{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:51:39Z","timestamp":1787579499790,"version":"build-2736575974"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Increased fatty infiltration of the paraspinal muscles (PM) has been recognized as a sign of decreased muscle quality in patients with degenerative disc disease. However, whether fatty infiltration is a consequence of a neurogenic process due to spinal nerve root compression has not yet been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the correlation between fatty infiltration of the paraspinal muscles (PM) and neurogenic remodeling of motor unit action potentials (MUAPs) in patients with lumbar radiculopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>58 adult patients (32 women) with L5 radiculopathy caused by an L4-L5 herniated disc were examined. We compared the neurological status, EMG data of the PM at the L5 level on the affected side and the L4 level on the opposite side of the spine, and the severity of fatty infiltration of the PM assessed on axial T2-weighted magnetic resonance imaging (MRI) scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not find any correlation between the degree of fatty infiltration and neurogenic remodeling of MUAPs in the PM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lack of correlation between the degree of fatty infiltration and the presence of neurogenic remodeling of MUAPs in the PM suggests that fatty infiltration and neuropathic changes in muscles may be considered as separate processes requiring further research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1447432","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T05:10:42Z","timestamp":1734325842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Electromyography findings in L5 radiculopathy are not associated with fatty infiltration of paraspinal muscles: a retrospective observational study"],"prefix":"10.3389","volume":"15","author":[{"given":"Ekaterina","family":"Seliverstova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Sinkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Grin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref1","first-page":"1134","volume-title":"Clinically oriented anatomy","author":"Moore","year":"2014"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pmrj.2009.11.006","article-title":"The role of the lumbar multifidus in chronic low back pain: a review","volume":"2","author":"Freeman","year":"2010","journal-title":"PM R"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3390\/life14040499","article-title":"Pictorial essay on ultrasound and magnetic resonance imaging of Paraspinal muscles for myofascial pain syndrome","volume":"14","author":"Hung","year":"2024","journal-title":"Life (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12891-016-1376-1","article-title":"Correlation between lumbar dysfunction and fat infiltration in lumbar multifidus muscles in patients with low back pain","volume":"18","author":"Hildebrandt","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"E598","DOI":"10.1097\/BRS.0b013e318155837b","article-title":"Asymmetric atrophy of multifidus muscle in patients with unilateral lumbosacral radiculopathy","volume":"32","author":"Hyun","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.math.2011.05.007","article-title":"The relationship of transversus abdominis and lumbar multifidus clinical muscle tests in patients with chronic low back pain","volume":"16","author":"Hides","year":"2011","journal-title":"Man Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"E623","DOI":"10.1097\/BRS.0000000000000286","article-title":"Accuracy of magnetic resonance imaging signal intensity ratio measurements in the evaluation of multifidus muscle injury and atrophy relative to that of histological examinations","volume":"39","author":"Zhi-Jun","year":"2014","journal-title":"Spine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.17116\/neiro202286021109","article-title":"Electrodiagnostic evaluation in differential diagnosis and neurosurgical treatment of radiculopathies caused by spine disorders","volume":"86","author":"Seliverstova","year":"2022","journal-title":"Diagnostic value and methodology Zhurnal Voprosy Neirokhirurgii Imeni NN Burdenko"},{"key":"ref9","author":"Joseph","year":"2014"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/s0987-7053(02)00295-2","article-title":"Dorsal and lumbar paraspinal electromyographic study. Multi-MUP analysis and drawing up normal values in a reference population","volume":"32","author":"Tomasella","year":"2002","journal-title":"Neurophysiol Clin"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1080\/13685538.2021.1878130","article-title":"Age-related degeneration of lumbar muscle morphology in healthy younger versus older men","volume":"23","author":"Dallaway","year":"2020","journal-title":"Aging Male"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"52","DOI":"10.22540\/JFSF-07-052","article-title":"The relationship between radiological paraspinal lumbar measures and clinical measures of sarcopenia in older patients with chronic lower back pain","volume":"7","author":"Gibbons","year":"2022","journal-title":"J Frailty Sarcopenia Falls"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.21037\/qims-19-835","article-title":"Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females","volume":"10","author":"Peng","year":"2020","journal-title":"Quant Imaging Med Surg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1590\/s1808-185120212004250500","article-title":"Correlation between low back pain due to fatty degeneration and sex and age: study by MRI","volume":"20","author":"Felippe","year":"2021","journal-title":"Coluna\/Columna"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fendo.2016.00069","article-title":"Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity","volume":"7","author":"Hamrick","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"R561","DOI":"10.1152\/ajpregu.00198.2015","article-title":"Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity","volume":"310","author":"Rivas","year":"2016","journal-title":"Am J Phys Regul Integr Comp Phys"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1096\/fj.14-254011","article-title":"Glucocorticoids increase adipocytes in muscle by affecting IL-4 regulated FAP activity","volume":"28","author":"Dong","year":"2014","journal-title":"FASEB J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4248\/BR201302001","article-title":"Endogenous glucocorticoids and bone","volume":"1","author":"Zhou","year":"2013","journal-title":"Bone Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.brainres.2011.03.055","article-title":"Evolutionary conservation of glucocorticoids and corticotropin releasing hormone: behavioral and physiological adaptations","volume":"1392","author":"Schulkin","year":"2011","journal-title":"Brain Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1152\/japplphysiol.01020.2014","article-title":"Diminished satellite cells and elevated adipogenic gene expression in muscle as caused by ovariectomy are averted by low-magnitude mechanical signals","volume":"119","author":"Frechette","year":"2015","journal-title":"J Appl Physiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/1754-9485.12124","article-title":"Effect of androgen deprivation therapy on muscle attenuation in men with prostate cancer","volume":"58","author":"Chang","year":"2014","journal-title":"J Med Imaging Radiat Oncol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1447432\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T05:10:46Z","timestamp":1734325846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2024.1447432\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":21,"alternative-id":["10.3389\/fneur.2024.1447432"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2024.1447432","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"article-number":"1447432"}}