{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:20:31Z","timestamp":1787026831851,"version":"build-2736575974"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2022YJ-28"],"award-info":[{"award-number":["2022YJ-28"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21Y11923800"],"award-info":[{"award-number":["21Y11923800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of pressing needle therapy on depression, anxiety, and sleep in patients recovering from COVID-19, and to provide a more effective and convenient treatment for the sequelae of COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 136 patients recovering from COVID-19 were randomized into a treatment group (68 cases) and a control group (68 cases, with one case dropping out). The treatment group received pressing needle therapy, while the control group received sham pressing needle therapy, three times a week for 4\u202fweeks. The Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and Insomnia Severity Index (ISI) were used to evaluate patients\u2019 emotional states and sleep quality. These scales were assessed before, after, and at a 1-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to before treatment, the treatment group showed a significant decrease in PHQ-9 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, Cohen\u2019s d\u202f=\u202f1.26), GAD-7 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, Cohen\u2019s d\u202f=\u202f1.10), and ISI scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, Cohen\u2019s d\u202f=\u202f0.94) after treatment. Similarly, at the 1-month follow-up, significant decreases were observed in PHQ-9 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, Cohen\u2019s d\u202f=\u202f1.11), GAD-7 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, Cohen\u2019s d\u202f=\u202f0.88), and ISI scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, Cohen\u2019s d\u202f=\u202f0.94). In contrast, the control group demonstrated no statistically significant differences in PHQ-9, GAD-7, or ISI scores after treatment or at the 1-month follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). Between the two groups, statistically significant improvements (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05) were observed in PHQ-9 scores (Cohen\u2019s d\u202f=\u202f1.47), GAD-7 scores (Cohen\u2019s d\u202f=\u202f1.61), and ISI scores (Cohen\u2019s d\u202f=\u202f1.06) after treatment. At the 1-month follow-up, statistically significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05) between the two groups were also noted in PHQ-9 scores (Cohen\u2019s d\u202f=\u202f1.10), GAD-7 scores (Cohen\u2019s d\u202f=\u202f0.87), and ISI scores (Cohen\u2019s d\u202f=\u202f0.92).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pressing needle therapy significantly improves the mental health and sleep quality of patients recovering from COVID-19. It enhances their quality of life, promotes early recovery, and is simple and easy to administer, making it a treatment worthy of clinical application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.chictr.org.cn\/<\/jats:uri>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2024.1481557","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T01:49:26Z","timestamp":1734486566000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of pressing needle therapy on depression, anxiety, and sleep for patients in convalescence from COVID-19"],"prefix":"10.3389","volume":"15","author":[{"given":"Ruilong","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Cun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s11427-020-1661-4","article-title":"Clinical 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