{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:02:59Z","timestamp":1790960579187,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The systemic immune\u2013inflammation index (SII) is a composite and easily available inflammation index, which can quantitatively reflect the degree of inflammation. This study aims to investigate the predictive value of admission SII for outcomes of large artery occlusion treated with mechanical thrombectomy (MT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted at Suining Central Hospital, Sichuan, China. Patients were stratified into quartiles based on their SII. The investigating outcomes included hemorrhagic transformation (HT), malignant brain edema (MBE), 90-day functional outcome, and mortality. The adverse function was defined as the modified Rankin Scale (mRS) score\u202f&amp;gt;\u202f2 at the 90-day follow-up. Multivariate analysis was performed to explore the relationships between SII and outcomes. In addition, cases (distinguished from the aforementioned patients) treated with MT\u202f+\u202fmild hypothermia (MH) were also included to elucidate the relationships between SII\/MH and outcomes in a new cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 323 patients treated with MT were included. The observed HT, MBE, adverse function, and mortality rates were 31.9, 25.7, 59.4, and 27.9%, respectively. Multivariate analysis demonstrated that heightened SII was significantly related to HT (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.035\u20131.086, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), MBE (OR: 1.074, 95% CI: 1.045\u20131.103, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), adverse function (OR: 1.061, 95% CI: 1.031\u20131.092, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), and mortality (OR: 1.044, 95% CI: 1.018\u20131.070, <jats:italic>p<\/jats:italic>\u202f=\u202f0.001), after adjusting sex, age, Glasgow Coma Scale (GCS) score at admission, initial National Institutes of Health Stroke Scale (NIHSS) score, baseline Alberta Stroke Program Early Computed Tomography Score (ASPECTS), present HMCAS, occluded vessel region, collateral score and successful revascularization. HT and MBE may partially account for patients with elevated SII\u2019s adverse function and mortality. In addition, with the criterion of baseline ASPECTS \u2264 7, a total of 42 patients treated with MT\u202f+\u202fMH were enrolled to build up a new cohort combined with 72 patients treated with mere MT. The risk role of SII and protect effect of MH were identified for HT (SII\u2014OR: 1.037, 95% CI: 1.001\u20131.074; MH\u2014OR: 0.361, 95% CI: 0.136\u20130.957), MBE (SII\u2014OR: 1.063, 95% CI: 1.019\u20131.109; MH\u2014OR: 0.231, 95% CI: 0.081\u20130.653), and mortality (SII\u2014OR: 1.048, 95% CI: 1.011\u20131.087; MH\u2014OR: 0.343, 95% CI: 0.118\u20130.994).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated SII was related to HT, MBE, 90-day adverse function, and mortality after MT. The MH may improve prognosis under high inflammation status.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2024.1516577","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T05:24:55Z","timestamp":1738128295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive value of the systemic immune\u2013inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy\u2014a single-center 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