{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:41:29Z","timestamp":1792528889381,"version":"4.5.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Insomnia is a widespread sleep disorder that significantly affects the quality of life and contributes to immune dysfunction, which in turn leads to chronic diseases. Despite extensive research on sleep disturbances and immune modulation, the relationship between insomnia and immune responses remains underexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective of this study was to conduct a bibliometric analysis to explore the interaction between immune cells and insomnia, identifying key immune responses involved and their potential roles in the development of insomnia and associated comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A bibliometric analysis was conducted using data from the Web of Science Core Collection (WoSCC), focusing on research articles published between 2000 and 2023. The analysis aimed to identify trends, key research areas, and the role of immune system cells (T cells, B cells, NK cells, etc.) in insomnia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis revealed that various immune cells, including T cells, B cells, NK cells, neutrophils, and monocytes, play crucial roles in insomnia pathogenesis. These immune cells contribute to immune modulation and inflammatory responses, which are linked to sleep disturbances. The study also identified that insomnia is closely associated with comorbidities such as cardiovascular diseases, obesity, depression, and cancer, all of which involve immune dysfunction. The regulation of the immune system was found to be a key factor in improving sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides valuable insights into the complex interaction between the immune system and insomnia. The findings underscore the importance of immune regulation in the treatment of insomnia, suggesting that future research should focus on integrating immune modulation into therapeutic strategies for insomnia. Further studies are needed to explore targeted therapies for immune-related insomnia and its comorbidities, emphasizing interdisciplinary research in this area.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1486548","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:18:58Z","timestamp":1742966338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Interference between immune cells and insomnia: a bibliometric analysis from 2000 to 2023"],"prefix":"10.3389","volume":"16","author":[{"given":"Nana","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.sleep.2023.07.013","article-title":"Insomnia symptoms in adulthood. Prevalence and incidence over 25 years","volume":"109","author":"Klimt","year":"2023","journal-title":"Sleep Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jshs.2022.02.002","article-title":"Prospective associations between joint categories of physical activity and insomnia symptoms with onset of poor mental health in a population-based cohort","volume":"12","author":"Duncan","year":"2023","journal-title":"J Sport Health Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"691","DOI":"10.31128\/AJGP-01-23-6678","article-title":"General practitioner assessment and management of insomnia in adults","volume":"52","author":"Sweetman","year":"2023","journal-title":"Aust J Gen Pract"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3949\/ccjm.91a.23061","article-title":"Reducing the risks when using benzodiazepines to treat insomnia: a public health approach","volume":"91","author":"Modesto-Lowe","year":"2024","journal-title":"Cleve Clin J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"103074","DOI":"10.1016\/j.ctim.2024.103074","article-title":"Acupuncture-related therapy for cancer-related insomnia: An overview of systematic reviews and meta-analysis","volume":"85","author":"Guo","year":"2024","journal-title":"Complement Ther Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1177\/02698811241268900","article-title":"Insomnia and the effect of zolpidem-extended-release on the sleep items of the Hamilton rating scale for depression in outpatients with depression, insomnia, and suicidal ideation: relationship to patient age","volume":"38","author":"Mccall","year":"2024","journal-title":"J Psychopharmacol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12884-024-06540-w","article-title":"Associations between anxiety, sleep, and blood pressure parameters in pregnancy: a prospective pilot cohort study","volume":"24","author":"Miller","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.sleep.2024.05.029","article-title":"The effect of cognitive behavioral therapy for insomnia on sleep and glycemic outcomes in people with type 2 diabetes: a randomized controlled trial","volume":"120","author":"Groeneveld","year":"2024","journal-title":"Sleep Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1097\/MS9.0000000000000784","article-title":"Exploring the relationship between insomnia and depression: a cross-sectional prospective study","volume":"85","author":"Mohammed","year":"2023","journal-title":"Ann Med Surg"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/s42003-021-02825-4","article-title":"Role of sleep deprivation in immune-related disease risk and outcomes","volume":"4","author":"Garbarino","year":"2021","journal-title":"Commun Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"901","DOI":"10.7150\/ijbs.11907","article-title":"Sleep deprivation induces changes in immunity in Trichinella spiralis-infected rats","volume":"11","author":"Ibarra-Coronado","year":"2015","journal-title":"Int J Biol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1517\/14712598.2014.920813","article-title":"Emerging trends and new developments in regenerative medicine: a scientometric update (2000 - 2014)","volume":"14","author":"Chen","year":"2014","journal-title":"Expert Opin Biol Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1474-4422(12)70310-1","article-title":"Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study","volume":"12","author":"Titulaer","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S1474-4422(10)70253-2","article-title":"Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis","volume":"10","author":"Dalmau","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S1474-4422(15)00401-9","article-title":"A clinical approach to diagnosis of autoimmune encephalitis","volume":"15","author":"Graus","year":"2016","journal-title":"Lancet Neurol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1381765","DOI":"10.3389\/fimmu.2024.1381765","article-title":"Elucidating sleep disorders: a comprehensive bioinformatics analysis of functional gene sets and hub genes","volume":"15","author":"Lin","year":"2024","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e15181","DOI":"10.1111\/1756-185X.15181","article-title":"Novel electrical therapy to improve sleep disturbance in patients with autoimmune rheumatic diseases","volume":"27","author":"Zhao","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13020-024-00939-5","article-title":"The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system","volume":"19","author":"Rong","year":"2024","journal-title":"Chin Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"16955","DOI":"10.1038\/s41598-024-68074-7","article-title":"Poor