{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:26:15Z","timestamp":1779913575787,"version":"3.53.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Arterial dissection, a condition marked by the tearing of the carotid artery\u2019s inner layers, can result in varied clinical outcomes, including progression, stability, or spontaneous regression. Understanding these outcomes\u2019 underlying mechanisms is crucial for enhancing patient care, particularly with the increasing use of computer simulations in medical diagnostics and treatment planning. The aim of this study is to utilize computational analysis of blood flow and vascular wall to: (1) understand the pathophysiology of stroke-like episodes in patients with carotid artery dissection; and (2) assess the effectiveness of this method in predicting the evolution of carotid dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing contrast-enhanced magnetic resonance angiography (MRA), we segmented images of the patient\u2019s right internal carotid artery. These images were transformed into 3D solids for simulation in Ansys multifisic software, employing a two-way fluid structure interaction (FSI) analysis. Simulations were conducted across two wall conditions (atherosclerotic and normal) and three pressure states (hypotension, normotension, hypertension).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The simulations indicated a significant pressure discrepancy between the true and false lumens of the artery. This suggests that flap motion and functional occlusion under hypertensive conditions could be the cause of the clinical episodes. Thrombotic risk and potential for dissection extension were not found to be critical concerns. However, a non-negligible risk of vessel dilation was assessed, aligning with the patient\u2019s clinical follow-up data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights specific hemodynamic parameters that could elucidate carotid artery dissection\u2019s mechanisms, offering a potential predictive tool for assessing dissection progression and informing personalized patient care strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1455989","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:49:11Z","timestamp":1727671751000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the pathophysiology and evolution of internal carotid dissection: a fluid\u2013structure interaction simulation study"],"prefix":"10.3389","volume":"15","author":[{"given":"Adriano","family":"Bonura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Musotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Iaccarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Soeren","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda","family":"Calandrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fioravante","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Lazzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pilato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e26670","DOI":"10.5812\/archneurosci.26670","article-title":"Cervical artery dissection: a review of the epidemiology, pathophysiology, treatment, and outcome","volume":"2","author":"Blum","year":"2015","journal-title":"Arch Neurosci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"105561","DOI":"10.1016\/j.clineuro.2019.105561","article-title":"Non-traumatic cervical artery dissection and ischemic stroke: a narrative review of recent research","volume":"187","author":"Marciniec","year":"2019","journal-title":"Clin Neurol Neurosurg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"100058","DOI":"10.1016\/j.hsr.2022.100058","article-title":"Meta-analysis of cardiovascular risk profile of stroke secondary to spontaneous cervical artery dissection compared to ischemic stroke of other causes","volume":"5","author":"Abdelnour","year":"2022","journal-title":"Health Sci. 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