{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T23:44:36Z","timestamp":1771890276614,"version":"3.50.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to explore the clinical features and predictive factors for visual prognosis of neurosyphilis-associated optic atrophy (NSAOA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study included 17 patients (33 eyes) with NSAOA who received standard anti-ocular syphilis treatment. LogMAR (logarithm of the minimum angle of resolution) best-corrected visual acuity (BCVA), visual field, and optical coherence tomography, were recorded at baseline, short-term (within one month after treatment), and long-term (&amp;gt; 6\u202fmonths) follow-up. Patients with at least one eye with LogMAR BCVA of \u22651.3 at the last follow-up visit were categorized as the blind group. A change \u22650.2 on the LogMAR BCVA indicated improvement or deterioration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 58.5\u202fyears, and 15 patients were males. The mean time between the onset and treatment was 10.1\u202fmonths. Thirteen patients had Argyll-Robertson pupils. The unblinded group had younger age, shorter disease duration, better baseline visual acuity, higher baseline cerebrospinal fluid (CSF) venereal disease research laboratory (VDRL) titer and CSF total protein counts than the blind group. BCVA of most eyes improved after treatment but experienced deterioration during the follow-up. The deteriorated group of eyes had lower baseline visual field parameters, thinner inferior peripapillary retinal nerve fiber layer (RNFL) thickness. The long-term LogMAR BCVA moderately negatively correlated with CSF VDRL titers before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnosis is often delayed in NSAOA, and the overall visual prognosis is poor. Older age, longer symptom duration, worse baseline vision, thinner RNFL thickness, and lower CSF VDRL titer and total protein counts are significantly associated with worse long-term visual prognosis. The correlation between syphilis serologic test and visual prognosis is poor. It is recommended to reexamine CSF in the follow-up.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fneur.2025.1503956","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:11:04Z","timestamp":1740373864000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive factors for visual prognosis in neurosyphilis presenting with optic atrophy: a Chinese case series study"],"prefix":"10.3389","volume":"16","author":[{"given":"Mingjie","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1056\/NEJMc1914502","article-title":"Neurosyphilis","volume":"381","author":"Ropper","year":"2019","journal-title":"Reply N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/olq.0000000000000687","article-title":"Reported cases of Neurosyphilis among early syphilis cases-United States, 2009 to 2015","volume":"45","author":"de Voux","year":"2018","journal-title":"Sex Transm Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3969\/j.issn.1674-8115.2021.05.015","article-title":"Temporal and spatial distribution characteristics analysis of syphilis incidence in China","volume":"41","author":"Tian","year":"2021","journal-title":"J Shanghai Jiao Tong Univ"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1128\/jcm.02522-13","article-title":"Comparison of the cerebrospinal fluid (CSF) toluidine red unheated serum test and the CSF rapid plasma reagin test with the CSF venereal disease research laboratory test for diagnosis of neurosyphilis among HIV-negative syphilis patients in China","volume":"52","author":"Zhu","year":"2014","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.15585\/mmwr.mm6543a2","article-title":"Ocular syphilis - 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