{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:34:16Z","timestamp":1784547256093,"version":"3.55.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:p>Intraventricular hemorrhage (IVH)4 is one of the most threatening neurological complications associated with preterm birth which can lead to long-term sequela such as cerebral palsy. Early recognition of IVH risk may prevent its occurrence and\/or reduce its severity. Using multivariate logistic regression analysis, risk factors significantly associated with IVH were identified and integrated into risk scales. A special aspect of this study was the inclusion of mathematically calculated cerebral blood flow (CBF) as an independent predictive variable in the risk score. Statistical analysis was based on clinical data from 254 preterm infants with gestational age between 23 and 30\u2009weeks of pregnancy. Several risk scores were developed for different clinical situations. Their efficacy was tested using ROC analysis, and validation of the best scores was performed on an independent cohort of 63 preterm infants with equivalent gestational age. The inclusion of routinely measured clinical parameters significantly improved IVH prediction compared to models that included only obstetric parameters and medical diagnoses. In addition, risk assessment with numerically calculated CBF demonstrated higher predictive power than risk assessments based on standard clinical parameters alone. The best performance in the validation cohort (with AUC\u2009=\u20090.85 and TPR\u2009=\u20090.94 for severe IVH, AUC\u2009=\u20090.79 and TPR\u2009=\u20090.75 for all IVH grades and FPR\u2009=\u20090.48 for cases without IVH) was demonstrated by the risk score based on the MAP, pH, CRP, CBF and leukocytes count.<\/jats:p>","DOI":"10.3389\/fneur.2024.1465440","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T04:44:46Z","timestamp":1729226686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of intraventricular hemorrhage risk in preterm infants using mathematically simulated cerebral blood flow"],"prefix":"10.3389","volume":"15","author":[{"given":"Irina","family":"Sidorenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Brodkorb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Felderhoff-M\u00fcser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rieger-Fackeldey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Feddahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Kovtanyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"L\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3238\/arztebl.2012.0527","article-title":"Risk-adjusted intraventricular hemorrhage rates in very premature infants: towards quality assurance between neonatal units","volume":"109","author":"Vogtmann","year":"2012","journal-title":"Dtsch Arztebl Int"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1515\/jpm-2020-0331","article-title":"Global incidence of intraventricular hemorrhage among extremely preterm infants: a systematic literature review","volume":"49","author":"Siffel","year":"2021","journal-title":"J Perinat Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1203\/PDR.0b013e3181c1b176","article-title":"Intraventricular hemorrhage in premature infants: mechanism of disease","volume":"67","author":"Ballabh","year":"2010","journal-title":"Pediatr Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/s41390-018-0141-6","article-title":"Neonatal cerebrovascular autoregulation","volume":"84","author":"Rhee","year":"2018","journal-title":"Pediatr Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41372-020-0650-0","article-title":"Comparing mortality risk models in VLBW and preterm infants: systematic review and meta-analysis","volume":"40","author":"McLeod","year":"2020","journal-title":"J Perinatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/s0140-6736(94)92158-x","article-title":"CRIB and SNAP: assessing the risk of death for preterm neonates","volume":"343","author":"Rautonen","year":"1994","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(03)13397-1","article-title":"CRIB II: an update of the clinical risk index for babies score","volume":"361","author":"Parry","year":"2003","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1542\/peds.91.3.617","article-title":"Score for neonatal acute physiology: a physiologic severity index for neonatal intensive care","volume":"91","author":"Richardson","year":"1993","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1067\/mpd.2001.109608","article-title":"SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores","volume":"138","author":"Richardson","year":"2001","journal-title":"J Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e1001","DOI":"10.1542\/peds.2008-3233","article-title":"SNAP-II and SNAPPE-II as predictors of death among infants born before the 28th week of gestation. 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