sleep quality and its associated factors among HIV\/ADIS patients living in sub-Saharan African countries: a systematic review and meta-analysis","volume":"14","author":"Melese","year":"2024","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1038\/s41598-020-59541-y","article-title":"Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice","volume":"10","author":"Inokawa","year":"2020","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"149326","DOI":"10.1016\/j.bbrc.2023.149326","article-title":"Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression","volume":"691","author":"Xing","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"zsz222","DOI":"10.1093\/sleep\/zsz222","article-title":"Short-term sleep deprivation in mice induces B cell migration to the brain compartment","volume":"43","author":"Korin","year":"2020","journal-title":"Sleep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s00405-018-5219-6","article-title":"Differential expression of immune markers in the patients with obstructive sleep apnea\/hypopnea syndrome","volume":"276","author":"Xie","year":"2019","journal-title":"Eur Arch Otorrinolaringol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/jcp.25231","article-title":"Effects of sleep deprivation on mice bone marrow and spleen B Lymphopoiesis","volume":"231","author":"Lungato","year":"2016","journal-title":"J Cell Physiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/978-981-19-7376-5_12","article-title":"Sleep immune cross talk and insomnia","volume":"1411","author":"Akkaoui","year":"2023","journal-title":"Adv Exp Med Biol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"7943","DOI":"10.3390\/curroncol29100628","article-title":"Sleep disturbance affects immune factors in clinical liver Cancer patients","volume":"29","author":"Wang","year":"2022","journal-title":"Curr Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"15347354241242120","DOI":"10.1177\/15347354241242120","article-title":"Effects of Reishimmune-S, a fungal immunomodulatory peptide supplement, on the quality of life and circulating natural killer cell profiles of patients with early breast Cancer receiving adjuvant endocrine therapy","volume":"23","author":"Su","year":"2024","journal-title":"Integr Cancer Ther"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"843426","DOI":"10.3389\/fcvm.2022.843426","article-title":"Identification of potential diagnostic biomarkers from circulating cells during the course of sleep deprivation-related myocardial infarction based on bioinformatics analyses","volume":"9","author":"Chen","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"5500","DOI":"10.1016\/j.cell.2023.10.025","article-title":"Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals","volume":"186","author":"Sang","year":"2023","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e35470","DOI":"10.1016\/j.heliyon.2024.e35470","article-title":"Altered neutrophil extracellular traps formation among medical residents with sleep deprivation","volume":"10","author":"Elhasid","year":"2024","journal-title":"Heliyon"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"17379","DOI":"10.1038\/s41598-024-68498-1","article-title":"The effect of sleep and its restriction on selected inflammatory parameters","volume":"14","author":"Sochal","year":"2024","journal-title":"Sci Rep"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.bbi.2024.07.023","article-title":"Effects of low-dose acetylsalicylic acid on the inflammatory response to experimental sleep restriction in healthy humans","volume":"121","author":"Engert","year":"2024","journal-title":"Brain Behav Immun"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s11481-023-10078-7","article-title":"Natural Immunosuppressants as a treatment for chronic insomnia targeting the inflammatory response induced by NLRP3\/caspase-1\/IL-1\u03b2 Axis activation: a scooping review","volume":"18","author":"Aghelan","year":"2023","journal-title":"J Neuroimmune Pharmacol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e12525","DOI":"10.1111\/jpi.12525","article-title":"Melatonin and inflammation-story of a double-edged blade","volume":"65","author":"Hardeland","year":"2018","journal-title":"J Pineal Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1477903","DOI":"10.3389\/fnmol.2024.1477903","article-title":"Exploring shared biomarkers and shared pathways in insomnia and atherosclerosis using integrated bioinformatics analysis","volume":"17","author":"Yang","year":"2024","journal-title":"Front Mol Neurosci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41586-019-0948-2","article-title":"Sleep modulates haematopoiesis and protects against atherosclerosis","volume":"566","author":"McAlpine","year":"2019","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1001\/archinte.166.16.1756","article-title":"Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation","volume":"166","author":"Irwin","year":"2006","journal-title":"Arch Intern Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1088135","DOI":"10.3389\/fendo.2023.1088135","article-title":"Poor sleep pattern is associated with metabolic disorder during transition from adolescence to adulthood","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01103-8","article-title":"Adipokines: masterminds of metabolic inflammation","author":"Tilg","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","article-title":"Sleep disturbance, sleep duration, and inflammation: a systematic review and Meta-analysis of cohort studies and experimental sleep deprivation","volume":"80","author":"Irwin","year":"2016","journal-title":"Biol Psychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jad.2024.03.023","article-title":"Reduced coupling between global signal and cerebrospinal fluid inflow in patients with depressive disorder: a resting state functional MRI study","volume":"354","author":"Zhang","year":"2024","journal-title":"J Affect Disord"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bbi.2022.12.002","article-title":"Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: analysis of data from the FACE-BD cohort","volume":"108","author":"Lengvenyte","year":"2023","journal-title":"Brain Behav Immun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.3390\/cells13151246","article-title":"The triad of sleep, immunity, and Cancer: a mediating perspective","volume":"13","author":"Lanza","year":"2024","journal-title":"Cells"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1042663","DOI":"10.3389\/fcimb.2022.1042663","article-title":"A systematic assessment of stress insomnia as the high-risk factor for cervical cancer and interplay of cervicovaginal microbiome","volume":"12","author":"Rai","year":"2022","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Frontiers in Neurology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1486548\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:19:01Z","timestamp":1742966341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2025.1486548\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":44,"alternative-id":["10.3389\/fneur.2025.1486548"],"URL":"https:\/\/doi.org\/10.3389\/fneur.2025.1486548","relation":{},"ISSN":["1664-2295"],"issn-type":[{"value":"1664-2295","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"article-number":"1486548"}}