility was evaluated using metrics based on the concordance ratios for size (R<jats:sub>size<\/jats:sub>) and location (R<jats:sub>overlap<\/jats:sub>) within the pPHG region, as well as the lateralization index (LI) metric to reflect the asymmetry of hemispheric activations, which is of crucial relevance to inform surgery. Test\u2013retest reliability of visuospatial memory LIs, assessed by an intra-class correlation coefficient (ICC) yielded a value of 0.76, indicating excellent between session stability of memory lateralization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HTW-fMRI paradigm shows reproducible activations in the medial temporal lobes of individual epilepsy patients sufficient to consistently lateralize visuospatial memory function, demonstrating the clinical utility of HTW memory fMRI and its potential for application in the pre-surgical assessment of people with temporal lobe epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1419047","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:24:46Z","timestamp":1721712286000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Test-retest reliability of the \u201cHome Town Walk\u201d fMRI paradigm for memory activation and lateralization in the pre-surgical evaluation of patients with temporal lobe epilepsy"],"prefix":"10.3389","volume":"15","author":[{"given":"Rosa M.","family":"Sanchez Panchuelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Flintham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Wesolowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanika","family":"Samarasekera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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predicting the effects of temporal lobe resection","volume":"133","author":"Bonelli","year":"2010","journal-title":"Brain"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1528-1157.1995.tb00972.x","article-title":"Relationship of age at onset, chronologic age, and adequacy of preoperative performance to verbal memory change after anterior temporal lobectomy","volume":"36","author":"Hermann","year":"1995","journal-title":"Epilepsia"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.0013-9580.2005.10804.x","article-title":"Functional MRI predicts memory performance after right mesiotemporal epilepsy surgery","volume":"46","author":"Janszky","year":"2005","journal-title":"Epilepsia"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1523\/JNEUROSCI.3420-04.2005","article-title":"A dissociation of encoding and retrieval processes in the human Hippocampus","volume":"25","author":"Eldridge","year":"2005","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nrneurol.2011.3","article-title":"The neurobiology of cognitive disorders in temporal lobe epilepsy","volume":"7","author":"Bell","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1006\/brcg.1997.0930","article-title":"Differential involvement of left Temporolateral and Temporomesial structures in verbal declarative learning and memory: evidence from temporal lobe epilepsy","volume":"35","author":"Helmstaedter","year":"1997","journal-title":"Brain Cogn"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1037\/0894-4105.17.1.59","article-title":"Material-specific memory in temporal lobe epilepsy: effects of seizure laterality and language dominance","volume":"17","author":"Kim","year":"2003","journal-title":"Neuropsychol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1093\/brain\/awp182","article-title":"Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?","volume":"2009","author":"Helmstaedter","year":"2009","journal-title":"Brain"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1212\/WNL.57.10.1786","article-title":"Memory fMRI lateralizes temporal lobe epilepsy","volume":"57","author":"Jokeit","year":"2001","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1136\/jnnp.2007.115139","article-title":"Preoperative fMRI predicts memory decline following anterior temporal lobe resection","volume":"79","author":"Powell","year":"2008","journal-title":"J Neurol Neurosurg 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MRI","volume":"43","author":"Golby","year":"2002","journal-title":"Epilepsia"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1212\/WNL.0000000000001461","article-title":"Memory fMRI predicts verbal memory decline after anterior temporal lobe resection","volume":"84","author":"Sidhu","year":"2015","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1006\/nimg.2001.0908","article-title":"Delayed verbal memory retrieval: a functional MRI study in epileptic patients with structural lesions of the left medial temporal lobe","volume":"14","author":"Dupont","year":"2001","journal-title":"NeuroImage"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.neurad.2018.02.003","article-title":"Encoding and immediate retrieval tasks in patients with epilepsy: a functional MRI study of verbal and visual memory","volume":"45","author":"Saddiki","year":"2018","journal-title":"J Neuroradiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.3389\/fneur.2019.01384","article-title":"A functional MRI paradigm suitable for language and memory mapping in pediatric temporal lobe epilepsy","volume":"10","author":"Buck","year":"2020","journal-title":"Front Neurol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.3389\/fneur.2019.01354","article-title":"A guide to designing a memory fMRI paradigm for pre-surgical evaluation in temporal lobe epilepsy","volume":"10","author":"Buck","year":"2020","journal-title":"Front Neurol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fpsyt.2013.00163","article-title":"Test-retest reliability of fMRI brain activity during memory encoding","volume":"4","author":"Brandt","year":"2013","journal-title":"Front Psych"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"4033","DOI":"10.1002\/hbm.20827","article-title":"Test-retest reliability of fMRI verbal