{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T09:59:25Z","timestamp":1772877565186,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the efficacy and safety of successful interventional recanalization in patients with low NIHSS score acute cerebral infarction due to anterior circulation large vessel occlusion and influencing factors of futile recanalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on the clinical data of patients with acute cerebral infarction due to anterior circulation large vessel occlusion treated in our hospital from January 2019 to December 2023. Statistical methods such as chi square test, t-test and non parametric test for statistical analysis were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 445 patients were included in the study, including 32 in the low NIHSS score group and 413 in the non low NIHSS score group. There were statistical differences in NIHSS score at onset, preoperative ASPECT score, collateral circulation score, pathogenesis, effective recanalization rate, futile recanalization rate and 3-month postoperative mRS score between the two groups. There was no statistical difference in the incidence of complications such as symptomatic cerebral hemorrhage between the two groups. There were statistically significant differences in preoperative ASPECT score and collateral circulation score in terms of factors affecting futile recanalization in patients with low NIHSS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with acute cerebral infarction with anterior circulation large vessel occlusion and low NIHSS score had good therapeutic effect after successful interventional recanalization, and the safety was comparable to that of patients with non low NIHSS score. The factors that affecting futile recanalization in patients with low NIHSS score included preoperative ASPECT score and collateral circulation score.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1473306","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T05:24:38Z","timestamp":1741325078000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect and safety of interventional recanalization in acute cerebral infarction with low NIHSS score due to anterior circulation large vessel occlusion and exploration of factors associated with futile recanalization"],"prefix":"10.3389","volume":"16","author":[{"given":"Wensheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangchun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1136\/neurintsurg-2019-015383","article-title":"Mortality reduction after thrombectomy for acute intracranial large vessel occlusion: meta-analysis of randomized trials","volume":"12","author":"Yaeger","year":"2020","journal-title":"J Neurointerv Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3416","DOI":"10.1161\/STROKEAHA.115.011397","article-title":"Endovascular therapy is effective and safe for patients with severe ischemic stroke: pooled analysis of interventional Management of Stroke III and multicenter randomized clinical trial of endovascular therapy for acute ischemic stroke in the Netherlands data","volume":"46","author":"Broderick","year":"2015","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1136\/neurintsurg-2018-013911","article-title":"AHA\/ASA 2018 AIS guidelines: impact and opportunity for endovascular stroke care","volume":"10","author":"Leslie-Mazwi","year":"2018","journal-title":"J Neurointerv Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"S126","DOI":"10.1212\/WNL.0000000000012801","article-title":"Indications for mechanical Thrombectomy for acute ischemic stroke: current guidelines and beyond","volume":"97","author":"Jadhav","year":"2021","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"107592","DOI":"10.1016\/j.clineuro.2023.107592","article-title":"Outcomes after endovascular mechanical thrombectomy for low compared to high National Institutes of Health stroke scale (NIHSS): a multicenter study","volume":"225","author":"Abecassis","year":"2023","journal-title":"Clin Neurol Neurosurg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"MR CLEAN Investigators. A randomized trial of intraarterial treatment for acute ischemic stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"ESCAPE trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","article-title":"EXTEND-IA Investigators. Endovascular therapy for ischemic stroke with perfusion-imaging selection","volume":"372","author":"Campbell","year":"2015","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","article-title":"Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke","volume":"372","author":"Saver","year":"2015","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1056\/NEJMoa1503780","article-title":"REVASCAT trial Investigators. Thrombectomy within 8 hours after symptom onset in ischemic stroke","volume":"372","author":"Jovin","year":"2015","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1136\/neurintsurg-2016-012633","article-title":"Too good to intervene? Thrombectomy for large vessel occlusion strokes with minimal symptoms: an intention-to-treat analysis","volume":"9","author":"Haussen","year":"2016","journal-title":"J Neurointerv Surg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"105091","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105091","article-title":"Mechanical thrombectomy in patients with proximal occlusions and low NIHSS: results from a large prospective registry","volume":"29","author":"Renieri","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1161\/STROKEAHA.123.043937","article-title":"Medical management versus endovascular treatment for large-vessel occlusion anterior circulation stroke with low NIHSS","volume":"54","author":"Safouris","year":"2023","journal-title":"Stroke"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1136\/svn-2016-000052","article-title":"Mechanical thrombectomy in patients with M1 occlusion and NIHSS score \u22645: a single-Centre experience","volume":"1","author":"Bhogal","year":"2016","journal-title":"Stroke Vasc Neurol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1177\/1591019918760747","article-title":"Mechanical thrombectomy in MCA-mainstem occlusion in patients with low NIHSS scores","volume":"24","author":"Kaschner","year":"2018","journal-title":"Interv Neuroradiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/neurintsurg-2013-010720","article-title":"Outcomes in patients with acute ischemic stroke from proximal intracranial vessel occlusion and NIHSS score below 8","volume":"6","author":"Mokin","year":"2014","journal-title":"J Neurointerv Surg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/STROKEAHA.118.021106","article-title":"Mechanical Thrombectomy in patients with milder strokes and large vessel occlusions","volume":"49","author":"Nagel","year":"2018","journal-title":"Stroke"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"106282","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106282","article-title":"Mechanical Thrombectomy in patients presenting with NIHSS score <6: a safety and efficacy analysis","volume":"31","author":"Abbas","year":"2022","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1093\/neuros\/nyz354","article-title":"The safety and feasibility of mechanical Thrombectomy for mild acute ischemic stroke with large vessel occlusion","volume":"86","author":"Toth","year":"2020","journal-title":"Neurosurgery"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1473306\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T05:24:40Z","timestamp":1741325080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1473306\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":21,"alternative-id":["10.3389\/fneur.2025.1473306"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1473306","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"article-number":"1473306"}}