{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:25:59Z","timestamp":1790443559612,"version":"4.1.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Patients with subthreshold depression (sD) carry a significant risk of developing major depressive disorder. However, few studies focus on the influence of Internet-based Cognitive Behavioral Therapy (ICBT) on brain network, particularly among Chinese undergraduates. This study aims to conduct resting-state functional MRI (rs-fMRI) to explore the effects of ICBT on neurofunctional network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This short-term longitudinal study enrolled 30 sD patients and 24 healthy matched participants. We gathered the clinical measurements outcomes from sD patients. Baseline and post-intervention MRI scans were performed for the sD patients, additionally, a matched healthy controls group underwent baseline MRI scans, functional network matrix was established from the temporal rs-MRI series. Nodal efficiency (<jats:italic>E<\/jats:italic>nod) was quantified by calculating the area under the curve (AUC) of network metrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with sD exhibited reduced clinical measurement scores after ICBT intervention. Moreover, after ICBT intervention, functional network analysis revealed an increased <jats:italic>E<\/jats:italic>nod in the orbital part of the left inferior frontal gyrus, and decreased <jats:italic>E<\/jats:italic>nod in the left paracentral lobule and right precentral gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed alterations in brain network in patients with sD after ICBT intervention. These findings shed light on the neurofunctional mechanisms underlying the effects of ICBT in sD patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1474339","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:21:11Z","timestamp":1744723271000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy"],"prefix":"10.3389","volume":"16","author":[{"given":"Wenquan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiLing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1192\/bjp.bp.113.138784","article-title":"Psychotherapy 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