episodic memory paradigms in healthy older adults and in persons with mild cognitive impairment","volume":"30","author":"Cl\u00e9ment","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00234-006-0083-2","article-title":"The intersubject and intrasubject reproducibility of FMRI activation during three encoding tasks: implications for clinical applications","volume":"48","author":"Harrington","year":"2006","journal-title":"Neuroradiology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1002\/hbm.22726","article-title":"Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy","volume":"36","author":"Towgood","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"ref30","first-page":"2373","article-title":"Does mental activity change the oxidative metabolism of the brain?","volume":"7","author":"Roland","year":"1987","journal-title":"J Neurosci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"Jenkinson","year":"2012","journal-title":"FSL. Neuroimage."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/brain\/awv365","article-title":"Memory network plasticity after temporal lobe resection: a longitudinal functional imaging study","volume":"139","author":"Sidhu","year":"2016","journal-title":"Brain"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"NeuroImage"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"NeuroImage"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med Image Anal"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1006\/nimg.1995.1012","article-title":"A probabilistic atlas of the human brain: theory and rationale for its development. The international consortium for brain mapping (ICBM)","volume":"2","author":"Mazziotta","year":"1995","journal-title":"Neuroimage."},{"key":"ref37","first-page":"1317","article-title":"Test-retest analysis with functional MR of the activated area in the human visual cortex","volume":"18","author":"Rombouts","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/s1053-8119(03)00025-9","article-title":"Functional MR imaging in assessment of language dominance in epileptic patients","volume":"18","author":"Sabbah","year":"2003","journal-title":"NeuroImage"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1093\/brain\/122.11.2033","article-title":"Language dominance in neurologically normal and epilepsy subjects. A functional MRI study","volume":"122","author":"Springer","year":"1999","journal-title":"Brain"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1093\/brain\/awh281","article-title":"Functional MRI predicts post-surgical memory following temporal lobectomy","volume":"127","author":"Rabin","year":"2004","journal-title":"Brain"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1212\/01.WNL.0000049934.34209.2E","article-title":"Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI","volume":"60","author":"Fernandez","year":"2003","journal-title":"Neurology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1001\/archneurol.2011.94","article-title":"Test-retest reliability of memory task functional magnetic resonance imaging in alzheimer disease clinical trials","volume":"68","author":"Atri","year":"2011","journal-title":"Arch Neurol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1002\/hbm.21166","article-title":"Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults","volume":"32","author":"Putcha","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/(SICI)1097-0193(200003)9:3<156::AID-HBM4>3.0.CO;2-Q","article-title":"FMRI of visual encoding: reproducibility of activation","volume":"9","author":"Machielsen","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neuroimage.2005.06.005","article-title":"The reliability of fMRI activations in the medial temporal lobes in a verbal episodic memory task","volume":"28","author":"Wagner","year":"2005","journal-title":"NeuroImage"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1749-6632.2010.05446.x","article-title":"How reliable are the results from functional magnetic resonance imaging?","volume":"1191","author":"Bennett","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref47","first-page":"1","article-title":"Reliability of measurement","volume-title":"The design and analysis of clinical experiments","author":"Fleiss","year":"1986"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1126\/science.276.5310.264","article-title":"Separate neural bases of two fundamental memory processes in the human medial temporal lobe","volume":"276","author":"Gabrieli","year":"1997","journal-title":"Science"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"108461","DOI":"10.1016\/j.yebeh.2021.108461","article-title":"A clinically applicable functional MRI memory paradigm for use with pediatric patients","volume":"126","author":"Shurtleff","year":"2022","journal-title":"Epilepsy Behav"},{"key":"ref50","first-page":"498","article-title":"Memory lateralization with 2 functional MR imaging tasks in patients with lesions in the temporal lobe","volume":"27","author":"Avila","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1093\/brain\/awh293","article-title":"Preoperative verbal memory fMRI predicts post-operative memory decline after left temporal lobe resection","volume":"127","author":"Richardson","year":"2004","journal-title":"Brain"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1093\/brain\/awt105","article-title":"Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study","volume":"136","author":"Bonelli","year":"2013","journal-title":"Brain"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1419047\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:24:50Z","timestamp":1721712290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1419047\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":52,"alternative-id":["10.3389\/fneur.2024.1419047"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1419047","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"article-number":"1419047"}}