{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:43:37Z","timestamp":1779133417695,"version":"3.51.4"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low serum prealbumin levels have been identified as a predictor of infectious complication in critically ill patients. However, the association in patients with Community-acquired bacterial meningitis (CABM) remains unclear. The aim of this study is to investigate the relationship of prealbumin and the poor outcome of CABM through a retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 77 patients of CABM were enrolled. They were divided into good outcome group (GOS: 5) and a bad outcome group (GOS: 1\u20134). Serum prealbumin and other clinical records were measured within 24\u2009h after admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the included patients, 38(65.52%) had a bad outcome (the GOS score between 1 and 4). The mean age of the overall cohort was 45.3\u2009\u00b1\u200915.9\u2009years, and 58.6% of patients were male. The mean prealbumin level in the bad outcome group was 115.4\u2009\u00b1\u200949.4\u2009mmol\/L, while the mean level in the good outcome group was 199.1\u2009\u00b1\u200949.3\u2009mmol\/L (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Individuals with plasma prealbumin level\u2009\u2264180\u2009mmol\/L had a 3.32-fold higher risk of CABM than those with normal plasma prealbumin level [OR\u2009=\u20094.32 (1.02\u2009~\u200918.24), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced plasma prealbumin level is independently associated with the poor outcome of CABM. Plasma prealbumin level might help to identify patients at high risk of bad outcome.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1424069","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:35:40Z","timestamp":1726461340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between serum prealbumin level and prognosis of community-acquired bacterial meningitis in adults: a retrospective cohort study"],"prefix":"10.3389","volume":"15","author":[{"given":"Jing","family":"Shang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanping","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1128\/CMR.00070-09","article-title":"Epidemiology, 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