{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T18:21:56Z","timestamp":1794075716083,"version":"4.8.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Montreal Cognitive assessment (MoCA) is a well-validated global cognitive screening instrument. Its validity in progressive supranuclear palsy (PSP) has not been assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the MoCA as an outcome measure in PSP clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cognitive data from 162 participants in the placebo arm of the Biogen PASSPORT study (NCT03068468) were analyzed using linear mixed-effects modeling (LMM) and repeated measures correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant decline in the MoCA score over time of \u22121.4 (95% CI \u22120.84 to \u22121.97) points over a 48-week period (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.0001). Small but significant changes (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01) were observed in all MoCA domains except abstraction. The MoCA correlated weakly with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) over time (<jats:italic>r<\/jats:italic><jats:sub>rm<\/jats:sub>\u202f=\u202f0.1, <jats:italic>p<\/jats:italic>\u202f=\u202f0.02) but exhibited a stronger correlation with the PSP Rating Scale (PSPRS) (<jats:italic>r<\/jats:italic><jats:sub>rm<\/jats:sub>\u202f=\u202f\u22120.25, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MoCA appears to have limited sensitivity in capturing cognitive decline in PSP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1501206","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T10:18:51Z","timestamp":1735035531000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Montreal cognitive assessment as a cognitive outcome measure in progressive supranuclear palsy"],"prefix":"10.3389","volume":"15","author":[{"given":"Vanessa","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Isroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Stephen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian L.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas 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